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GENE：UPF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UPF2
FullNmae UPF2 regulator of nonsense mediated mRNA decay
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17854
EnsembleID ENSG00000151461
Uniprot Q9HAU5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UPF2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UPF2 GO:0000184,GO:0000184,GO:0000184,GO:0001889,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005844,GO:0006406,GO:0031100,GO:0035145,GO:0035145,GO:0036464,GO:0042162,GO:0048471

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UPF2 hsa:26019 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
UPF2 hsa:26019 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMG1 UPF2 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
UPF1 UPF2 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 UPF2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 UPF2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 UPF2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UPF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 UPF2 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 UPF2 18668040 20584899 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase

Source Target Pmid Interactiontype Methods Database
ZNF408 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
KRT18 UPF2 25348397 N/A physical interaction ComPPI
SNW1 UPF2 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L UPF2 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HBZ UPF2 25348397 N/A physical interaction ComPPI
RPS7 UPF2 25348397 N/A physical interaction ComPPI
LDHA UPF2 25348397 N/A physical interaction ComPPI
TK1 UPF2 25348397 N/A physical interaction ComPPI
AGPAT1 UPF2 25348397 N/A physical interaction ComPPI
ZBTB48 UPF2 25348397 N/A physical interaction ComPPI
LSM1 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RPS15 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAP1LC3B UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MRPL40 UPF2 25348397 N/A physical interaction ComPPI
EXOSC1 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PITX1 UPF2 25348397 N/A physical interaction ComPPI
EXOSC8 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RBM8A UPF2 16452507 19417104 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN UPF2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGA1 UPF2 25348397 N/A physical interaction ComPPI
SMARCD1 UPF2 25348397 N/A physical interaction ComPPI
EIF4G1 UPF2 15361857 24234451 25348397 association coimmunoprecipitation,in vivo ComPPI,IntAct
ITGB1 UPF2 25348397 N/A physical interaction ComPPI
NTRK1 UPF2 25348397 N/A physical interaction ComPPI
ENO1 UPF2 25348397 N/A physical interaction ComPPI
E4F1 UPF2 25348397 N/A physical interaction ComPPI
CALR UPF2 25348397 N/A physical interaction ComPPI
XRN2 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DCP1B UPF2 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZFP36 UPF2 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BLM UPF2 25348397 N/A physical interaction ComPPI
XPO1 UPF2 25348397 N/A physical interaction ComPPI
SMG1 UPF2 11544179 14525934 16452507 18256688 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
TRIP10 UPF2 25348397 N/A physical interaction ComPPI
RPS6 UPF2 25348397 N/A physical interaction ComPPI
RPS25 UPF2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 UPF3B 11163187 12417715 12718880 14525934 14527413 15231747 16452507 16601204 18066079 19503078 20479275 22522823 24234451 25348397 26344197 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,transmission electron microscopy,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct,OmniPath
UPF2 UPF1 11073994 11163187 11544179 12417715 12723973 14525934 14527413 15680326 16086026 16452507 16488880 17469741 18066079 18256688 19150429 19417104 19478851 19503078 19556969 20371770 21145460 24234451 24778252 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,nuclear magnetic resonance,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,atpase assay,two hybrid ComPPI,HPRD,IntAct,OmniPath
UPF2 EIF4A1 11073994 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
UPF2 RPL5 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 XRN1 14525934 14527413 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UPF2 NOB1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 DCP2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 MTREX 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 EXOSC10 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF2 EXOSC4 14525934 14527413 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UPF2 EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
UPF2 PHB2 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UPF2 EXOSC2 25348397 N/A physical interaction ComPPI
UPF2 PARN 25348397 N/A physical interaction ComPPI
UPF2 UPF3A 11163187 19503078 20479275 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
UPF2 POLD1 25348397 N/A physical interaction ComPPI
UPF2 ELAVL1 25348397 N/A physical interaction ComPPI
UPF2 RNPS1 11546874 16209946 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF2 PAIP1 25348397 N/A physical interaction ComPPI
UPF2 PRPF31 25348397 N/A physical interaction ComPPI
UPF2 MMS22L 25348397 N/A physical interaction ComPPI
UPF2 HBB 25348397 N/A physical interaction ComPPI
UPF2 TP63 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UPF2 RPL13 25348397 N/A physical interaction ComPPI
UPF2 SERBP1 25348397 N/A physical interaction ComPPI
UPF2 TUBB2A 25348397 N/A physical interaction ComPPI
UPF2 ATP1B3 25348397 N/A physical interaction ComPPI
UPF2 TOP3B 25348397 N/A physical interaction ComPPI
UPF2 HSF2BP 25348397 N/A physical interaction ComPPI
UPF2 CIZ1 25348397 N/A physical interaction ComPPI
UPF2 NOMO1 25348397 N/A physical interaction ComPPI
UPF2 WNK1 25348397 N/A physical interaction ComPPI
UPF2 ZGPAT 25348397 N/A physical interaction ComPPI
UPF2 SUMO3 25348397 N/A physical interaction ComPPI
UPF2 TYMS 25348397 N/A physical interaction ComPPI
UPF2 NDUFA7 25348397 N/A physical interaction ComPPI
UPF2 RPL8 25348397 N/A physical interaction ComPPI
UPF2 CYBA 25348397 N/A physical interaction ComPPI
UPF2 SERF2 25348397 N/A physical interaction ComPPI
UPF2 CENPU 25348397 N/A physical interaction ComPPI
UPF2 GADD45GIP1 25348397 N/A physical interaction ComPPI
UPF2 NOP53 25348397 N/A physical interaction ComPPI
UPF2 MTERF3 25348397 N/A physical interaction ComPPI
UPF2 ZNF44 25348397 N/A physical interaction ComPPI
UPF2 RSRC2 25348397 N/A physical interaction ComPPI
UPF2 TNNI2 25348397 N/A physical interaction ComPPI
UPF2 ABCF2 25348397 N/A physical interaction ComPPI
UPF2 DPF2 25348397 N/A physical interaction ComPPI
UPF2 MYB 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
UPF2 MAP1A 14525934 15231747 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
UPF2 ART4 25348397 N/A physical interaction ComPPI
UPF2 LGR4 25348397 N/A physical interaction ComPPI
UPF2 PUF60 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UPF2 SMARCD2 25348397 N/A physical interaction ComPPI
UPF2 SMARCD3 25348397 N/A physical interaction ComPPI
UPF2 KIF15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF2 INTS6 17469741 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UPF2 EIF3B 25348397 N/A anti bait coimmunoprecipitation ComPPI
UPF2 SCHIP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
UPF2 AKTIP 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
UPF2 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
UPF2 CASC3 20479275 22522823 24234451 25348397 physical association transmission electron microscopy,cosedimentation through density gradient,molecular sieving,electron tomography ComPPI,IntAct
UPF2 PSMD9 24234451 25009770 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
SRRM1 UPF2 11546874 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF UPF2 25348397 N/A physical interaction ComPPI
RRP7A UPF2 25348397 N/A physical interaction ComPPI
COMTD1 UPF2 25348397 N/A physical interaction ComPPI
UPF2 UPF2 11073994 12723973 14525934 15004547 15231747 24234451 physical association two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
EIF1 UPF2 11073994 14525934 N/A experimental interaction detection,two hybrid HPRD

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