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GENE：CLN5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLN5
FullNmae CLN5 intracellular trafficking protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2076
EnsembleID ENSG00000102805
Uniprot O75503

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLN5 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CLN5 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CLN5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLN5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CLN5 GO:0005515,GO:0005537,GO:0005764,GO:0005765,GO:0005765,GO:0005775,GO:0005783,GO:0005794,GO:0005829,GO:0006465,GO:0007040,GO:0007042,GO:0007420,GO:0007601,GO:0016020,GO:0016020,GO:0016798,GO:0022008,GO:0030163,GO:0042147,GO:0042551,GO:0048471,GO:0070062,GO:0070085,GO:1904426

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLN5 hsa:1203 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 CLN5 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CLN5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CLN5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HNF4A CLN5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN CLN5 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB CLN5 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYBL1 CLN5 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC CLN5 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A CLN5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RPN1 CLN5 25348397 N/A physical interaction ComPPI
MMP3 CLN5 25348397 N/A physical interaction ComPPI
SLC25A6 CLN5 25348397 N/A physical interaction ComPPI
CANX CLN5 25348397 N/A physical interaction ComPPI
CALR CLN5 25348397 N/A physical interaction ComPPI
XPO1 CLN5 25348397 N/A physical interaction ComPPI
CYP1A1 CLN5 25348397 N/A physical interaction ComPPI
ATP2A2 CLN5 25348397 N/A physical interaction ComPPI
SPNS1 CLN5 25348397 N/A physical interaction ComPPI
OS9 CLN5 25348397 N/A physical interaction ComPPI
ARF4 CLN5 25348397 N/A physical interaction ComPPI
CLGN CLN5 25348397 N/A physical interaction ComPPI
GANAB CLN5 25348397 N/A physical interaction ComPPI
TARDBP CLN5 25348397 N/A physical interaction ComPPI
SEC61A1 CLN5 25348397 N/A physical interaction ComPPI
KRT8 CLN5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RCN2 CLN5 25348397 N/A physical interaction ComPPI
SLC25A5 CLN5 25348397 N/A physical interaction ComPPI
SLC25A4 CLN5 25348397 N/A physical interaction ComPPI
PHGDH CLN5 25348397 N/A physical interaction ComPPI
SLC25A11 CLN5 25348397 N/A physical interaction ComPPI
FBXO6 CLN5 25348397 N/A physical interaction ComPPI
ATP1A3 CLN5 25348397 N/A physical interaction ComPPI
CALU CLN5 25348397 N/A physical interaction ComPPI
PTPRK CLN5 25348397 N/A physical interaction ComPPI
CLN5 SEL1L 25348397 N/A physical interaction ComPPI
CLN5 SLC25A13 25348397 N/A physical interaction ComPPI
CLN5 SLC25A22 25348397 N/A physical interaction ComPPI
CLN5 CDIPT 25348397 N/A physical interaction ComPPI
CLN5 HMGCS1 25348397 N/A physical interaction ComPPI
CLN5 FBXO27 25348397 N/A physical interaction ComPPI

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