GENE：MGST2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MGST2 |
| FullNmae | microsomal glutathione S-transferase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7063 |
| EnsembleID | ENSG00000085871 |
| Uniprot | Q99735 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MGST2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MGST2 | GO:0004364,GO:0004364,GO:0004464,GO:0004464,GO:0004602,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006629,GO:0006750,GO:0008047,GO:0010243,GO:0016020,GO:0019370,GO:0019370,GO:0032496,GO:0042802,GO:0042802,GO:0043231,GO:0043295,GO:0046466,GO:0050729,GO:0098869 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MGST2 | hsa:4258 | path:hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05204 | Chemical carcinogenesis - DNA adducts - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| MGST2 | hsa:4258 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | MGST2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MGST2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MGST2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MGST2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MGST2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | MGST2 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000065D58 | MGST2 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000007FBA | MGST2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000039E1E1 | MGST2 | 25416803 25950430 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BCL2L2 | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| JUN | MGST2 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PNKP | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PLN | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| VAMP3 | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CREB3 | MGST2 | 25348397 | N/A | two hybrid bait and prey pooling approach | ComPPI |
| SGCB | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ASIC1 | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SEC22B | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CREB3L1 | MGST2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |