GENE：PTDSS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PTDSS1 |
| FullNmae | phosphatidylserine synthase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9587 |
| EnsembleID | ENSG00000156471 |
| Uniprot | P48651 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PTDSS1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PTDSS1 | GO:0005789,GO:0005789,GO:0006659,GO:0006659,GO:0006659,GO:0016020,GO:0016020,GO:0016740,GO:0106245,GO:0106245,GO:0106258,GO:0106258 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PTDSS1 | hsa:9791 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| PTDSS1 | hsa:9791 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PTDSS1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PTDSS1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PTDSS1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PTDSS1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PTDSS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | PTDSS1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000070B1D | PTDSS1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002F5FEE | PTDSS1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | PTDSS1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005194EC | PTDSS1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | PTDSS1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003003B4 | PTDSS1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERBB2 | PTDSS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KSR2 | PTDSS1 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HNRNPL | PTDSS1 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | PTDSS1 | 25348397 | N/A | physical interaction | ComPPI |
| CREB3 | PTDSS1 | 21516116 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TRIM25 | PTDSS1 | 25348397 | N/A | physical interaction | ComPPI |
| PLK4 | PTDSS1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ELAVL1 | PTDSS1 | 25348397 | N/A | physical interaction | ComPPI |
| RRP1B | PTDSS1 | 20926688 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| STAU1 | PTDSS1 | 25348397 | N/A | physical interaction | ComPPI |
| PTDSS1 | TSHR | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| PTDSS1 | SCARB1 | 12016218 27898060 8999945 | stimulant | N/A | OmniPath |
| PTDSS1 | JMJD6 | 10811223 27898060 | stimulant | N/A | OmniPath |