Gene Information gene info

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GENE：ORC3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORC3
FullNmae origin recognition complex subunit 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8489
EnsembleID ENSG00000135336
Uniprot Q9UBD5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORC3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORC3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ORC3 GO:0000781,GO:0000785,GO:0000808,GO:0003688,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005656,GO:0005664,GO:0005664,GO:0005664,GO:0006260,GO:0006270,GO:0006270,GO:0006275,GO:0014009,GO:0016604,GO:0031261,GO:0061351

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ORC3 hsa:23595 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDT1 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM2 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC1 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 MCM6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC3 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 ORC3 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 ORC3 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 ORC3 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 ORC3 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 ORC3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 ORC3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 ORC3 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 ORC3 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP ORC3 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR ORC3 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 ORC3 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN ORC3 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN ORC3 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ZBP1 ORC3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
MCMBP ORC3 23180781 24299456 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ORC3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 ORC3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 ORC3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ORC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
ORC1 ORC3 14525934 15232106 16549788 17716973 22398447 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SNW1 ORC3 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L ORC3 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM5 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,in vitro ComPPI,HPRD,IntAct
ORC6 ORC3 11323433 14525934 15232106 17716973 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,protein array,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
STN1 ORC3 25348397 N/A physical interaction ComPPI
H4C1 ORC3 25348397 N/A physical interaction ComPPI
TACC3 ORC3 25348397 N/A physical interaction ComPPI
VAPA ORC3 25348397 N/A physical interaction ComPPI
ORC4 ORC3 11323433 11395502 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MCM10 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
NTRK1 ORC3 25348397 N/A physical interaction ComPPI
XRCC5 ORC3 25348397 N/A physical interaction ComPPI
KIFAP3 ORC3 25348397 N/A physical interaction ComPPI
CDC6 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
PLK1 ORC3 25348397 N/A physical interaction ComPPI
XRCC6 ORC3 25348397 N/A physical interaction ComPPI
ORC2 ORC3 10402192 11323433 11395502 14525934 16549788 17716973 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CCNE2 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
KLC1 ORC3 25348397 N/A physical interaction ComPPI
CBX5 ORC3 20689044 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
H3-4 ORC3 25348397 N/A physical interaction ComPPI
MDC1 ORC3 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
CDC45 ORC3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
FOXE1 ORC3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ILF2 ORC3 20808282 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
CDK4 ORC3 14525934 15232106 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ORC3 ORC5 11395502 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC3 DBF4 12441400 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ORC3 MCM7 12614612 14525934 15232106 24234451 25348397 N/A two hybrid,protein array,physical interaction,two hybrid ComPPI,HPRD,IntAct
ORC3 MCM4 25348397 N/A physical interaction ComPPI
ORC3 BRCA1 17525332 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC3 TERF2 25348397 N/A physical interaction ComPPI
ORC3 ZBP1 25348397 N/A physical interaction ComPPI
ORC3 APP 25348397 N/A physical interaction ComPPI
ORC3 LRWD1 25348397 N/A physical interaction ComPPI
ORC3 SNX11 25348397 N/A physical interaction ComPPI
ORC3 COA8 25348397 N/A physical interaction ComPPI
ORC3 NOP9 25348397 N/A physical interaction ComPPI
ORC3 QSOX2 25348397 N/A physical interaction ComPPI
ORC3 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC3 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC3 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC3 RPGR 25348397 N/A physical interaction ComPPI
ORC3 MCMBP 24234451 24299456 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ORC3 CAT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ORC3 ORC3 14525934 15232106 N/A experimental interaction detection HPRD
ZBP1 ORC3 21903422 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BD337 ORC3 27087310 direct interaction,inhibition N/A NPInter

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