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GENE：DET1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DET1
FullNmae DET1 partner of COP1 E3 ubiquitin ligase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25477
EnsembleID ENSG00000140543
Uniprot Q7L5Y6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DET1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DET1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DET1 GO:0005515,GO:0005634,GO:0016567,GO:0016567,GO:0031461,GO:0031464,GO:0031625,GO:0031625,GO:0032436,GO:0032436,GO:0044877,GO:0065003,GO:0080008,GO:1990756,GO:1990756

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DET1 hsa:55070 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 DET1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 DET1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DET1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 DET1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 DET1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DET1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DET1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DET1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DET1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DET1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 DET1 18367535 20584899 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000338542 DET1 18367535 20584899 25416803 26497687 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 DET1 25348397 N/A physical interaction ComPPI
JUNB DET1 25348397 N/A physical interaction ComPPI
HSP90AB1 DET1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
UBE2E2 DET1 25348397 N/A physical interaction ComPPI
UBE2E3 DET1 25348397 N/A physical interaction ComPPI
ETS2 DET1 25348397 N/A physical interaction ComPPI
ETV1 DET1 25348397 N/A physical interaction ComPPI
FOSL2 DET1 25348397 N/A physical interaction ComPPI
COPS5 DET1 25348397 N/A physical interaction ComPPI
COP1 DET1 14525934 14739464 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RBX1 DET1 25348397 N/A physical interaction ComPPI
HSP90AA1 DET1 25348397 N/A physical interaction ComPPI
STIP1 DET1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TRIB1 DET1 25348397 N/A physical interaction ComPPI
CACYBP DET1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
COPS2 DET1 25348397 N/A physical interaction ComPPI
CUL4B DET1 25348397 N/A physical interaction ComPPI
MDM2 DET1 25348397 N/A physical interaction ComPPI
CUL4A DET1 25348397 N/A physical interaction ComPPI
COPS3 DET1 25348397 N/A physical interaction ComPPI
COPS4 DET1 25348397 N/A physical interaction ComPPI
GPS1 DET1 25348397 N/A physical interaction ComPPI
COPS6 DET1 25348397 N/A physical interaction ComPPI
COPS7A DET1 25348397 N/A physical interaction ComPPI
RNF14 DET1 25348397 N/A physical interaction ComPPI
ETV5 DET1 25348397 N/A physical interaction ComPPI
DDB1 DET1 14525934 14739464 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2E1 DET1 25348397 N/A physical interaction ComPPI
COPS7B DET1 25348397 N/A physical interaction ComPPI
BAG2 DET1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DET1 FOS 25348397 N/A physical interaction ComPPI
DET1 TRIB2 25348397 N/A physical interaction ComPPI
DET1 STK40 25348397 N/A physical interaction ComPPI
DET1 FKBP5 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DDA1 DET1 25348397 N/A physical interaction ComPPI

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