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GENE：ADAM17

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADAM17
FullNmae ADAM metallopeptidase domain 17
LocusType gene with protein product
Status Approved
HGNC_id HGNC:195
EnsembleID ENSG00000151694
Uniprot P78536

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADAM17 necroptosis 34919140 Moreover, we reveal that ADAM17-mediated TNFR1 ectodomain shedding and subsequent processing by the γ-secretase complex is required for the induction of TNF-induced necroptosis. retulator signature
ADAM17 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ADAM17 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ADAM17 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADAM17 GO:0000139,GO:0001666,GO:0001934,GO:0002446,GO:0002467,GO:0002690,GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0004222,GO:0005112,GO:0005138,GO:0005178,GO:0005515,GO:0005737,GO:0005788,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0005925,GO:0006508,GO:0006509,GO:0006509,GO:0006509,GO:0007155,GO:0007219,GO:0007220,GO:0008233,GO:0008237,GO:0008237,GO:0008284,GO:0009410,GO:0009986,GO:0010820,GO:0015629,GO:0016020,GO:0016324,GO:0016485,GO:0017124,GO:0030165,GO:0030183,GO:0030307,GO:0030335,GO:0030335,GO:0030511,GO:0030512,GO:0032496,GO:0032587,GO:0032722,GO:0033025,GO:0033077,GO:0033627,GO:0035313,GO:0035624,GO:0042987,GO:0043120,GO:0043536,GO:0045121,GO:0045737,GO:0045741,GO:0045741,GO:0046872,GO:0048536,GO:0048870,GO:0050830,GO:0071403,GO:0071679,GO:0120163,GO:1900087,GO:1902945,GO:1903265,GO:1905564

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ADAM17 hsa:6868 path:hsa04148 Efferocytosis - Homo sapiens (human)
ADAM17 hsa:6868 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
ADAM17 hsa:6868 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ADAM17 hsa:6868 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
ADAM17 hsa:6868 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADAM10 ADAM17 18676862 19601831 19704010 19726682 22006996 26192618 association N/A ACSN
ADAM17 DLL1 18676862 19601831 19704010 19726682 22006996 26192618 interaction type N/A ACSN
ADAM17 NOTCH1 10882063 18676862 18988627 19601831 19704010 19726682 22006996 23331499 26192618 9620803 interaction type N/A ACSN,SignaLink,SignaLink
ADAM17 TNF 18676862 19704010 19726682 26192618 interaction type N/A ACSN
MAPK3 ADAM17 12058067 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK1 ADAM17 12058067 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADAM17 MAPK1 12058067 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADAM17 MAPK3 12058067 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADAM17 IL6R 23180781 24790088 physical association pull down InnateDB
ADAM17 IL1R2 23180781 24790088 physical association pull down InnateDB
GHR ADAM17 24243840 29145629 cleavage reaction inferred by curator Reactome
ADAM17 ADAM17 10882063 26467481 cleavage reaction,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR ADAM17 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ADAM17 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 ADAM17 19772640 22705645 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ADAM17 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ADAM17 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ADAM17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ADAM17 19772640 22705645 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC ADAM17 19296470 19935707 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 ADAM17 23441135 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00003380CC ADAM17 19296470 19726678 19935707 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 ADAM17 23076445 23441135 23548270 23824327 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000000C73C ADAM17 24780186 24813629 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 ADAM17 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 ADAM17 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ADAM17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 ADAM17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 ADAM17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ADAM17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002DD349 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 ADAM17 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 ADAM17 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 ADAM17 25416803 26617808 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD ADAM17 22135298 phosphorylation N/A PhosphoSite
MAPK3 ADAM17 22135298 phosphorylation N/A PhosphoSite
MAPK14 ADAM17 22135298 phosphorylation N/A PhosphoSite
MAPK1 ADAM17 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCE ADAM17 22135298 phosphorylation N/A PhosphoSite
PRKCA ADAM17 22135298 phosphorylation N/A PhosphoSite
ADAM17 MAPK1 25361965 interaction type N/A PTMCode2
TGFA ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 TGFA 25361965 interaction type N/A PTMCode2
ADAM17 ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 TNF 25361965 interaction type N/A PTMCode2
TNF ADAM17 25361965 interaction type N/A PTMCode2
NOTCH1 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 NOTCH1 25361965 interaction type N/A PTMCode2
MAD2L2 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 MAD2L2 25361965 interaction type N/A PTMCode2
APP ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 APP 25361965 interaction type N/A PTMCode2
TIMP3 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 TIMP3 25361965 interaction type N/A PTMCode2
TNFSF11 ADAM17 25361965 interaction type N/A PTMCode2
ADAM17 TNFSF11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAD2L2 ADAM17 10527948 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK1 ADAM17 25348397 N/A physical interaction ComPPI
ERBB4 ADAM17 14525934 15534001 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC ADAM17 16641105 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NOTCH1 ADAM17 10882063 14525934 25348397 9620803 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FHL2 ADAM17 14525934 16619241 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ITGB1 ADAM17 22413019 24234451 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
PDIA3 ADAM17 17170699 24234451 25348397 disulfide bond anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDH1 ADAM17 25348397 N/A physical interaction ComPPI
PDPK1 ADAM17 25348397 N/A phosphorylation reaction,protein kinase assay,protein kinase assay ComPPI
TNFRSF1A ADAM17 25348397 N/A physical interaction ComPPI
PXN ADAM17 25348397 N/A physical interaction ComPPI
TNFSF11 ADAM17 10224132 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CFTR ADAM17 25348397 N/A physical interaction ComPPI
TNF ADAM17 10799478 12135369 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DLG1 ADAM17 12668732 14525934 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,fluorescence microscopy,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
TIMP3 ADAM17 12044879 14525934 19666115 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,OmniPath
ADAM17 MAD2L1 10527948 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ADAM17 SH3D19 14525934 15280379 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADAM17 TGFA 11823465 14525934 24234451 25241761 25348397 27898060 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
ADAM17 FBXO6 25348397 N/A physical interaction ComPPI
ADAM17 TNFRSF1B 25348397 N/A physical interaction ComPPI
ADAM17 EED 25348397 N/A physical interaction ComPPI
ADAM17 PTCH1 25348397 N/A physical interaction ComPPI
ADAM17 SDK2 25348397 N/A physical interaction ComPPI
ADAM17 LMAN2L 25348397 N/A physical interaction ComPPI
ADAM17 INSL5 25348397 N/A physical interaction ComPPI
ADAM17 ST8SIA4 25348397 N/A physical interaction ComPPI
ADAM17 LRRC3 25348397 N/A physical interaction ComPPI
ADAM17 PTPN3 12207026 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,two hybrid ComPPI,HPRD,IntAct
ADAM17 APP 24234451 25348397 27898060 9774383 cleavage reaction protease assay ComPPI,IntAct,OmniPath
ADAM17 JAG1 23375636 24234451 25348397 27898060 N/A cleavage assay ComPPI,IntAct,OmniPath
ADAM17 IL6R 24790088 27898060 N/A N/A OmniPath
MAPK3 ADAM17 12058067 27898060 stimulant N/A OmniPath
MAPK14 ADAM17 12058067 18187448 18722532 20188673 21570469 21586567 23955714 27898060 N/A N/A OmniPath
ADAM17 TNF 10799478 12135369 27898060 9034190 stimulant N/A OmniPath
ADAM17 IL1R2 24790088 27898060 N/A N/A OmniPath
SP1 ADAM17 19772640 27898060 stimulant N/A OmniPath
ADAM17 MAPK1 12058067 27898060 N/A N/A OmniPath
PAK1 ADAM17 12621058 27898060 N/A N/A OmniPath
ADAM17 NOTCH1 10882063 27898060 9620803 stimulant N/A OmniPath
ADAM17 MUC1 12441351 27898060 inhibition N/A OmniPath
PTPN3 ADAM17 12207026 27898060 N/A N/A OmniPath

Visualization










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