Gene Information gene info

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GENE：ORC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORC4
FullNmae origin recognition complex subunit 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8490
EnsembleID ENSG00000115947
Uniprot O43929

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORC4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORC4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ORC4 GO:0000166,GO:0000781,GO:0000781,GO:0000808,GO:0003688,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005664,GO:0005664,GO:0005664,GO:0005730,GO:0005829,GO:0006270,GO:0006270,GO:0006270,GO:0016887,GO:0040038,GO:0051258

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ORC4 hsa:5000 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDT1 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC4 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 MCM2 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 MCM6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 ORC4 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 ORC4 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 ORC4 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 ORC4 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 ORC4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 ORC4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 ORC4 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 ORC4 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP ORC4 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR ORC4 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 ORC4 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN ORC4 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN ORC4 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 ORC4 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ORC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ORC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ORC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 ORC4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000028DE3F ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000475586 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F6E49 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000036B845 ORC4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A ORC4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 ORC4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000052EA98 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000045B99E ORC4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F0F49 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040EE1D ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041CB9C ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000171CD1 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004A9320 ORC4 20371350 21572407 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A611 ORC4 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 ORC4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD ORC4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 ORC4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D ORC4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 ORC4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002198F3 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C ORC4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 ORC4 21572407 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049FAE8 ORC4 21572407 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 ORC4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 ORC4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 ORC4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 ORC4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000939AF ORC4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 ORC4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B59A2 ORC4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 ORC4 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ORC1 ORC4 16549788 17716973 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,pull down,physical interaction ComPPI,IntAct
SNW1 ORC4 25348397 N/A physical interaction ComPPI
CDC5L ORC4 25348397 N/A physical interaction ComPPI
TSNAX ORC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCND1 ORC4 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
KPNA1 ORC4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCM6 ORC4 25348397 N/A physical interaction ComPPI
MCM2 ORC4 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC6 ORC4 14525934 15232106 18234858 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro,bimolecular fluorescence complementation ComPPI,HPRD,IntAct
H4C1 ORC4 25348397 N/A physical interaction ComPPI
CTBP1 ORC4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC4 CDKN2A 15232106 24234451 25348397 N/A protein array,physical interaction,in vitro ComPPI,IntAct
ORC4 ORC2 11323433 14525934 15232106 16549788 17716973 24234451 25348397 9353276 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC4 MCM3 15232106 24234451 25348397 N/A two hybrid,protein array,physical interaction ComPPI,IntAct
ORC4 ORC3 11323433 11395502 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ORC4 MCM10 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC4 ORC5 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC4 MCM7 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC4 MCM4 25348397 N/A physical interaction ComPPI
ORC4 RPA2 25348397 N/A physical interaction ComPPI
ORC4 DBF4 25348397 N/A physical interaction ComPPI
ORC4 CCL2 25348397 N/A physical interaction ComPPI
ORC4 XRCC5 25348397 N/A physical interaction ComPPI
ORC4 XRCC6 25348397 N/A physical interaction ComPPI
ORC4 APP 25348397 N/A physical interaction ComPPI
ORC4 CDKN2A 25348397 N/A physical interaction ComPPI
ORC4 FBXO6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC4 MLH1 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
ORC4 FBXL5 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
ORC4 FBXO25 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC4 MTUS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC4 TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ORC4 RRM2B 24234451 25348397 25416956 physical association physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ORC4 H3-4 25348397 N/A physical interaction ComPPI
ORC4 LACC1 25348397 N/A physical interaction ComPPI
ORC4 PABPC1 25348397 N/A physical interaction ComPPI
ORC4 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC4 KLC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC4 LRWD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC4 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC4 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC4 MTMR3 25348397 N/A physical interaction ComPPI
ORC4 CD93 25348397 N/A physical interaction ComPPI
ORC4 LAMP1 25348397 N/A physical interaction ComPPI
ORC4 DLK1 25348397 N/A physical interaction ComPPI
ORC4 IL1R2 25348397 N/A physical interaction ComPPI
ORC4 TXNDC15 25348397 N/A physical interaction ComPPI
ORC4 P2RX4 25348397 N/A physical interaction ComPPI
ORC4 RDH5 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
ORC4 TUBA1A 24234451 25348397 27291054 association pull down ComPPI,IntAct
ORC4 CAT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FBXL8 ORC4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSCB ORC4 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B32FA ORC4 27087310 direct interaction,inhibition N/A NPInter

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