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GENE：CASP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP3
FullNmae caspase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1504
EnsembleID ENSG00000164305
Uniprot P42574

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP3 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP3 necroptosis 38335615 The results showed that SS-induced mitochondrial reactive oxygen species (mtROS) accumulation activated the BAX/Bcl-2/caspase 3 pathway to trigger apoptosis and RIPK1/RIPK3/p-MLKL to trigger necroptosis. retulator signature
CASP3 mitotic_cd 21151026 Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death retulator signature
CASP3 autophagy 34729793 In addition, the level of caspase-3, as an autophagy inhibitory protein, did not increase significantly in the cytoplasm of Sertoli cells as opposed to whole testicular tissue, indicating that autophagy is active after testicular torsion in these cells. retulator signature
CASP3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP3 apoptosis 34873207 Paclitaxel induced intrinsic apoptosis by activating caspase-3, caspase-9 and PARP. retulator signature
CASP3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP3 GO:0001554,GO:0001666,GO:0001782,GO:0001818,GO:0002020,GO:0004190,GO:0004197,GO:0004861,GO:0005123,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006508,GO:0006915,GO:0006915,GO:0006915,GO:0006974,GO:0007413,GO:0007507,GO:0007605,GO:0007611,GO:0008233,GO:0008627,GO:0009410,GO:0009411,GO:0009611,GO:0009749,GO:0010165,GO:0016005,GO:0016241,GO:0016485,GO:0021766,GO:0030163,GO:0030182,GO:0030216,GO:0030218,GO:0030218,GO:0030218,GO:0030220,GO:0030889,GO:0031264,GO:0031647,GO:0032025,GO:0032355,GO:0032496,GO:0034349,GO:0034612,GO:0035094,GO:0042542,GO:0043025,GO:0043029,GO:0043065,GO:0043200,GO:0043525,GO:0044346,GO:0044877,GO:0045165,GO:0045786,GO:0046007,GO:0048011,GO:0051146,GO:0051384,GO:0051402,GO:0051604,GO:0061713,GO:0070269,GO:0071887,GO:0072734,GO:0097153,GO:0097153,GO:0097153,GO:0097190,GO:0097193,GO:0097194,GO:0097194,GO:0097199,GO:0097199,GO:0097200,GO:0097200,GO:0140639,GO:1902004,GO:1904019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP3 hsa:836 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
CASP3 hsa:836 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CASP3 hsa:836 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
CASP3 hsa:836 path:hsa04148 Efferocytosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
CASP3 hsa:836 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CASP3 hsa:836 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
CASP3 hsa:836 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
CASP3 hsa:836 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CASP3 hsa:836 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
CASP3 hsa:836 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
CASP3 hsa:836 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa05012 Parkinson disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05016 Huntington disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa05020 Prion disease - Homo sapiens (human)
CASP3 hsa:836 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CASP3 hsa:836 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05132 Salmonella infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05133 Pertussis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05134 Legionellosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05146 Amoebiasis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05152 Tuberculosis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05160 Hepatitis C - Homo sapiens (human)
CASP3 hsa:836 path:hsa05161 Hepatitis B - Homo sapiens (human)
CASP3 hsa:836 path:hsa05162 Measles - Homo sapiens (human)
CASP3 hsa:836 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05164 Influenza A - Homo sapiens (human)
CASP3 hsa:836 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CASP3 hsa:836 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CASP3 hsa:836 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
CASP3 hsa:836 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
CASP3 hsa:836 path:hsa05210 Colorectal cancer - Homo sapiens (human)
CASP3 hsa:836 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
CASP3 hsa:836 path:hsa05416 Viral myocarditis - Homo sapiens (human)
CASP3 hsa:836 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CASP3 XIAP 11157976 11230124 11257232 11359776 11447297 11927604 12181739 12529384 12874265 15014070 15200957 17069460 19559631 23180781 9230442 9525868 9545235 ubiquitination reaction,protein cleavage,physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down,x-ray crystallography,ubiquitination reaction,protease assay InnateDB
CASP3 UBE2D2 11447297 23180781 ubiquitination reaction ubiquitination reaction InnateDB
CASP9 CASP3 12181739 23180781 physical association gst pull down InnateDB
XIAP CASP3 12181739 23180781 physical association gst pull down InnateDB
CASP3 CASP9 12181739 12620238 17437405 23180781 8900201 cleavage reaction,protein cleavage,physical association affinity chromatography technology,protease assay InnateDB
CASP3 APAF1 12874265 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP2CA CASP3 15569672 23180781 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,in gel phosphatase assay InnateDB
CASP3 MAPK14 14970175 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
CDH1 CASP3 11076937 23180781 cleavage reaction protease assay InnateDB
CASP8 CASP3 23180781 9208847 physical association anti tag coimmunoprecipitation InnateDB
CASP3 BIRC5 16540654 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKBIA CASP3 23180781 9367996 cleavage reaction cleavage reaction InnateDB
CASP3 PAK2 23180781 9171063 cleavage reaction protease assay InnateDB
CASP3 MAPK8 12821118 23180781 cleavage reaction cleavage reaction InnateDB
CASP3 MAPK9 12821118 23180781 cleavage reaction cleavage reaction InnateDB
COPS6 CASP3 17337451 23180781 cleavage reaction cleavage reaction InnateDB
EGFR CASP3 11226410 23180781 cleavage reaction protease assay InnateDB
CASP3 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
CASP3 PARP1 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
CASP3 IL18 23180781 9334240 cleavage reaction protease assay InnateDB
CASP3 CASP8 15014070 17179148 18458084 23180781 cleavage reaction,protein cleavage protease assay InnateDB
HDAC7 CASP3 18458084 23180781 cleavage reaction protease assay InnateDB
APP CASP3 10409650 23180781 cleavage reaction protease assay InnateDB
CASP3 RNF7 17217622 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBX1 CASP3 17217622 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 FBXW11 17217622 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 BTRC 17217622 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 BIRC3 17069460 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 BIRC2 17069460 23180781 physical association anti tag coimmunoprecipitation InnateDB
AFP CASP3 19267404 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
CASP3 AKT3 17544405 23180781 cleavage reaction enzymatic study,protease assay InnateDB
CASP3 AKT2 17544405 23180781 cleavage reaction enzymatic study,protease assay InnateDB
AKT1 CASP3 17544405 23180781 cleavage reaction enzymatic study,protease assay InnateDB
GZMB CASP3 11696597 12745270 15569669 16415351 16495481 17179148 17283187 19103589 23180781 8700869 8755496 protein cleavage protease assay InnateDB
CASP3 DFFA 11406587 23180781 protein cleavage protease assay InnateDB
CASP3 CASP10 23180781 8755496 protein cleavage protease assay InnateDB
CASP6 CASP3 23180781 8900201 protein cleavage protease assay InnateDB
CASP3 CD247 12208735 23180781 protein cleavage protease assay InnateDB
CASP3 CASP1 23180781 8700869 protein cleavage protease assay InnateDB
CASP3 MCL1 15014070 23180781 protein cleavage protease assay InnateDB
GZMH CASP3 17765974 23180781 protein cleavage protease assay InnateDB
GZMM CASP3 16818775 23180781 protein cleavage protease assay InnateDB
CASP3 MAVS 20032188 23180781 cleavage reaction protease assay InnateDB
ELAVL1 CASP3 15257295 23180781 physical association anti tag coimmunoprecipitation InnateDB
HNRNPD CASP3 15257295 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG4D CASP3 19549685 23180781 cleavage reaction protease assay InnateDB
CASP3 ARHGDIA 19559631 23180781 protein cleavage protease assay InnateDB
PTGES3 CASP3 19559631 23180781 protein cleavage protease assay InnateDB
CASP3 IL33 19559631 23180781 protein cleavage protease assay InnateDB
CDK2 CASP3 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 CASP3 14585074 15231831 15657060 26467481 cleavage reaction,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR CASP3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CASP3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 CASP3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ING1 CASP3 15662138 trascriptional regulation,stimulation inferred by curator TFlink
ING4 CASP3 19895734 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CASP3 20056115 trascriptional regulation,stimulation inferred by curator TFlink
PHF10 CASP3 20530714 trascriptional regulation,stimulation inferred by curator TFlink
PML CASP3 16253165 trascriptional regulation,stimulation inferred by curator TFlink
RELA CASP3 20056115 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 CASP3 15930301 19290488 trascriptional regulation,stimulation inferred by curator TFlink
SIM2 CASP3 21729534 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CASP3 11773055 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CASP3 11773055 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CASP3 21859835 trascriptional regulation,stimulation inferred by curator TFlink
PPARG CASP3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005CF5F CASP3 22058146 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 CASP3 18006822 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS000016FD1A CASP3 18006822 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS0000338542 CASP3 18006822 22743998 25416803 26574931 mrna cleavage,inhibition miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000083D87 CASP3 18006822 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS000016FF9C CASP3 18006822 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS0000122ED0 CASP3 25416803 26367177 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000005CF5F CASP3 22058146 22473208 25416803 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00000ED600 CASP3 20584986 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000170CF4 CASP3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 CASP3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00004505E4 CASP3 25041019 25416803 27016414 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000029979D CASP3 24252910 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000049FAE8 CASP3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 CASP3 25416803 26296645 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000B0E50 CASP3 24805821 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000B989F CASP3 24805821 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000246356 CASP3 23271051 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000285DCB CASP3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000013E79D CASP3 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D CASP3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 CASP3 22473208 25416803 26895377 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS0000065D58 CASP3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 CASP3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 CASP3 25416803 26307684 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000C0D3F CASP3 25416803 27517917 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00000EED18 CASP3 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS0000031E12 CASP3 25416803 25934573 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 CASP3 22135298 phosphorylation N/A PhosphoSite
GZMB CASP3 25361965 interaction type N/A PTMCode2
CASP3 GZMB 25361965 interaction type N/A PTMCode2
BIRC7 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC7 25361965 interaction type N/A PTMCode2
AIFM1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 AIFM1 25361965 interaction type N/A PTMCode2
CASP10 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP10 25361965 interaction type N/A PTMCode2
CRYAB CASP3 25361965 interaction type N/A PTMCode2
CASP3 CRYAB 25361965 interaction type N/A PTMCode2
CASP6 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP6 25361965 interaction type N/A PTMCode2
LMNB1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 LMNB1 25361965 interaction type N/A PTMCode2
EIF2S1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 EIF2S1 25361965 interaction type N/A PTMCode2
PRKCQ CASP3 25361965 interaction type N/A PTMCode2
CASP3 PRKCQ 25361965 interaction type N/A PTMCode2
CDKN1A CASP3 25361965 interaction type N/A PTMCode2
CASP3 CDKN1A 25361965 interaction type N/A PTMCode2
BMX CASP3 25361965 interaction type N/A PTMCode2
CASP3 BMX 25361965 interaction type N/A PTMCode2
VIM CASP3 25361965 interaction type N/A PTMCode2
CASP3 VIM 25361965 interaction type N/A PTMCode2
EIF2AK2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 EIF2AK2 25361965 interaction type N/A PTMCode2
CASP3 CFLAR 25361965 interaction type N/A PTMCode2
CFLAR CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP2 25361965 interaction type N/A PTMCode2
CASP2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 MET 25361965 interaction type N/A PTMCode2
MET CASP3 25361965 interaction type N/A PTMCode2
CASP3 BID 25361965 interaction type N/A PTMCode2
BID CASP3 25361965 interaction type N/A PTMCode2
CASP3 HCLS1 25361965 interaction type N/A PTMCode2
HCLS1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP9 25361965 interaction type N/A PTMCode2
CASP9 CASP3 25361965 interaction type N/A PTMCode2
CASP3 TRAF3 25361965 interaction type N/A PTMCode2
TRAF3 CASP3 25361965 interaction type N/A PTMCode2
CASP3 HIP1 25361965 interaction type N/A PTMCode2
HIP1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 HSPD1 25361965 interaction type N/A PTMCode2
HSPD1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 MAPT 25361965 interaction type N/A PTMCode2
MAPT CASP3 25361965 interaction type N/A PTMCode2
CASP3 PKN1 25361965 interaction type N/A PTMCode2
PKN1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 PTMA 25361965 interaction type N/A PTMCode2
PTMA CASP3 25361965 interaction type N/A PTMCode2
CASP3 HTT 25361965 interaction type N/A PTMCode2
HTT CASP3 25361965 interaction type N/A PTMCode2
CASP3 XIAP 25361965 interaction type N/A PTMCode2
XIAP CASP3 25361965 interaction type N/A PTMCode2
CASP3 ATN1 25361965 interaction type N/A PTMCode2
ATN1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP3 25361965 interaction type N/A PTMCode2
CASP3 TOP1 25361965 interaction type N/A PTMCode2
TOP1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A CASP3 25361965 interaction type N/A PTMCode2
CASP3 DEDD 25361965 interaction type N/A PTMCode2
DEDD CASP3 25361965 interaction type N/A PTMCode2
CASP3 FYN 25361965 interaction type N/A PTMCode2
FYN CASP3 25361965 interaction type N/A PTMCode2
CASP3 MCL1 25361965 interaction type N/A PTMCode2
MCL1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 SLK 25361965 interaction type N/A PTMCode2
SLK CASP3 25361965 interaction type N/A PTMCode2
CASP3 PKN2 25361965 interaction type N/A PTMCode2
PKN2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 STK4 25361965 interaction type N/A PTMCode2
STK4 CASP3 25361965 interaction type N/A PTMCode2
CASP3 GRIPAP1 25361965 interaction type N/A PTMCode2
GRIPAP1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 GATA1 25361965 interaction type N/A PTMCode2
GATA1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 DFFA 25361965 interaction type N/A PTMCode2
DFFA CASP3 25361965 interaction type N/A PTMCode2
CASP3 KRT18 25361965 interaction type N/A PTMCode2
KRT18 CASP3 25361965 interaction type N/A PTMCode2
CASP3 AKT2 25361965 interaction type N/A PTMCode2
AKT2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CAST 25361965 interaction type N/A PTMCode2
CAST CASP3 25361965 interaction type N/A PTMCode2
CASP3 ROCK1 25361965 interaction type N/A PTMCode2
ROCK1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 PARG 25361965 interaction type N/A PTMCode2
PARG CASP3 25361965 interaction type N/A PTMCode2
CASP3 DCC 25361965 interaction type N/A PTMCode2
DCC CASP3 25361965 interaction type N/A PTMCode2
CASP3 STK3 25361965 interaction type N/A PTMCode2
STK3 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 CASP3 25361965 interaction type N/A PTMCode2
CASP3 DBNL 25361965 interaction type N/A PTMCode2
DBNL CASP3 25361965 interaction type N/A PTMCode2
ARHGDIB CASP3 25361965 interaction type N/A PTMCode2
CASP3 ARHGDIB 25361965 interaction type N/A PTMCode2
CTTN CASP3 25361965 interaction type N/A PTMCode2
CASP3 CTTN 25361965 interaction type N/A PTMCode2
CDH1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CDH1 25361965 interaction type N/A PTMCode2
AKT1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 AKT1 25361965 interaction type N/A PTMCode2
RABEP1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 RABEP1 25361965 interaction type N/A PTMCode2
BIRC5 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC5 25361965 interaction type N/A PTMCode2
CAD CASP3 25361965 interaction type N/A PTMCode2
CASP3 CAD 25361965 interaction type N/A PTMCode2
APP CASP3 25361965 interaction type N/A PTMCode2
CASP3 APP 25361965 interaction type N/A PTMCode2
ACIN1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 ACIN1 25361965 interaction type N/A PTMCode2
ADD1 CASP3 25361965 interaction type N/A PTMCode2
CASP3 ADD1 25361965 interaction type N/A PTMCode2
BIRC2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC2 25361965 interaction type N/A PTMCode2
BIRC3 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 CASP3 11356849 12235123 14525934 25348397 9298992 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK9 CASP3 25348397 N/A physical interaction ComPPI
CDC42 CASP3 11278572 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PAK2 CASP3 14525934 16204230 24234451 25241761 25348397 9786869 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GMNN CASP3 25348397 N/A physical interaction ComPPI
BAG3 CASP3 25348397 N/A physical interaction ComPPI
CRYAB CASP3 18669646 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
VIM CASP3 10469173 11423904 11514563 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDKN1A CASP3 10022118 14525934 24234451 25241761 25348397 9660939 9799125 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
STAT1 CASP3 25348397 N/A physical interaction ComPPI
YWHAG CASP3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XIAP CASP3 11257232 11447297 11927604 14525934 19273858 24234451 25241761 25348397 9230442 9525868 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP9 CASP3 1067155 11230124 14525934 18723680 24234451 25241761 25348397 8900201 cleavage reaction,association,physical association experimental interaction detection,cleavage reaction,physical interaction,protease assay,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
ROCK1 CASP3 11283607 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAC1 CASP3 11278572 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HEY2 CASP3 25348397 N/A physical interaction ComPPI
VAV1 CASP3 10713703 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PRKCQ CASP3 14525934 25348397 9252332 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARHGDIB CASP3 14525934 18723680 24234451 25348397 8626669 cleavage reaction experimental interaction detection,cleavage reaction,protease assay,in vitro ComPPI,HPRD,IntAct
SP1 CASP3 10103059 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
MAPK8 CASP3 25348397 N/A physical interaction ComPPI
LYN CASP3 11526478 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HCLS1 CASP3 11689006 11988074 14525934 24234451 25241761 25348397 27898060 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
CASP3 DSG3 11500511 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 TFAP2A 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 EIF2AK2 11555640 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PRKCZ 11016947 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 RAD51 10082566 10998058 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 RB1 11420704 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 TGM2 10556977 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 CDH1 24234451 25241761 25348397 physical association physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
CASP3 BCAP31 14525934 25348397 9334338 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 HSPE1 10205158 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 SREBF2 14525934 25348397 27898060 8605870 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CASP3 NFE2L2 10510468 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CASP3 SRF 11387340 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 MEF2A 11904443 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PTBP1 12004072 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 PRKDC 14525934 25348397 8804412 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP3 IL18 14525934 25348397 9334240 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 PKN1 14525934 25348397 9751706 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP3 TRAF1 11098060 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 BIRC2 11084335 14525934 24234451 25348397 9384571 physical association experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
CASP3 BIRC3 14525934 25348397 9384571 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 CASP10 14525934 25348397 8755496 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 CASP8 11437602 14525934 18669646 24234451 25348397 N/A experimental interaction detection,physical interaction,protease assay,in vitro,in vivo ComPPI,HPRD,IntAct
CASP3 DFFA 11752060 14525934 24234451 25241761 25348397 9108473 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 MAP4K1 10602493 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 SRP72 14525934 25348397 9857079 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PXN 25348397 N/A in vitro ComPPI
CASP3 PKN2 14525934 25348397 9368003 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 GOLGA3 10791974 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 CASP4 14525934 25348397 9233763 9694885 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 MDM4 11840332 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 HNRNPU 10671544 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PICALM 10926122 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 IL16 25348397 N/A in vitro ComPPI
CASP3 PIP5K1A 25348397 N/A in vitro,in vivo ComPPI
CASP3 PDE5A 11602184 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 BIRC5 14525934 25348397 9850056 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 PARG 11053413 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 RABEP1 10608812 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 PSIP1 12181742 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 EIF2S1 10432301 10734073 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 EIF3J 10672017 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 EIF4B 10672017 11274152 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 ACIN1 10490026 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 BLM 11470874 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 KCNIP3 11278424 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 STK3 11278283 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 PSME3 11859414 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CASP3 BIRC7 11024045 11084335 14525934 24234451 25348397 physical association experimental interaction detection,physical interaction,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct
CASP3 DEDD 12235123 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 GORASP1 11815631 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP3 CAD 11854437 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 DCTN1 11425872 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 USO1 25348397 N/A physical interaction,in vivo ComPPI
CASP3 STK24 12107159 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 SLK 10611247 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 UBE4B 25348397 N/A in vitro ComPPI
CASP3 MAPK8IP3 10629060 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 SARS2 11331419 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CASP3 PDE10A 11602184 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 CAST 14525934 25348397 9705209 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 PLA2G4A 14525934 25348397 9875225 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 EIF4G2 25348397 N/A in vitro,in vivo ComPPI
CASP3 GRIPAP1 12207967 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CASP3 TRAF3 11098060 11261798 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CASP3 BRCA1 12149654 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 PPP3CA 11478781 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 RFC1 14525934 25348397 9235961 9351817 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 CTNNB1 14525934 24234451 25241761 25348397 9348292 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 CDK11A 25348397 N/A in vivo ComPPI
CASP3 BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP3 HSPD1 10205158 10205159 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CASP3 MLH1 14525934 15087450 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 DCC 11248093 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CASP3 CDC27 14525934 25348397 9618490 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 MET 14525934 15542841 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 SPTAN1 14525934 25348397 9811849 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 WEE1 14525934 25348397 9618490 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 AIFM1 14525934 25348397 27898060 9206994 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CASP3 AR 14525934 25348397 8626669 9208847 9535906 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 MCL1 14525934 15637055 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 CDK11B 25348397 N/A in vitro ComPPI
CASP3 APAF1 11550094 14525934 21827945 24234451 25348397 cleavage reaction experimental interaction detection,protease assay,in vitro,protease accessibility laddering ComPPI,HPRD,IntAct
CASP3 YWHAE 12657644 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
CASP3 STK4 11278283 11278782 14525934 24234451 25241761 25348397 9545236 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 CASP6 14525934 18723680 24234451 25241761 25348397 8900201 cleavage reaction,physical association experimental interaction detection,cleavage reaction,physical interaction,protease assay,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 TOP1 14525934 25348397 9933635 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 MDM2 14525934 21726810 24234451 25241761 25348397 9278461 protein cleavage,physical association experimental interaction detection,physical interaction,protease assay,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 NMT2 14525934 16530191 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CASP3 HIP1 14525934 16979168 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 GATA1 14525934 17167422 24234451 25348397 colocalization,protein cleavage experimental interaction detection,physical interaction,protease assay,in vitro,confocal microscopy ComPPI,HPRD,IntAct
CASP3 ADD1 10823823 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 FYN 10435619 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 GSN 14525934 25348397 9323209 9671712 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP3 RASA1 10200531 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 HTT 10770929 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 LMNB1 11901153 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP3 BCL2 11948397 14525934 25348397 9395403 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP3 MAPT 11162250 12888622 25348397 27898060 N/A in vitro,in vivo ComPPI,OmniPath
CASP3 MYL3 12186978 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 AKT1 12124386 14525934 17544405 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct
CASP3 BID 10364179 14525934 18723680 24234451 25348397 cleavage reaction experimental interaction detection,cleavage reaction,physical interaction,protease assay ComPPI,HPRD,IntAct
CASP3 CTTN 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CASP3 DBNL 25348397 N/A physical interaction ComPPI
CASP3 NDUFS1 25348397 N/A physical interaction ComPPI
CASP3 RNF2 25348397 N/A physical interaction ComPPI
CASP3 RBX1 25348397 N/A physical interaction ComPPI
CASP3 FBXW11 25348397 N/A physical interaction ComPPI
CASP3 BTRC 25348397 N/A physical interaction ComPPI
CASP3 HSPB1 25348397 N/A physical interaction ComPPI
CASP3 MDC1 25348397 N/A physical interaction ComPPI
CASP3 ELAVL1 25348397 N/A physical interaction ComPPI
CASP3 CDK2 25348397 N/A physical interaction ComPPI
CASP3 COPS6 25348397 N/A physical interaction ComPPI
CASP3 ZBTB16 25348397 N/A physical interaction ComPPI
CASP3 PARP1 17167422 24234451 25348397 7596430 protein cleavage physical interaction,protease assay,protein cleavage ComPPI,IntAct
CASP3 PLA2G4B 25348397 N/A physical interaction ComPPI
CASP3 GZMB 14525934 25348397 9233763 9694885 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP3 TNFSF10 25348397 N/A physical interaction ComPPI
CASP3 GLRX 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP3 SOCS5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP3 ARHGDIA 25348397 N/A physical interaction ComPPI
CASP3 CASP7 25348397 N/A physical interaction ComPPI
CASP3 PTGES3 18723680 24234451 25348397 cleavage reaction cleavage reaction,physical interaction,protease assay ComPPI,IntAct
CASP3 BAX 25348397 N/A physical interaction ComPPI
CASP3 BECN1 25348397 N/A physical interaction ComPPI
CASP3 ATG4D 25348397 N/A physical interaction ComPPI
CASP3 ARMT1 25348397 N/A physical interaction ComPPI
CASP3 IDH3B 25348397 N/A physical interaction ComPPI
CASP3 EEF2 25348397 N/A physical interaction ComPPI
CASP3 LCMT1 25348397 N/A physical interaction ComPPI
CASP3 SERPINB8 25348397 N/A physical interaction ComPPI
CASP3 APP 14525934 15178331 24234451 25241761 25348397 8943232 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
CASP3 AKT3 17544405 24234451 25241761 25348397 cleavage reaction,physical association physical interaction,enzymatic study,proximity ligation assay ComPPI,IntAct
CASP3 ERP44 25348397 N/A physical interaction ComPPI
CASP3 LSM14B 25348397 N/A physical interaction ComPPI
CASP3 SLC35A1 25348397 N/A physical interaction ComPPI
CASP3 KCNA10 25348397 N/A physical interaction ComPPI
CASP3 MAPK14 25348397 N/A physical interaction ComPPI
CASP3 ARNT 25348397 N/A physical interaction ComPPI
CASP3 SPP1 25348397 N/A protease assay,protein cleavage ComPPI
CASP3 PANX1 20944749 24234451 25348397 protein cleavage protease assay,protein cleavage ComPPI,IntAct
CASP3 TXN 17606900 24234451 25348397 protein cleavage,physical association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,isothermal titration calorimetry,pull down,physical interaction,protease assay,protein cleavage ComPPI,IntAct
CASP3 WNK3 16501604 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,antibody array ComPPI,IntAct,OmniPath
CASP3 AKT2 17544405 24234451 25348397 cleavage reaction enzymatic study ComPPI,IntAct
CASP3 NUCB2 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP3 RET 25348397 N/A protease assay ComPPI
CASP3 CALB1 22982862 24234451 25348397 27898060 N/A isothermal titration calorimetry ComPPI,IntAct,OmniPath
CASP3 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
CASP3 AKAP8 14525934 16227597 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,two hybrid ComPPI,HPRD,IntAct,OmniPath
CASP3 SOHLH1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMGB1 CASP3 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMX CASP3 11278797 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K14 CASP3 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CASP2 CASP3 25348397 N/A physical interaction ComPPI
CFLAR CASP3 14525934 25348397 9208847 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
THAP11 CASP3 14525934 18585351 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 PTMA 10675528 14525934 9334214 N/A experimental interaction detection HPRD
CASP3 CASP3 11257232 14525934 24234451 physical association experimental interaction detection,x-ray crystallography HPRD,IntAct
CASP3 BCAR1 10712510 14525934 N/A experimental interaction detection HPRD
CASP3 ATN1 14525934 9361003 N/A experimental interaction detection HPRD
CASP3 MAPK8IP1 21237154 27898060 N/A N/A OmniPath
CASP3 CLSPN 17431426 27898060 N/A N/A OmniPath
CASP3 SND1 19820703 27898060 N/A N/A OmniPath
SNRNP70 CASP3 27898060 8642305 N/A N/A OmniPath
CASP3 SPTAN1 27898060 8910516 9624143 9712874 9811849 inhibition,stimulant N/A OmniPath
CASP3 CTNNB1 25241761 27898060 9348292 inhibition,stimulant N/A OmniPath
CASP3 CDH1 11076937 25241761 27898060 N/A N/A OmniPath
CASP1 CASP3 27898060 8700869 stimulant N/A OmniPath
EGFR CASP3 11226410 27898060 stimulant N/A OmniPath
CASP4 CASP3 27898060 9233763 9694885 N/A N/A OmniPath
AFP CASP3 19267404 27898060 N/A N/A OmniPath
CASP3 CDKN1A 10022118 25241761 27898060 9660939 9799125 stimulant N/A OmniPath
CASP3 ITGB4 17178732 27898060 inhibition,stimulant N/A OmniPath
CASP3 HNRNPU 10671544 27898060 N/A N/A OmniPath
CASP3 RAD51 10082566 10998058 25241761 27898060 stimulant N/A OmniPath
CASP3 ACIN1 10490026 27898060 stimulant N/A OmniPath
CASP3 RB1 10822366 11420704 15735701 27898060 inhibition N/A OmniPath
DFFA CASP3 11406587 11752060 18723680 25241761 27898060 9108473 N/A N/A OmniPath
CASP3 DFFA 11406587 11752060 12655299 18723680 25241761 27898060 9108473 9422506 9422513 9786842 inhibition,stimulant N/A OmniPath
CASP3 EIF2AK2 11555640 27898060 N/A N/A OmniPath
CASP3 ROCK1 11283607 27898060 stimulant N/A OmniPath
ELAVL1 CASP3 15257295 27898060 N/A N/A OmniPath
GZMB CASP3 11696597 12745270 15569669 16415351 16495481 17008916 17179148 17283187 19103589 27898060 8700869 8755496 9233763 9694885 stimulant N/A OmniPath
APAF1 CASP3 11550094 12874265 27898060 stimulant N/A OmniPath
CASP3 CASP7 17899380 27898060 stimulant N/A OmniPath
CASP3 MAPK9 12821118 27898060 N/A N/A OmniPath
CASP3 BIRC6 15200957 15507451 27898060 inhibition N/A OmniPath
BIRC6 CASP3 15200957 15507451 27898060 inhibition N/A OmniPath
CASP3 CASP9 1067155 11230124 11242052 12181739 12620238 14585074 15507451 15657060 17437405 18723680 25241761 27898060 8900201 9390557 stimulant N/A OmniPath
CASP9 CASP3 1067155 10708865 11230124 11242052 12181739 12620238 14585074 15507451 15657060 15725726 17437405 18723680 25241761 27898060 8900201 9390557 9708736 stimulant N/A OmniPath
CASP3 BCL2 11948397 27898060 9395403 inhibition N/A OmniPath
CASP3 EIF3J 10672017 27898060 inhibition N/A OmniPath
APP CASP3 10409650 15178331 25241761 27898060 8943232 N/A N/A OmniPath
CASP3 APP 10409650 15178331 25241761 27898060 8943232 N/A N/A OmniPath
CDK2 CASP3 21319273 27898060 N/A N/A OmniPath
CASP3 MAVS 20032188 27898060 N/A N/A OmniPath
CASP3 BAD 15231831 27898060 stimulant N/A OmniPath
CASP3 GSN 27898060 9323209 9671712 9930654 inhibition,stimulant N/A OmniPath
CASP3 AKT1 10579725 12124386 17544405 27898060 inhibition N/A OmniPath
CASP3 XIAP 10548111 11157976 11230124 11257230 11257232 11359776 11447297 11927604 12181739 12529384 12624662 12874265 15014070 15200957 15507451 15650747 15725726 16543147 16869888 17069460 17291493 18521960 18723680 19559631 19698783 22072751 22815893 23074197 23979166 25241761 26186194 27898060 9230442 9384571 9525868 9545235 inhibition N/A OmniPath
XIAP CASP3 10508158 10548111 11157976 11230124 11257230 11257232 11359776 11447297 11583623 11927604 12181739 12529384 12624662 12874265 15014070 15200957 15507451 15650747 15725726 16543147 16869888 17069460 17291493 18521960 18723680 19559631 19698783 22072751 22815893 23074197 23979166 25241761 26186194 27898060 9230442 9384571 9525868 9545235 inhibition N/A OmniPath
CASP3 NUMA1 17401638 27898060 9463409 inhibition,stimulant N/A OmniPath
CASP3 IL33 19559631 27898060 N/A N/A OmniPath
CASP3 PTK2 10224094 27898060 9463408 inhibition N/A OmniPath
CASP3 STK4 11278283 11278782 25241761 27898060 9545236 stimulant N/A OmniPath
CASP3 NEDD4 27898060 9593687 N/A N/A OmniPath
CASP3 EIF4G3 10611228 10672017 27898060 inhibition,stimulant N/A OmniPath
CASP3 EIF2A 10734073 27898060 inhibition N/A OmniPath
CASP3 EIF4EBP1 10672017 27898060 inhibition N/A OmniPath
CASP3 COPS6 17337451 27898060 N/A N/A OmniPath
COPS6 CASP3 17337451 27898060 stimulant N/A OmniPath
CASP3 GORASP1 11815631 27898060 inhibition N/A OmniPath
CASP3 CASP2 11399776 18723680 27898060 9261102 9922454 stimulant N/A OmniPath
CASP3 MCL1 15014070 15637055 27898060 inhibition N/A OmniPath
MAPK14 CASP3 14970175 27898060 inhibition N/A OmniPath
CASP3 DFFB 27898060 9108473 stimulant N/A OmniPath
CASP3 PXN 11447317 11511102 11825902 27898060 inhibition N/A OmniPath
CASP3 CASP8 11437602 11832478 15014070 15254227 17179148 18458084 18669646 27898060 8962078 9208847 9765224 9922454 stimulant N/A OmniPath
CASP8 CASP3 11437602 11832478 15014070 15254227 16964285 17179148 18458084 18669646 21295084 27898060 8962078 9208847 9501089 9765224 9885230 9922454 9950028 stimulant N/A OmniPath
CASP3 NFKBIA 27898060 9367996 stimulant N/A OmniPath
E2F1 CASP3 18319725 18660752 27898060 stimulant N/A OmniPath
HNRNPD CASP3 15257295 27898060 N/A N/A OmniPath
CASP3 STK3 11278283 25241761 27898060 stimulant N/A OmniPath
VDR CASP3 18259074 18832097 27898060 stimulant N/A OmniPath
CASP3 CASP10 11717445 27898060 8755496 9765224 9922454 stimulant N/A OmniPath
CASP10 CASP3 11717445 27898060 8755496 9765224 9922454 stimulant N/A OmniPath
HSPB2 CASP3 18266962 27898060 inhibition N/A OmniPath
CASP3 EIF4G2 10371215 10611228 10672017 11175261 27898060 inhibition,stimulant N/A OmniPath
CASP3 PSIP1 12181742 18708362 27898060 inhibition N/A OmniPath
CASP3 GOLGA3 10791974 27898060 N/A N/A OmniPath
CASP3 MEF2A 11904443 27898060 N/A N/A OmniPath
CASP3 EIF4G1 10611228 27898060 9819442 inhibition,stimulant N/A OmniPath
CASP3 BCAR1 10712510 11447317 11511102 27898060 inhibition,stimulant N/A OmniPath
CASP3 EIF2S2 10672017 27898060 inhibition N/A OmniPath
CASP3 CASP6 17899380 18723680 25241761 27898060 8900201 9922454 stimulant N/A OmniPath
CASP6 CASP3 18723680 25241761 27898060 8900201 stimulant N/A OmniPath
CASP3 EIF2S3 10672017 27898060 inhibition N/A OmniPath
CASP3 BIRC2 11084335 11106668 12042762 17069460 19258326 27898060 9384571 9990849 inhibition N/A OmniPath
BIRC2 CASP3 11084335 11106668 11382748 12042762 17069460 19258326 27898060 9384571 9990849 inhibition N/A OmniPath
CASP3 BRCA1 12149654 27898060 N/A N/A OmniPath
BIRC3 CASP3 12042762 17069460 27898060 9384571 9990849 inhibition N/A OmniPath
CASP3 RELA 27898060 9500443 inhibition N/A OmniPath
CASP3 ATG4D 19549685 27898060 stimulant N/A OmniPath
CASP3 AKT3 17544405 25241761 27898060 N/A N/A OmniPath
AKT3 CASP3 17544405 25241761 27898060 N/A N/A OmniPath
CASP3 VIM 10469173 11423904 11514563 27898060 inhibition,stimulant N/A OmniPath
CASP3 PPP2CA 15569672 27898060 N/A N/A OmniPath
PPP2CA CASP3 15569672 27898060 N/A N/A OmniPath
BIRC5 CASP3 10587640 11024045 11170436 16540654 27898060 9384571 9850056 inhibition,stimulant N/A OmniPath
CASP3 PSEN1 10069390 27898060 N/A N/A OmniPath
CASP3 TP73 18362891 27898060 stimulant N/A OmniPath
PARP1 CASP3 11907276 17167422 18723680 19549685 19713971 22451931 27898060 7596430 8090205 9875225 N/A N/A OmniPath
CASP3 PARP1 10438458 11907276 17167422 18723680 19549685 19713971 22451931 27898060 7596430 7774019 8090205 9875225 inhibition N/A OmniPath
CASP3 AKT2 17544405 27898060 N/A N/A OmniPath
CASP3 IL18 27898060 9334240 N/A N/A OmniPath
CASP3 PAK2 16204230 25241761 27898060 9171063 9786869 stimulant N/A OmniPath
CASP3 EIF4B 10672017 11274152 27898060 inhibition,stimulant N/A OmniPath
CASP3 PKN2 27898060 9368003 N/A N/A OmniPath
CASP3 RBX1 17217622 27898060 N/A N/A OmniPath
CASP3 PPP2R5C 27898060 9582351 inhibition N/A OmniPath
CASP3 MAPK8 12821118 27898060 N/A N/A OmniPath
CASP3 BTRC 17217622 27898060 N/A N/A OmniPath
CASP3 MDM4 11840332 27898060 N/A N/A OmniPath
CASP3 PRKDC 12867423 27898060 8670824 8798786 8804412 inhibition,stimulant N/A OmniPath
CASP3 IKBKB 11741536 27898060 9367996 inhibition N/A OmniPath
CASP3 PTCH1 12907805 23074268 27898060 inhibition N/A OmniPath
RNF7 CASP3 17217622 27898060 N/A N/A OmniPath
CASP3 CD247 12208735 27898060 N/A N/A OmniPath
CASP3 PTGES3 19559631 27898060 N/A N/A OmniPath
GZMM CASP3 16818775 27898060 N/A N/A OmniPath
CASP3 ARHGDIA 19559631 27898060 N/A N/A OmniPath
TCP10L CASP3 17765974 27898060 N/A N/A OmniPath
CASP3 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
PLA2G4A CASP3 27898060 9875225 N/A N/A OmniPath
CASP3 BMX 11278797 27898060 N/A N/A OmniPath
CASP3 MYL3 12186978 27898060 N/A N/A OmniPath
CASP3 PTBP1 12004072 27898060 stimulant N/A OmniPath
CASP3 FBXW11 17217622 27898060 N/A N/A OmniPath
CASP3 HDAC7 18458084 27898060 N/A N/A OmniPath
CASP3 PROKR1 11555640 27898060 inhibition N/A OmniPath
CASP3 MEF2B 11904443 27898060 inhibition N/A OmniPath
NAIP CASP3 11896143 27898060 inhibition N/A OmniPath
CASP3 PIP4K2A 11042212 27898060 inhibition N/A OmniPath
CASP3 STK24 12107159 27898060 N/A N/A OmniPath
CASP3 GAS2 10564664 27898060 stimulant N/A OmniPath
PPP2R5B CASP3 15569672 27898060 stimulant N/A OmniPath
PPP2CB CASP3 15569672 27898060 N/A N/A OmniPath
CASP3 PIP5K1A 11042212 27898060 stimulant N/A OmniPath
CASP3 DSG3 11500511 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B35B2 CASP3 17416635 27087310 direct interaction,inhibition N/A NPInter

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