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GENE：IBTK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IBTK
FullNmae inhibitor of Bruton tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17853
EnsembleID ENSG00000005700
Uniprot Q9P2D0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IBTK autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IBTK GO:0001933,GO:0001933,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0016020,GO:0019901,GO:0019901,GO:0030292,GO:0030292,GO:0051209

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 IBTK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IBTK 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IBTK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IBTK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IBTK 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 IBTK 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IBTK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 IBTK 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002367FA IBTK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000040FA88 IBTK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 IBTK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B IBTK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 IBTK 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 IBTK 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCB IBTK 22135298 phosphorylation N/A PhosphoSite
IBTK BTK 25361965 interaction type N/A PTMCode2
BTK IBTK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DDX21 IBTK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPP25L IBTK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POP7 IBTK 25348397 N/A physical interaction ComPPI
CD2BP2 IBTK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DPPA4 IBTK 25348397 N/A physical interaction ComPPI
BTK IBTK 11577348 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
RPL10 IBTK 25348397 N/A physical interaction ComPPI
PRKCA IBTK 25348397 N/A physical interaction ComPPI
CD81 IBTK 25348397 N/A physical interaction ComPPI
PRKCD IBTK 25348397 N/A physical interaction ComPPI
PRKD1 IBTK 25348397 N/A physical interaction ComPPI
PRKCE IBTK 25348397 N/A physical interaction ComPPI
ITK IBTK 25348397 N/A physical interaction ComPPI
RBX1 IBTK 25348397 N/A physical interaction ComPPI
CUL3 IBTK 25348397 N/A physical interaction ComPPI
UBC IBTK 25348397 N/A physical interaction ComPPI
PPP1CA IBTK 22321011 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMTOR3 IBTK 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKCB IBTK 25348397 N/A physical interaction ComPPI
RGS2 IBTK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP135 IBTK 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRKCG IBTK 25348397 N/A physical interaction ComPPI
COPS2 IBTK 25348397 N/A physical interaction ComPPI
PDCD4 IBTK 25348397 N/A physical interaction ComPPI
RPLP0 IBTK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPLP1 IBTK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ODF2 IBTK 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CENPJ IBTK 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COPS3 IBTK 25348397 N/A physical interaction ComPPI
COPS4 IBTK 25348397 N/A physical interaction ComPPI
BCOR IBTK 25348397 N/A physical interaction ComPPI
IBTK AKT1 25348397 N/A physical interaction ComPPI
IBTK PLCG1 25348397 N/A physical interaction ComPPI
IBTK IGSF8 25348397 N/A physical interaction ComPPI
IBTK CAND1 25348397 N/A physical interaction ComPPI
IBTK UBA1 25348397 N/A physical interaction ComPPI
IBTK PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK B9D2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK CEP120 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK DYNLT1 25348397 N/A physical interaction ComPPI
IBTK POC1A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK RPGRIP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
IBTK EIF4A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RFC1 25348397 N/A physical interaction ComPPI
IBTK RFC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RFC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RPL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RPLP0P6 25348397 N/A physical interaction ComPPI
IBTK RPS3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RPS8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RPS9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK RPS27 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK SRP72 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK USP10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK ESPL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK DHX30 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK TTK 25348397 N/A physical interaction ComPPI
IBTK NOP56 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK CNOT1 25348397 N/A physical interaction ComPPI
IBTK FTSJ1 25348397 N/A physical interaction ComPPI
IBTK DOT1L 25348397 N/A physical interaction ComPPI
IBTK WDR74 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK NAT10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK TSR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK LACTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IBTK MSL1 25348397 N/A physical interaction ComPPI
IBTK PCGF1 25348397 N/A physical interaction ComPPI
IBTK NANOGP8 25348397 N/A physical interaction ComPPI
IBTK NANOG 25348397 N/A physical interaction ComPPI
IBTK POU5F1 25348397 N/A physical interaction ComPPI
IBTK TRIM25 25348397 N/A physical interaction ComPPI
IBTK SNRPN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IBTK EIF4A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IBTK TCTE1 24234451 25348397 26638075 association proximity-dependent biotin identification ComPPI,IntAct
PRKCB IBTK 21482705 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B3C5F IBTK 27087310 direct interaction,inhibition N/A NPInter

Visualization










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