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GENE：MAP4K2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP4K2
FullNmae mitogen-activated protein kinase kinase kinase kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6864
EnsembleID ENSG00000168067
Uniprot Q12851

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP4K2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP4K2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP4K2 GO:0000139,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006468,GO:0006903,GO:0006955,GO:0007254,GO:0008349,GO:0016323,GO:0031435,GO:0035556,GO:0035556,GO:0043507,GO:0045087,GO:0046330,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP4K2 hsa:5871 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP4K2 MAP4K2 26467481 7515885 9712898 bind,up-regulates N/A Signor
MAP4K2 MAP3K1 23331499 7515885 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
TRAF2 MAP4K2 20005715 interaction type N/A PSP
TRAF2 MAP4K2 20005715 20005715 21071413 9712898 9712898 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP4K2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP4K2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA MAP4K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP4K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP4K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP4K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP4K2 14612449 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP4K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MAP4K2 14612449 trascriptional regulation,stimulation inferred by curator TFlink
PDHX MAP4K2 8866550 trascriptional regulation,stimulation inferred by curator TFlink
PDX1 MAP4K2 8866550 trascriptional regulation,stimulation inferred by curator TFlink
USF1 MAP4K2 9677331 trascriptional regulation,stimulation inferred by curator TFlink
AR MAP4K2 N/A trascriptional regulation,stimulation inferred by curator TFlink
PAX6 MAP4K2 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG MAP4K2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 MAP4K2 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS0000475586 MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 MAP4K2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 MAP4K2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 MAP4K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC MAP4K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C MAP4K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MAP4K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B MAP4K2 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP4K2 PRH1 22135298 phosphorylation N/A PhosphoSite
MAP4K2 RAB10 25361965 interaction type N/A PTMCode2
RAB10 MAP4K2 25361965 interaction type N/A PTMCode2
MAP4K2 MAP3K11 25361965 interaction type N/A PTMCode2
MAP3K11 MAP4K2 25361965 interaction type N/A PTMCode2
MAP4K2 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSP90AB1 MAP4K2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RAB8A MAP4K2 14525934 25348397 8643544 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP4K2 MAP3K11 11784851 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP4K2 TRAF2 14525934 25348397 9712898 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP4K2 MAP3K1 11784851 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP4K2 MAP2K4 25348397 N/A physical interaction ComPPI
MAP4K2 HNRNPA2B1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 XRCC6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 SERPINA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 SNRNP35 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 NACAD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 DEFB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 PRDX4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K2 POT1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
MAP4K2 HSP90AA1 25348397 N/A physical interaction ComPPI
MAP4K2 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP4K2 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PKM MAP4K2 25348397 N/A protein kinase assay ComPPI
MAP4K2 SCNN1A 16174865 27898060 N/A N/A OmniPath
TRAF2 MAP4K2 27898060 9712898 stimulant N/A OmniPath
MAP4K2 MAP3K1 11784851 27898060 7515885 9712898 stimulant N/A OmniPath
MAPK8IP1 MAP4K2 10702297 27898060 inhibition N/A OmniPath
MAP4K2 PRH1 10684652 27898060 N/A N/A OmniPath
MAP4K2 SELP 27898060 7691235 N/A N/A OmniPath

Visualization










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