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GENE：HDDC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HDDC2
FullNmae HD domain containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21078
EnsembleID ENSG00000111906
Uniprot Q7Z4H3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HDDC2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HDDC2 GO:0002953,GO:0005515,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HDDC2 hsa:51020 path:hsa00230 Purine metabolism - Homo sapiens (human)
HDDC2 hsa:51020 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
HDDC2 hsa:51020 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HDDC2 hsa:51020 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR HDDC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 HDDC2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HDDC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HDDC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HDDC2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HDDC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D HDDC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 HDDC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000032FC1A HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E HDDC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC HDDC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C HDDC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 HDDC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004DEA91 HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 HDDC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 HDDC2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DUSP12 HDDC2 25348397 N/A physical interaction ComPPI
POMC HDDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DUSP1 HDDC2 25348397 N/A physical interaction ComPPI
DUSP6 HDDC2 25348397 N/A physical interaction ComPPI
DUSP19 HDDC2 25348397 N/A physical interaction ComPPI
LCN2 HDDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IKBKG HDDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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