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GENE：PPP2R5B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP2R5B
FullNmae protein phosphatase 2 regulatory subunit B'beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9310
EnsembleID ENSG00000068971
Uniprot Q15173

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP2R5B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP2R5B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP2R5B GO:0000159,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006470,GO:0007165,GO:0010976,GO:0019888,GO:0031334,GO:0031952,GO:0045944,GO:0050730,GO:0051388,GO:0070317,GO:0071363,GO:0072542

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP2R5B hsa:5526 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04110 Cell cycle - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PPP2R5B hsa:5526 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP2R5B CHEK2 20005715 interaction type N/A PSP
PPP2R5B PPP2CA 18782753 18988627 20005715 21071413 7592815 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PPP2R5B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PPP2R5B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPP2R5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPP2R5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP2R5B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PPP2R5B PPP2CA 25361965 interaction type N/A PTMCode2
PPP2CA PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R5B AXIN1 25361965 interaction type N/A PTMCode2
AXIN1 PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R5B PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R5B PPP2R1A 25361965 interaction type N/A PTMCode2
PPP2R1A PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R5B PPM1A 25361965 interaction type N/A PTMCode2
PPM1A PPP2R5B 25361965 interaction type N/A PTMCode2
PPP2R5B CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 PPP2R5B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPP2R1A PPP2R5B 18782753 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 PPP2R5B 25348397 N/A physical interaction ComPPI
PIM1 PPP2R5B 25348397 N/A physical interaction ComPPI
ARHGEF2 PPP2R5B 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AXIN1 PPP2R5B 10698523 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IER3 PPP2R5B 16456541 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction,in vitro ComPPI,IntAct
PPP2CA PPP2R5B 14525934 16456541 18782753 24234451 25348397 28330616 7592815 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CHEK2 PPP2R5B 14525934 15380617 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
WNT3A PPP2R5B 25348397 N/A physical interaction ComPPI
CCNG2 PPP2R5B 25348397 N/A physical interaction ComPPI
PPP2R1B PPP2R5B 25348397 N/A physical interaction ComPPI
DUSP19 PPP2R5B 25348397 N/A physical interaction ComPPI
PPP2R5B FAM43A 25348397 N/A physical interaction ComPPI
PPP2R5B DZIP1 21878643 24234451 25348397 physical association two hybrid ComPPI,IntAct
PPP2R5B KSR1 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SGO1 PPP2R5B 14525934 16541024 16541025 N/A experimental interaction detection HPRD
PPP2R5B CASP3 15569672 27898060 stimulant N/A OmniPath
PPP2R5B BCL2 18845789 27898060 inhibition N/A OmniPath
PPP2R5B AKT1 16495456 27898060 inhibition N/A OmniPath

Visualization










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