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GENE：POLR2L

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLR2L
FullNmae RNA polymerase II, I and III subunit L
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9199
EnsembleID ENSG00000177700
Uniprot P62875

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLR2L autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLR2L GO:0001054,GO:0001055,GO:0001056,GO:0003677,GO:0003899,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005665,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006356,GO:0006360,GO:0006366,GO:0006366,GO:0008270,GO:0042797

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLR2L hsa:5441 path:hsa03020 RNA polymerase - Homo sapiens (human)
POLR2L hsa:5441 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLR2L hsa:5441 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
POLR2L hsa:5441 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTCF POLR2L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLR2L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLR2L 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 POLR2L 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EC1BE POLR2L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 POLR2L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC POLR2L 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RPA1 POLR2L 25361965 interaction type N/A PTMCode2
POLR2L RPA1 25361965 interaction type N/A PTMCode2
PCBP1 POLR2L 25361965 interaction type N/A PTMCode2
POLR2L PCBP1 25361965 interaction type N/A PTMCode2
POLR2L UBL5 25361965 interaction type N/A PTMCode2
UBL5 POLR2L 25361965 interaction type N/A PTMCode2
POLR2L PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 POLR2L 25361965 interaction type N/A PTMCode2
POLR2L GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR3A 25361965 interaction type N/A PTMCode2
POLR3A POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR3F 25361965 interaction type N/A PTMCode2
POLR3F POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR2F 25361965 interaction type N/A PTMCode2
POLR2F POLR2L 25361965 interaction type N/A PTMCode2
POLR2B POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR2B 25361965 interaction type N/A PTMCode2
POLR2E POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR2E 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOSC5 POLR2L 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ZBTB14 POLR2L 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L COIL 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L TP53BP2 25348397 N/A two hybrid,physical interaction ComPPI
POLR2L PHC2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L SPAG5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L POLR2H 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2L POLR2D 10567706 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
POLR2L POLR2C 10567706 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2L POLR2E 14525934 24234451 25348397 27193682 9201987 physical association experimental interaction detection,physical interaction,electron tomography,in vitro ComPPI,HPRD,IntAct
POLR2L POLR2A 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2L POLR2B 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2L CCDC85B 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLR2L NFKBIB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
POLR2L CCN3 10474687 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
POLR2L MED10 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L MED29 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L MED19 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L MED28 25348397 N/A physical interaction ComPPI
POLR2L MED26 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L POLR2G 25348397 N/A physical interaction ComPPI
POLR2L POLR1A 19214185 24234451 25348397 association chromatography technology,physical interaction ComPPI,IntAct
POLR2L INTS5 25348397 N/A physical interaction ComPPI
POLR2L INTS6 25348397 N/A physical interaction ComPPI
POLR2L CHEK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POLR2L SNX7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POLR2L ESR1 25348397 N/A physical interaction ComPPI
POLR2L SRC 25348397 N/A physical interaction ComPPI
POLR2L PSMB9 25348397 N/A physical interaction ComPPI
POLR2L ELOA 25348397 N/A physical interaction ComPPI
POLR2L REL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L RPAP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L THAP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L L3MBTL3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POLR2L GPN3 25348397 N/A physical interaction ComPPI
POLR2L PIH1D1 25348397 N/A physical interaction ComPPI
POLR2L RPRD1B 25348397 N/A physical interaction ComPPI
POLR2L GPN2 25348397 N/A physical interaction ComPPI
POLR2L MYZAP 25348397 N/A physical interaction ComPPI
POLR2L POLR2M 25348397 N/A physical interaction ComPPI
POLR2L SKAP1 25348397 N/A physical interaction ComPPI
POLR2L POLR3D 25348397 N/A physical interaction ComPPI
POLR2L POLR1D 25348397 N/A physical interaction ComPPI
POLR2L POLR1D 25348397 N/A physical interaction ComPPI
POLR2L POLR2I 25348397 N/A physical interaction ComPPI
POLR2L IMP3 25348397 N/A physical interaction ComPPI
POLR2L POLR1B 25348397 N/A physical interaction ComPPI
POLR2L POLR1C 25348397 N/A physical interaction ComPPI
POLR2L POLR3C 25348397 N/A physical interaction ComPPI
POLR2L SMARCD1 25348397 N/A physical interaction ComPPI
POLR2L SNCA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L SUPT5H 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2L POLR3GL 25348397 N/A physical interaction ComPPI
POLR2L RCCD1 25348397 N/A physical interaction ComPPI
POLR2L LMO2 25348397 N/A physical interaction ComPPI
POLR2L ASB6 25348397 N/A physical interaction ComPPI
POLR2L TRIM25 25348397 N/A physical interaction ComPPI
POLR2L HIF1AN 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
POLR2L TRIP13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLR2L AGR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLR2L PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLR2L NACC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLR2L FAM217B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLR2L ERCC2 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
NEDD4 POLR2L 17996703 27898060 inhibition N/A OmniPath

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