Gene Information gene info

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GENE：PYCR3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PYCR3
FullNmae pyrroline-5-carboxylate reductase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25846
EnsembleID ENSG00000104524
Uniprot Q53H96

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PYCR3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PYCR3 GO:0004735,GO:0004735,GO:0005515,GO:0005829,GO:0005829,GO:0045171,GO:0055129,GO:0055129,GO:0055129,GO:0072686

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PYCR3 hsa:65263 path:hsa00330 Arginine and proline metabolism - Homo sapiens (human)
PYCR3 hsa:65263 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PYCR3 hsa:65263 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PYCR3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PYCR3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PYCR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PYCR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PYCR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PYCR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PYCR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 PYCR3 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000057A7C PYCR3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000054DF42 PYCR3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000086A4D PYCR3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 PYCR3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PSMB2 PYCR3 25348397 N/A physical interaction ComPPI
CUL3 PYCR3 25348397 N/A physical interaction ComPPI
PSMA6 PYCR3 25348397 N/A physical interaction ComPPI
KSR2 PYCR3 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
SDCBP PYCR3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LBP PYCR3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAG4 PYCR3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB5 PYCR3 25348397 N/A physical interaction ComPPI
CDKN2B PYCR3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB1 PYCR3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB3 PYCR3 25348397 N/A physical interaction ComPPI
PSMA7 PYCR3 25348397 N/A physical interaction ComPPI
PSMA4 PYCR3 25348397 N/A physical interaction ComPPI
UIMC1 PYCR3 25348397 N/A physical interaction ComPPI
DGCR8 PYCR3 25348397 N/A physical interaction ComPPI
ULK2 PYCR3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FUS PYCR3 25348397 N/A physical interaction ComPPI
PYCR3 BABAM1 25348397 N/A physical interaction ComPPI
PYCR3 PRMT6 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PYCR3 PYCR1 25348397 N/A physical interaction ComPPI
PYCR3 PYCR2 25348397 N/A physical interaction ComPPI
PYCR3 GPD1L 25348397 N/A physical interaction ComPPI
PYCR3 TP53 22653443 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PYCR3 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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