GENE：OGG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | OGG1 |
| FullNmae | 8-oxoguanine DNA glycosylase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8125 |
| EnsembleID | ENSG00000114026 |
| Uniprot | O15527 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| OGG1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| OGG1 | parthanatos | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| OGG1 | GO:0003684,GO:0004519,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005759,GO:0005829,GO:0006284,GO:0006285,GO:0006289,GO:0006355,GO:0006974,GO:0006979,GO:0008017,GO:0008534,GO:0009314,GO:0009410,GO:0009416,GO:0016363,GO:0016607,GO:0032355,GO:0032357,GO:0032991,GO:0034039,GO:0034039,GO:0043066,GO:0045007,GO:0045008,GO:0045471,GO:0051593,GO:0071276,GO:0140078,GO:1901291 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| OGG1 | hsa:4968 | path:hsa03410 | Base excision repair - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | OGG1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | OGG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | OGG1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | OGG1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | OGG1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | OGG1 | 16293709 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | OGG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFYA | OGG1 | 14688259 17989114 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNRPF | OGG1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKCA | OGG1 | 12034821 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| XRCC1 | OGG1 | 12933815 14525934 16713569 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| OGG1 | CHGB | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| OGG1 | ERCC8 | 25348397 | N/A | physical interaction | ComPPI |
| OGG1 | ERCC6 | 25348397 | N/A | physical interaction | ComPPI |
| OGG1 | ERCC6 | 25348397 | N/A | physical interaction | ComPPI |
| OGG1 | XPC | 16957781 24234451 25348397 27898060 | N/A | filter binding | ComPPI,IntAct,OmniPath |
| CAPN1 | OGG1 | 18294929 27898060 | inhibition | N/A | OmniPath |