Gene Information gene info

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GENE：ORC5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORC5
FullNmae origin recognition complex subunit 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8491
EnsembleID ENSG00000164815
Uniprot O43913

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORC5 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORC5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ORC5 GO:0000166,GO:0000781,GO:0000785,GO:0000808,GO:0003674,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005664,GO:0005664,GO:0005664,GO:0005664,GO:0005829,GO:0006260,GO:0006270,GO:0006270,GO:0006275

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ORC5 hsa:5001 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDT1 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM2 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM3 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM4 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
MCM7 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC2 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC4 ORC5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 CDC45 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 CDC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 MCM5 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 MCM6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 ORC1 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 ORC3 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
ORC5 ORC6 10882098 12185086 12909626 15279786 17102137 17116885 17296725 17303408 17582221 17608804 17660363 17887956 18451105 18590585 19158510 19793801 21406556 21527023 26192618 7575488 interaction type N/A ACSN
CDK2 ORC5 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
DBF4 ORC5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
RPA1 ORC5 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA2 ORC5 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
RPA3 ORC5 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258 26192618 interaction type N/A ACSN
HUS1 ORC5 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 ORC5 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 ORC5 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
CDK1 ORC5 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 26192618 7575488 interaction type N/A ACSN
ATRIP ORC5 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
ATR ORC5 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CHEK1 ORC5 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
CLSPN ORC5 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN
TIPIN ORC5 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 26192618 8943031 9524127 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 ORC5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ORC5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ORC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 ORC5 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001A405B ORC5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 ORC5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007A060 ORC5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B ORC5 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KRT18 ORC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC1 ORC5 14525934 15232106 16549788 17716973 22398447 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
SNW1 ORC5 25348397 N/A physical interaction ComPPI
CDC5L ORC5 14525934 15232106 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MCM5 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
MCM2 ORC5 12614612 14525934 15232106 24234451 25348397 N/A two hybrid,experimental interaction detection,protein array,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
DPEP1 ORC5 25348397 N/A physical interaction ComPPI
ORC6 ORC5 18234858 24234451 25348397 N/A physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
H4C1 ORC5 25348397 N/A physical interaction ComPPI
NFATC1 ORC5 25348397 N/A physical interaction ComPPI
JUN ORC5 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
NONO ORC5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ORC4 ORC5 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDKN2A ORC5 15232106 24234451 25348397 N/A protein array ComPPI,IntAct
CDC6 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
PPP1CA ORC5 19389623 24234451 25348397 N/A pull down ComPPI,IntAct
RPA2 ORC5 25348397 N/A physical interaction ComPPI
ORC2 ORC5 11323433 14525934 15232106 16549788 17716973 24234451 25348397 26496610 9765232 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
H3-4 ORC5 25348397 N/A physical interaction ComPPI
EGFR ORC5 25348397 N/A physical interaction ComPPI
CD70 ORC5 25348397 N/A physical interaction ComPPI
UBQLN4 ORC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TAX1BP1 ORC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LAMP2 ORC5 25348397 N/A physical interaction ComPPI
APLNR ORC5 25348397 N/A physical interaction ComPPI
VIPR2 ORC5 25348397 N/A physical interaction ComPPI
CDC45 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDC7 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
TRIM25 ORC5 25348397 N/A physical interaction ComPPI
MCM3 ORC5 15232106 24234451 25348397 N/A two hybrid,protein array,physical interaction ComPPI,IntAct
ORC3 ORC5 11395502 14525934 15232106 17716973 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
ORC5 MCM7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ORC5 MCM4 25348397 N/A physical interaction ComPPI
ORC5 DBF4 25348397 N/A physical interaction ComPPI
ORC5 LRWD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ORC5 DGKA 25348397 N/A physical interaction ComPPI
ORC5 LAMB2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 CALCOCO2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 STAB1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 TXNDC11 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 SIPA1L2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 DMRTA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ORC5 NIF3L1 25348397 N/A physical interaction ComPPI
ORC5 TMEM171 25348397 N/A physical interaction ComPPI
ORC5 LYPD3 25348397 N/A physical interaction ComPPI
ORC5 SCN2B 25348397 N/A physical interaction ComPPI
ORC5 FAM234B 25348397 N/A physical interaction ComPPI
ORC5 C3AR1 25348397 N/A physical interaction ComPPI
ORC5 IL13RA2 25348397 N/A physical interaction ComPPI
ORC5 SU(VAR)205 25348397 N/A physical interaction ComPPI
ORC5 ORC5 15232106 24234451 N/A protein array IntAct

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