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GENE：CLK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLK4
FullNmae CDC like kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13659
EnsembleID ENSG00000113240
Uniprot Q9HAZ1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLK4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CLK4 GO:0004674,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0016310,GO:0018108,GO:0043484,GO:0043484,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLK4 hsa:57396 path:hsa05134 Legionellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 CLK4 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 CLK4 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR CLK4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CLK4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CLK4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CLK4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CLK4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CLK4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 CLK4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA CLK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CLK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CLK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CLK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 CLK4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 CLK4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001F14FE CLK4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 CLK4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D CLK4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A CLK4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CLK4 ABL1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIM2 CLK4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRTAP10-8 CLK4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-7 CLK4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KPNA1 CLK4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CLK4 UBL5 12705895 12824502 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CLK4 CLASRP 12169693 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CLK4 JMJD6 25348397 N/A physical interaction ComPPI
CLK4 RNF181 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CLK4 SRRM2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CLK4 AHCYL2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CLK4 RASA4 25348397 N/A physical interaction ComPPI
CLK4 SUB1 25348397 N/A physical interaction ComPPI
CLK4 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CLK4 KRTAP10-9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CLK4 KRTAP10-3 25348397 N/A physical interaction ComPPI
CLK4 MOV10 25348397 N/A physical interaction ComPPI
CLK4 RGMA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLK4 ZC3H18 25348397 N/A physical interaction ComPPI
CLK4 LNX1 25348397 N/A physical interaction ComPPI
CLK4 KRTAP10-6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLK4 SRRM4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLK4 HSPB2 12705895 14525934 N/A two hybrid HPRD
CLK4 CLK4 12824502 14525934 N/A two hybrid HPRD
CLK4 ABL1 18794806 27898060 inhibition N/A OmniPath

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