GENE:MAP4K2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | MAP4K2 |
FullNmae | mitogen-activated protein kinase kinase kinase kinase 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:6864 |
EnsembleID | ENSG00000168067 |
Uniprot | Q12851 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
MAP4K2 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MAP4K2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
MAP4K2 | GO:0000139,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0006468,GO:0006468,GO:0006903,GO:0006955,GO:0007254,GO:0008349,GO:0016323,GO:0031435,GO:0035556,GO:0035556,GO:0043507,GO:0045087,GO:0046330,GO:0106310 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
MAP4K2 | hsa:5871 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ETS1 | MAP4K2 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | MAP4K2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
CEBPA | MAP4K2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | MAP4K2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | MAP4K2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | MAP4K2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | MAP4K2 | 14612449 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | MAP4K2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HIF1A | MAP4K2 | 14612449 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PDHX | MAP4K2 | 8866550 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PDX1 | MAP4K2 | 8866550 | trascriptional regulation,stimulation | inferred by curator | TFlink |
USF1 | MAP4K2 | 9677331 | trascriptional regulation,stimulation | inferred by curator | TFlink |
AR | MAP4K2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
PAX6 | MAP4K2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
PPARG | MAP4K2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00004F4657 | MAP4K2 | 22942087 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000475586 | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F6E49 | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000007D64A | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F0F49 | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000040EE1D | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041CB9C | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000171CD1 | MAP4K2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000CBE63 | MAP4K2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000221168 | MAP4K2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003380CC | MAP4K2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005CC20C | MAP4K2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075C4B1 | MAP4K2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000032FC1A | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000486E0B | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000047A67D | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F4AC3 | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C5BAA | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000AA464 | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003E226A | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001A122A | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000020579D | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000913AC | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000003575B | MAP4K2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MAP4K2 | PRH1 | 22135298 | phosphorylation | N/A | PhosphoSite |
MAP4K2 | RAB10 | 25361965 | interaction type | N/A | PTMCode2 |
RAB10 | MAP4K2 | 25361965 | interaction type | N/A | PTMCode2 |
MAP4K2 | MAP3K11 | 25361965 | interaction type | N/A | PTMCode2 |
MAP3K11 | MAP4K2 | 25361965 | interaction type | N/A | PTMCode2 |
MAP4K2 | MAP3K1 | 25361965 | interaction type | N/A | PTMCode2 |
MAP3K1 | MAP4K2 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
HSP90AB1 | MAP4K2 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
RAB8A | MAP4K2 | 14525934 25348397 8643544 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
MAP4K2 | MAP3K11 | 11784851 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
MAP4K2 | TRAF2 | 14525934 25348397 9712898 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
MAP4K2 | MAP3K1 | 11784851 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MAP4K2 | MAP2K4 | 25348397 | N/A | physical interaction | ComPPI |
MAP4K2 | HNRNPA2B1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | XRCC6 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | SERPINA4 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | SNRNP35 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | NACAD | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | DEFB1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | PRDX4 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
MAP4K2 | POT1 | 21044950 24234451 25348397 | physical association | pull down,physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
MAP4K2 | HSP90AA1 | 25348397 | N/A | physical interaction | ComPPI |
MAP4K2 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
MAP4K2 | JUN | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
PKM | MAP4K2 | 25348397 | N/A | protein kinase assay | ComPPI |
MAP4K2 | SCNN1A | 16174865 27898060 | N/A | N/A | OmniPath |
TRAF2 | MAP4K2 | 27898060 9712898 | stimulant | N/A | OmniPath |
MAP4K2 | MAP3K1 | 11784851 27898060 7515885 9712898 | stimulant | N/A | OmniPath |
MAPK8IP1 | MAP4K2 | 10702297 27898060 | inhibition | N/A | OmniPath |
MAP4K2 | PRH1 | 10684652 27898060 | N/A | N/A | OmniPath |
MAP4K2 | SELP | 27898060 7691235 | N/A | N/A | OmniPath |