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GENE：CAD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAD
FullNmae carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1424
EnsembleID ENSG00000084774
Uniprot P27708

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAD necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CAD GO:0001889,GO:0004070,GO:0004070,GO:0004088,GO:0004088,GO:0004151,GO:0004151,GO:0004151,GO:0004672,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006207,GO:0006207,GO:0006207,GO:0006225,GO:0006228,GO:0006541,GO:0006541,GO:0006805,GO:0007507,GO:0007565,GO:0007595,GO:0008270,GO:0014075,GO:0016020,GO:0016363,GO:0018107,GO:0019240,GO:0019899,GO:0031000,GO:0031100,GO:0032868,GO:0032991,GO:0033574,GO:0042594,GO:0042802,GO:0042802,GO:0042995,GO:0043025,GO:0043195,GO:0044205,GO:0044205,GO:0046777,GO:0051414,GO:0070062,GO:0070335,GO:0071364

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAD hsa:790 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
CAD hsa:790 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
CAD hsa:790 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CAD hsa:790 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RICTOR CAD 17461779 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD2 CAD 18729074 23180781 physical association tandem affinity purification InnateDB
CAD NOD2 22387394 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TRH CAD 17207870 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
AR CAD 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 CAD 12746293 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ETS1 CAD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CAD 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 CAD 12746293 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 CAD 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF CAD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CAD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CAD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CAD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CAD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 CAD 14559996 trascriptional regulation,stimulation inferred by curator TFlink
MYC CAD 10931841 17706770 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 CAD 14559996 trascriptional regulation,stimulation inferred by curator TFlink
USF1 CAD N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 CAD N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CAD 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 CAD 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AD002 CAD 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS000017EA6A CAD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 CAD 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS00001597DC CAD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C11BC CAD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 CAD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001938D9 CAD 23592263 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000075BEA7 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000157F5 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002EF20A CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 CAD 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000486E0B CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A052 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CCD18 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000045147B CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA CAD 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA CAD 22135298 phosphorylation N/A PhosphoSite
MAPK3 CAD 22135298 phosphorylation N/A PhosphoSite
MAPK1 CAD 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPS6KB1 CAD 22135298 phosphorylation N/A PhosphoSite
CAD MAPK1 25361965 interaction type N/A PTMCode2
CAD CASP3 25361965 interaction type N/A PTMCode2
CASP3 CAD 25361965 interaction type N/A PTMCode2
CAD SHC1 25361965 interaction type N/A PTMCode2
SHC1 CAD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 CAD 25348397 N/A physical interaction ComPPI
PSMC3 CAD 25348397 N/A physical interaction ComPPI
PSMC6 CAD 25348397 N/A physical interaction ComPPI
ACTG1 CAD 25348397 N/A physical interaction ComPPI
GABARAPL2 CAD 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTB CAD 25348397 N/A physical interaction ComPPI
YWHAG CAD 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAD21 CAD 25348397 N/A physical interaction ComPPI
KEAP1 CAD 25348397 N/A physical interaction ComPPI
MCM2 CAD 25348397 N/A physical interaction ComPPI
MAP1LC3B CAD 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CBL CAD 25348397 N/A physical interaction ComPPI
MAPK1 CAD 12438317 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NFATC1 CAD 25348397 N/A physical interaction ComPPI
SHC1 CAD 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CASP3 CAD 11854437 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB2 CAD 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
JUN CAD 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 CAD 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACA CAD 11986331 14525934 25348397 4092695 N/A experimental interaction detection,in vitro ComPPI,HPRD
CUL3 CAD 25348397 N/A physical interaction ComPPI
YWHAZ CAD 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
TUBG1 CAD 25348397 N/A physical interaction ComPPI
NTRK1 CAD 25348397 N/A physical interaction ComPPI
RUVBL1 CAD 25348397 N/A physical interaction ComPPI
COPB1 CAD 25348397 N/A physical interaction ComPPI
ILK CAD 23455922 24234451 25348397 25852190 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
HSPA5 CAD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA4 CAD 25348397 N/A physical interaction ComPPI
PPP1CA CAD 14525934 25348397 4092695 N/A experimental interaction detection,in vitro ComPPI,HPRD
TNFRSF1A CAD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJA3 CAD 25348397 N/A physical interaction ComPPI
EEF1A1 CAD 25348397 N/A physical interaction ComPPI
TUBA4A CAD 25348397 N/A physical interaction ComPPI
UBR5 CAD 25348397 N/A physical interaction ComPPI
CAD PPP2CA 14525934 25348397 4092695 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAD HDAC5 25348397 N/A physical interaction ComPPI
CAD NCOA2 25348397 N/A physical interaction ComPPI
CAD SIRT7 25348397 N/A physical interaction ComPPI
CAD ERG 25348397 N/A physical interaction ComPPI
CAD FBXO25 25348397 N/A physical interaction ComPPI
CAD CDK2 25348397 N/A physical interaction ComPPI
CAD RUVBL2 25348397 N/A physical interaction ComPPI
CAD TUBB4B 25348397 N/A physical interaction ComPPI
CAD PSMD1 25348397 N/A physical interaction ComPPI
CAD XPO1 25348397 N/A physical interaction ComPPI
CAD TUBB2A 25348397 N/A physical interaction ComPPI
CAD SMARCC2 25348397 N/A physical interaction ComPPI
CAD RPS3 25348397 N/A physical interaction ComPPI
CAD PSMC2 25348397 N/A physical interaction ComPPI
CAD VARS1 25348397 N/A physical interaction ComPPI
CAD HTRA2 25348397 N/A physical interaction ComPPI
CAD TP63 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CAD NOS2 25348397 N/A physical interaction ComPPI
CAD ITGA4 25348397 N/A physical interaction ComPPI
CAD HDAC11 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD HDAC6 25348397 N/A physical interaction ComPPI
CAD FBXO6 25348397 N/A physical interaction ComPPI
CAD NEDD4 25348397 N/A physical interaction ComPPI
CAD WWOX 25348397 N/A physical interaction ComPPI
CAD LGR4 25348397 N/A physical interaction ComPPI
CAD STAU1 25348397 N/A physical interaction ComPPI
CAD SPRTN 25348397 N/A physical interaction ComPPI
CAD TP53 25348397 N/A physical interaction ComPPI
CAD CUL7 25348397 N/A physical interaction ComPPI
CAD OBSL1 25348397 N/A physical interaction ComPPI
CAD CCDC8 25348397 N/A physical interaction ComPPI
CAD SUMO2 25348397 N/A physical interaction ComPPI
CAD RPS6KB2 25348397 N/A physical interaction ComPPI
CAD ACTR1A 25348397 N/A physical interaction ComPPI
CAD ACSS2 25348397 N/A physical interaction ComPPI
CAD ATP1A1 25348397 N/A physical interaction ComPPI
CAD DARS1 25348397 N/A physical interaction ComPPI
CAD DNAJA2 25348397 N/A physical interaction ComPPI
CAD PC 25348397 N/A physical interaction ComPPI
CAD SARS1 25348397 N/A physical interaction ComPPI
CAD CCT3 25348397 N/A physical interaction ComPPI
CAD CCT4 25348397 N/A physical interaction ComPPI
CAD CCT6A 25348397 N/A physical interaction ComPPI
CAD CCT8 25348397 N/A physical interaction ComPPI
CAD CLTC 25348397 N/A physical interaction ComPPI
CAD DDX3X 25348397 N/A physical interaction ComPPI
CAD DNAJA1 25348397 N/A physical interaction ComPPI
CAD DNAJA4 25348397 N/A physical interaction ComPPI
CAD EEF1A1P5 25348397 N/A physical interaction ComPPI
CAD EIF2B1 25348397 N/A physical interaction ComPPI
CAD EIF2S1 25348397 N/A physical interaction ComPPI
CAD EPRS1 25348397 N/A physical interaction ComPPI
CAD GFPT1 25348397 N/A physical interaction ComPPI
CAD IARS1 25348397 N/A physical interaction ComPPI
CAD IDH3A 25348397 N/A physical interaction ComPPI
CAD IPO4 25348397 N/A physical interaction ComPPI
CAD MCM7 25348397 N/A physical interaction ComPPI
CAD PSMC4 25348397 N/A physical interaction ComPPI
CAD PSMC5 25348397 N/A physical interaction ComPPI
CAD PSMD12 25348397 N/A physical interaction ComPPI
CAD PSMD2 25348397 N/A physical interaction ComPPI
CAD PSMD4 25348397 N/A physical interaction ComPPI
CAD SLC25A3 25348397 N/A physical interaction ComPPI
CAD UQCRC2 25348397 N/A physical interaction ComPPI
CAD YME1L1 25348397 N/A physical interaction ComPPI
CAD AHI1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAD MKS1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAD POC1B 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAD LGALS3BP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD MAD2L1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD DNAJC7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD SEC16A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD TRIM29 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD SKI 25348397 N/A physical interaction ComPPI
CAD MEX3C 22863774 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CAD OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD POU5F1 25348397 N/A physical interaction ComPPI
CAD RC3H1 25348397 N/A physical interaction ComPPI
CAD NFATC2 25348397 N/A physical interaction ComPPI
CAD DERL1 25348397 N/A physical interaction ComPPI
CAD ZNF746 25348397 N/A physical interaction ComPPI
CAD MTMR11 25348397 N/A physical interaction ComPPI
CAD CYLD 25348397 N/A physical interaction ComPPI
CAD VHL 25348397 N/A physical interaction ComPPI
CAD FASN 25348397 N/A physical interaction ComPPI
CAD BRCA1 25348397 N/A physical interaction ComPPI
CAD YAP1 25348397 N/A physical interaction ComPPI
CAD TES 25348397 N/A physical interaction ComPPI
CAD CFTR 25348397 N/A physical interaction ComPPI
CAD TRAPPC3 25348397 N/A physical interaction,tandem affinity purification ComPPI
CAD NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD NFKB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RELA 25348397 N/A tandem affinity purification ComPPI
CAD RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RIPK1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD TAB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD MAP3K7 25348397 N/A tandem affinity purification ComPPI
CAD TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD TRADD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD TRAF2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RPS9 17461779 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CAD PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CAD VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
CAD HTR7 19486527 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CAD RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD ESR1 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
CAD ESR2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
CAD TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
CAD TUBA1A 24234451 25348397 27291054 29568061 association pull down ComPPI,IntAct
CAD PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
CAD PPP5C 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
CAD DUSP16 24234451 25348397 28330616 association pull down ComPPI,IntAct
CAD RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAPK6 CAD 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP3K14 CAD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PTPN23 CAD 24234451 25348397 28330616 association pull down ComPPI,IntAct
HSCB CAD 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
LRFN4 CAD 22677168 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CAD CAD 11986331 12438317 14523024 14525934 24234451 24332717 N/A cosedimentation in solution,experimental interaction detection,x-ray crystallography HPRD,IntAct
METTL3 CAD 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SMARCB1 CAD 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
CAD MYO3A 12927282 27898060 N/A N/A OmniPath
PRKACA CAD 11986331 17206380 17322306 18669648 18691976 18707149 18767875 19651622 19664994 19664995 20068231 27898060 4092695 inhibition N/A OmniPath
CAD NOD2 22387394 27898060 N/A N/A OmniPath
RICTOR CAD 17461779 27898060 N/A N/A OmniPath
MAPK3 CAD 14991569 15890648 17206380 25472841 27898060 stimulant N/A OmniPath
PPP1CB CAD 27898060 4092695 N/A N/A OmniPath
PPP1CA CAD 27898060 4092695 N/A N/A OmniPath
MAPK1 CAD 12438317 14991569 15890648 17206380 17485345 27898060 stimulant N/A OmniPath
PPP2CA CAD 27898060 4092695 N/A N/A OmniPath
RPS6KB1 CAD 1359877 23429703 27898060 stimulant N/A OmniPath
PPP1CC CAD 27898060 4092695 N/A N/A OmniPath
PPP2CB CAD 27898060 4092695 N/A N/A OmniPath

Visualization










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