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GENE：UPF3B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UPF3B
FullNmae UPF3B regulator of nonsense mediated mRNA decay
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20439
EnsembleID ENSG00000125351
Uniprot Q9BZI7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UPF3B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UPF3B GO:0000184,GO:0000184,GO:0000184,GO:0000184,GO:0003723,GO:0003729,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0007420,GO:0031175,GO:0034451,GO:0035145,GO:0043025,GO:0045666,GO:0045727,GO:0045727,GO:0051028

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UPF3B hsa:65109 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
UPF3B hsa:65109 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
UPF1 UPF3B 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 UPF3B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 UPF3B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA UPF3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UPF3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SATB2 UPF3B 23925499 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 UPF3B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 UPF3B 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
XRN1 UPF3B 25361965 interaction type N/A PTMCode2
UPF3B XRN1 25361965 interaction type N/A PTMCode2
CASC3 UPF3B 25361965 interaction type N/A PTMCode2
UPF3B CASC3 25361965 interaction type N/A PTMCode2
UPF3B EXOSC4 25361965 interaction type N/A PTMCode2
EXOSC4 UPF3B 25361965 interaction type N/A PTMCode2
UPF3B MAGOH 25361965 interaction type N/A PTMCode2
MAGOH UPF3B 25361965 interaction type N/A PTMCode2
UPF3B UPF3A 25361965 interaction type N/A PTMCode2
UPF3A UPF3B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CUL5 UPF3B 25348397 N/A physical interaction ComPPI
CIAO1 UPF3B 25348397 N/A physical interaction ComPPI
SNRPA1 UPF3B 25348397 N/A physical interaction ComPPI
H2BC4 UPF3B 25348397 N/A physical interaction ComPPI
RBM8A UPF3B 11546873 11546874 12718880 14525934 16209946 16452507 16601204 23084401 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
JUN UPF3B 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 UPF3B 25348397 N/A physical interaction ComPPI
EIF4G1 UPF3B 15361857 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
RBBP6 UPF3B 14525934 18851979 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
WBP11 UPF3B 25348397 N/A physical interaction ComPPI
ITGB3BP UPF3B 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EIF6 UPF3B 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
XPO1 UPF3B 25348397 N/A physical interaction ComPPI
SMG1 UPF3B 16452507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RLIM UPF3B 25348397 N/A physical interaction ComPPI
UPF2 UPF3B 11163187 12417715 12718880 14525934 14527413 15231747 16452507 16601204 18066079 19503078 20479275 22522823 24234451 25348397 26344197 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,transmission electron microscopy,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct,OmniPath
SMG6 UPF3B 25348397 N/A physical interaction ComPPI
MCRS1 UPF3B 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMG5 UPF3B 16601204 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC4A8 UPF3B 25348397 N/A physical interaction ComPPI
UPF3B UPF1 11163187 12417715 12723973 14525934 15680326 16601204 19417104 19478851 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
UPF3B XRN1 14525934 14527413 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UPF3B EXOSC4 14525934 14527413 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UPF3B UPF3A 25348397 N/A pull down,physical interaction,physical interaction ComPPI
UPF3B HBB 25348397 N/A physical interaction ComPPI
UPF3B USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B CAND1 25348397 N/A physical interaction ComPPI
UPF3B RNPS1 11546874 16209946 16601204 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B NXF1 11546873 11546874 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B PYM1 25348397 N/A physical interaction ComPPI
UPF3B SART1 25348397 N/A physical interaction ComPPI
UPF3B TOP2A 25348397 N/A physical interaction ComPPI
UPF3B HECW2 25348397 N/A physical interaction ComPPI
UPF3B STAU1 25348397 N/A physical interaction ComPPI
UPF3B NCBP1 18423201 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B SLC25A11 25348397 N/A physical interaction ComPPI
UPF3B NR2E1 25348397 N/A physical interaction ComPPI
UPF3B YEATS4 25348397 N/A physical interaction ComPPI
UPF3B CASC3 16601204 19478851 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
UPF3B MAGOH 16209946 16601204 19410547 19478851 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
UPF3B MEPCE 25348397 N/A physical interaction ComPPI
UPF3B UTP20 25348397 N/A physical interaction ComPPI
UPF3B H2BC11 25348397 N/A physical interaction ComPPI
UPF3B SRPK2 25348397 N/A physical interaction ComPPI
UPF3B SEC61A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B NKAP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3B DEFA5 25348397 N/A physical interaction ComPPI
UPF3B FADS3 25348397 N/A physical interaction ComPPI
UPF3B ZNF280A 25348397 N/A physical interaction ComPPI
UPF3B HNRNPA1 11546873 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
UPF3B ALYREF 11546873 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
UPF3B THRAP3 20123736 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TTC19 UPF3B 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF4A3 UPF3B 15361857 16209946 16601204 19410547 19478851 19884259 22961380 23084401 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,molecular sieving,physical interaction,tandem affinity purification ComPPI,IntAct,OmniPath
CCDC60 UPF3B 25348397 N/A physical interaction ComPPI
UPF3B UPF3B 12093754 14525934 N/A experimental interaction detection HPRD
NOMO1 UPF3B 24234451 30021884 physical association cross-linking study IntAct

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