GENE：PWP2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PWP2 |
| FullNmae | PWP2 small subunit processome component |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9711 |
| EnsembleID | ENSG00000241945 |
| Uniprot | Q15269 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PWP2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PWP2 | GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0032040,GO:0032040,GO:0034388,GO:0042274 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PWP2 | hsa:5822 | path:hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | PWP2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PWP2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PWP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PWP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PWP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PWP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PWP2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PWP2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000EED18 | PWP2 | 21566225 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00000AD002 | PWP2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000148B91 | PWP2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IMP4 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | IMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| PNO1 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | PNO1 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | UTP15 | 25361965 | interaction type | N/A | PTMCode2 |
| UTP15 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | DCAF13 | 25361965 | interaction type | N/A | PTMCode2 |
| DCAF13 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | IMP3 | 25361965 | interaction type | N/A | PTMCode2 |
| IMP3 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | NOC4L | 25361965 | interaction type | N/A | PTMCode2 |
| NOC4L | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | DKC1 | 25361965 | interaction type | N/A | PTMCode2 |
| DKC1 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | BMS1 | 25361965 | interaction type | N/A | PTMCode2 |
| BMS1 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | NOL10 | 25361965 | interaction type | N/A | PTMCode2 |
| NOL10 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | RCL1 | 25361965 | interaction type | N/A | PTMCode2 |
| RCL1 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| MPHOSPH10 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | MPHOSPH10 | 25361965 | interaction type | N/A | PTMCode2 |
| NAT10 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | NAT10 | 25361965 | interaction type | N/A | PTMCode2 |
| KRR1 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | KRR1 | 25361965 | interaction type | N/A | PTMCode2 |
| FBL | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | FBL | 25361965 | interaction type | N/A | PTMCode2 |
| RBM19 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | RBM19 | 25361965 | interaction type | N/A | PTMCode2 |
| NOP58 | PWP2 | 25361965 | interaction type | N/A | PTMCode2 |
| PWP2 | NOP58 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BYSL | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| CEP19 | PWP2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| IPO13 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| TBL3 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| FGF3 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| JUN | PWP2 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RBM4 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| TOM1L1 | PWP2 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| BAG6 | PWP2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CD247 | PWP2 | 24234451 24502978 25348397 | association | pull down | ComPPI,IntAct |
| XPO1 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| DNAJC7 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6 | PWP2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| CUL1 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| MMS19 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| EED | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| MECP2 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL7 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| FOXA1 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| GYPB | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| HECW2 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| CNTRL | PWP2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| IFI16 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| TARDBP | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP1B | PWP2 | 20926688 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MPHOSPH10 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| IMP3 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| HDGF | PWP2 | 21907836 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| FBL | PWP2 | 24234451 25348397 29568061 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| FGF8 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| RRP9 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT7 | PWP2 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | USP36 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PWP2 | WDR36 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | OBSL1 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | DDX18 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | WDR3 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | B9D2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| PWP2 | ZNF746 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | PACC1 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | ZNF71 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | BBS7 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | ZNF692 | 25348397 | N/A | physical interaction | ComPPI |
| PWP2 | RNF169 | 21252943 24234451 25348397 | association | pull down | ComPPI,IntAct |
| DDX41 | PWP2 | 24234451 25348397 25920683 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HSCB | PWP2 | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PWP2 | UTP18 | 24234451 30021884 | physical association | cross-linking study | IntAct |