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GENE：POLR2I

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLR2I
FullNmae RNA polymerase II subunit I
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9196
EnsembleID ENSG00000105258
Uniprot P36954

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLR2I autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLR2I GO:0001193,GO:0003676,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005665,GO:0005665,GO:0005730,GO:0006283,GO:0006366,GO:0006367,GO:0008270

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLR2I hsa:5438 path:hsa03020 RNA polymerase - Homo sapiens (human)
POLR2I hsa:5438 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLR2I hsa:5438 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMARCA4 POLR2I 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 POLR2I 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLR2I 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 POLR2I 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLR2I 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005A8A8D POLR2I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000079D48 POLR2I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005FDE70 POLR2I 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
POLR2E POLR2I 25361965 interaction type N/A PTMCode2
POLR2I POLR2E 25361965 interaction type N/A PTMCode2
POLR2I KAT2A 25361965 interaction type N/A PTMCode2
KAT2A POLR2I 25361965 interaction type N/A PTMCode2
POLR2I ELP3 25361965 interaction type N/A PTMCode2
ELP3 POLR2I 25361965 interaction type N/A PTMCode2
POLR2I CCNH 25361965 interaction type N/A PTMCode2
CCNH POLR2I 25361965 interaction type N/A PTMCode2
POLR2I GTF2E1 25361965 interaction type N/A PTMCode2
GTF2E1 POLR2I 25361965 interaction type N/A PTMCode2
POLR2I POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2I 25361965 interaction type N/A PTMCode2
POLR2I GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2I 25361965 interaction type N/A PTMCode2
POLR2I POLR2F 25361965 interaction type N/A PTMCode2
POLR2F POLR2I 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CUL5 POLR2I 25348397 N/A physical interaction ComPPI
POLR2L POLR2I 25348397 N/A physical interaction ComPPI
UXT POLR2I 25348397 N/A physical interaction ComPPI
MED21 POLR2I 25348397 N/A physical interaction ComPPI
DCUN1D1 POLR2I 25348397 N/A physical interaction ComPPI
SRC POLR2I 25348397 N/A physical interaction ComPPI
COPS5 POLR2I 25348397 N/A physical interaction ComPPI
CPNE2 POLR2I 25348397 N/A physical interaction ComPPI
PSMB9 POLR2I 25348397 N/A physical interaction ComPPI
KSR2 POLR2I 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
XPO1 POLR2I 25348397 N/A physical interaction ComPPI
TBCD POLR2I 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LMO2 POLR2I 25348397 N/A physical interaction ComPPI
POLR2E POLR2I 24234451 25348397 27193682 physical association physical interaction,electron tomography ComPPI,IntAct
POLR2A POLR2I 25348397 N/A physical interaction ComPPI
MED26 POLR2I 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUPT5H POLR2I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDKN2AIP POLR2I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOA POLR2I 25348397 N/A physical interaction ComPPI
ESR1 POLR2I 25348397 N/A physical interaction ComPPI
RECQL5 POLR2I 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
BRCA1 POLR2I 25348397 N/A physical interaction ComPPI
POLR2K POLR2I 25348397 N/A physical interaction ComPPI
RNGTT POLR2I 25348397 N/A physical interaction ComPPI
POLR2F POLR2I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2C POLR2I 25348397 N/A physical interaction ComPPI
POLR2G POLR2I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR1B POLR2I 25348397 N/A physical interaction ComPPI
MED19 POLR2I 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCIF1 POLR2I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2D POLR2I 25348397 N/A physical interaction ComPPI
ERCC2 POLR2I 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2H POLR2I 10567706 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2B POLR2I 25348397 N/A physical interaction ComPPI
POLR2I MED10 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2I MED29 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2I WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2I CPSF6 25348397 N/A physical interaction ComPPI
POLR2I GPN3 25348397 N/A physical interaction ComPPI
POLR2I PIH1D1 25348397 N/A physical interaction ComPPI
POLR2I RPRD1B 25348397 N/A physical interaction ComPPI
POLR2I MYZAP 25348397 N/A physical interaction ComPPI
POLR2I POLR2M 25348397 N/A physical interaction ComPPI
POLR2I SYDE1 25348397 N/A physical interaction ComPPI

Visualization










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