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GENE：DNAJB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DNAJB2
FullNmae DnaJ heat shock protein family (Hsp40) member B2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5228
EnsembleID ENSG00000135924
Uniprot P25686

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DNAJB2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DNAJB2 GO:0001671,GO:0001671,GO:0005515,GO:0005634,GO:0005789,GO:0005829,GO:0005829,GO:0006986,GO:0008285,GO:0030308,GO:0030433,GO:0030544,GO:0030544,GO:0031396,GO:0031965,GO:0032091,GO:0032436,GO:0032436,GO:0032781,GO:0042026,GO:0042026,GO:0043130,GO:0051082,GO:0051082,GO:0051087,GO:0061077,GO:0061077,GO:0070050,GO:0090084,GO:0140036,GO:1903644

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DNAJB2 hsa:3300 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
UBC DNAJB2 19285159 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DNAJB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DNAJB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DNAJB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A DNAJB2 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 DNAJB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DNAJB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DNAJB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DNAJB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 DNAJB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE DNAJB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000254A6 DNAJB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 DNAJB2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 DNAJB2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSPA8 DNAJB2 25348397 N/A physical interaction ComPPI
GET3 DNAJB2 25348397 N/A physical interaction ComPPI
SMAD4 DNAJB2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RNF115 DNAJB2 25348397 N/A physical interaction ComPPI
ERBB2 DNAJB2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
UBB DNAJB2 25348397 N/A two hybrid,physical interaction ComPPI
UBC DNAJB2 25348397 N/A two hybrid,physical interaction ComPPI
RPS27A DNAJB2 14525934 15936278 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
UBA52 DNAJB2 14525934 15936278 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
UBE2N DNAJB2 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
PSMA6 DNAJB2 25348397 N/A physical interaction ComPPI
DNAJB2 UBQLN1 14525934 17082820 24234451 25348397 colocalization,physical association experimental interaction detection,pull down,physical interaction,imaging technique,in vitro ComPPI,HPRD,IntAct
DNAJB2 HSPA4 25348397 N/A physical interaction ComPPI
DNAJB2 ATXN3 25348397 N/A physical interaction ComPPI
DNAJB2 RHO 12754272 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DNAJB2 HDAC11 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNAJB2 FBXO25 25348397 N/A physical interaction ComPPI
DNAJB2 MAP3K1 25348397 N/A physical interaction ComPPI
DNAJB2 DNAJB8 25348397 N/A physical interaction ComPPI
DNAJB2 NSMCE4A 25348397 N/A physical interaction ComPPI
DNAJB2 DNAJB6 25348397 N/A physical interaction ComPPI
DNAJB2 GLB1 25348397 N/A physical interaction ComPPI
DNAJB2 TRO 25348397 N/A physical interaction ComPPI
DNAJB2 ATP7A 25348397 N/A physical interaction ComPPI
DNAJB2 ATP7B 25348397 N/A physical interaction ComPPI
DNAJB2 ARFGEF2 25348397 N/A physical interaction ComPPI
DNAJB2 CTSA 25348397 N/A physical interaction ComPPI
DNAJB2 PJA1 25348397 N/A physical interaction ComPPI
DNAJB2 FAM83H 25348397 N/A physical interaction ComPPI
DNAJB2 MORF4L1 25348397 N/A physical interaction ComPPI
DNAJB2 BIRC2 25348397 N/A physical interaction ComPPI
DNAJB2 RNF19B 25348397 N/A physical interaction ComPPI
DNAJB2 CYHR1 25348397 N/A physical interaction ComPPI
DNAJB2 RFWD3 25348397 N/A physical interaction ComPPI
DNAJB2 KCTD3 25348397 N/A physical interaction ComPPI
DNAJB2 TRAF2 25348397 N/A physical interaction ComPPI
DNAJB2 LACC1 25348397 N/A physical interaction ComPPI
DNAJB2 NEK4 25348397 N/A physical interaction ComPPI
DNAJB2 ESRRB 25348397 N/A physical interaction ComPPI
DNAJB2 TARDBP 25348397 N/A physical interaction ComPPI
DNAJB2 CSNK2A1 25348397 N/A physical interaction ComPPI
DNAJB2 RLIM 25348397 N/A physical interaction ComPPI
DNAJB2 CYLD 25348397 N/A physical interaction ComPPI
DNAJB2 CFTR 25348397 N/A physical interaction ComPPI
DNAJB2 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DNAJB2 PSMD2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DNAJB2 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
DNAJB2 UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
DNAJB2 SHLD3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009AFE0D DNAJB2 27087310 direct interaction,inhibition N/A NPInter

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