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GENE：NHP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NHP2
FullNmae NHP2 ribonucleoprotein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14377
EnsembleID ENSG00000145912
Uniprot Q9NX24

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NHP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NHP2 GO:0000470,GO:0000781,GO:0003723,GO:0003723,GO:0005515,GO:0005654,GO:0005697,GO:0005697,GO:0005697,GO:0005732,GO:0007004,GO:0007004,GO:0007004,GO:0022625,GO:0031118,GO:0031118,GO:0031120,GO:0031429,GO:0031429,GO:0031429,GO:0034513,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:0090661,GO:1904874

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NHP2 hsa:55651 path:hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOP10 NHP2 10197982 10995457 11283614 17055429 17327415 18566586 19387550 19662498 20027199 20473778 20713526 2191300 21945180 22869732 23551398 26192618 interaction type N/A ACSN
DKC1 NHP2 10197982 10995457 11283614 17055429 17327415 18566586 19387550 19662498 20027199 20473778 20713526 2191300 21945180 22869732 23551398 26192618 interaction type N/A ACSN
NHP2 GAR1 10197982 10995457 11283614 17055429 17327415 18566586 19387550 19662498 20027199 20473778 20713526 2191300 21945180 22869732 23551398 26192618 interaction type N/A ACSN
PTGES3 NHP2 10197982 10995457 11283614 17055429 17327415 18566586 19387550 19662498 20027199 20473778 20713526 2191300 21945180 22869732 23551398 26192618 interaction type N/A ACSN
MKRN1 NHP2 15805468 20473778 26192618 interaction type N/A ACSN
IKBKG NHP2 20098747 23180781 physical association protein array InnateDB
SUZ12 NHP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 NHP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 NHP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NHP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NHP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NHP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000007A060 NHP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D NHP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 NHP2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NHP2 SHQ1 25361965 interaction type N/A PTMCode2
SHQ1 NHP2 25361965 interaction type N/A PTMCode2
NHP2 NOP10 25361965 interaction type N/A PTMCode2
NOP10 NHP2 25361965 interaction type N/A PTMCode2
NHP2 DKC1 25361965 interaction type N/A PTMCode2
DKC1 NHP2 25361965 interaction type N/A PTMCode2
GAR1 NHP2 25361965 interaction type N/A PTMCode2
NHP2 GAR1 25361965 interaction type N/A PTMCode2
NAF1 NHP2 25361965 interaction type N/A PTMCode2
NHP2 NAF1 25361965 interaction type N/A PTMCode2
FBL NHP2 25361965 interaction type N/A PTMCode2
NHP2 FBL 25361965 interaction type N/A PTMCode2
NOP58 NHP2 25361965 interaction type N/A PTMCode2
NHP2 NOP58 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DAXX NHP2 25348397 N/A physical interaction ComPPI
TRAF6 NHP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LMNA NHP2 25348397 N/A physical interaction ComPPI
NOL12 NHP2 25348397 N/A physical interaction ComPPI
BMI1 NHP2 25348397 N/A physical interaction ComPPI
NOP10 NHP2 22085967 24234451 25348397 25416956 25910212 26344197 27898060 30021884 physical association two hybrid,cross-linking study,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct,OmniPath
NHP2 WDR48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NHP2 IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
NHP2 NEDD4 25348397 N/A physical interaction ComPPI
NHP2 CAND1 25348397 N/A physical interaction ComPPI
NHP2 NAF1 12242285 12515383 15798213 17612558 19095616 24234451 25348397 26344197 26496610 27898060 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NHP2 DKC1 19179534 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NHP2 PRNP 25348397 N/A physical interaction ComPPI
NHP2 PRNP 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
NHP2 NOP58 25348397 N/A physical interaction ComPPI
NHP2 GAR1 11433018 21893585 22939629 24234451 25348397 26344197 26496610 27898060 9843512 9848653 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NHP2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
NHP2 MYL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NHP2 JMJD6 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NHP2 LIN28A 25348397 N/A physical interaction ComPPI
NHP2 LIN28B 25348397 N/A physical interaction ComPPI
NHP2 SUZ12 25348397 N/A physical interaction ComPPI
NHP2 RNF2 25348397 N/A physical interaction ComPPI
NHP2 H1-1 25348397 N/A physical interaction ComPPI
NHP2 FBL 25348397 N/A physical interaction ComPPI
NHP2 IFI16 25348397 N/A physical interaction ComPPI
NHP2 NOS1AP 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NHP2 XPO1 25348397 N/A physical interaction ComPPI
NHP2 FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NHP2 NOLC1 25348397 N/A physical interaction ComPPI
NHP2 TCOF1 25348397 N/A physical interaction ComPPI
NHP2 ZNF131 25348397 N/A physical interaction ComPPI
NHP2 BCHE 25348397 N/A physical interaction ComPPI
NHP2 UTP23 25348397 N/A physical interaction ComPPI
NHP2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NHP2 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NHP2 HMBOX1 23685356 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NHP2 MNDA 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
NHP2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF5B NHP2 25348397 N/A physical interaction ComPPI
NEDD4L NHP2 25348397 N/A physical interaction ComPPI
LYAR NHP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NHP2 TSH 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IKBKG NHP2 20098747 27898060 N/A N/A OmniPath

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