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GENE：CASP6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP6
FullNmae caspase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1507
EnsembleID ENSG00000138794
Uniprot P55212

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP6 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP6 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP6 necroptosis 32298652 Furthermore, we demonstrate that caspase-6 promotes the activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in host defense against influenza A virus (IAV) infection. retulator signature
CASP6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP6 apoptosis 27911442 Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease. retulator signature

Go Annotation:

GeneSymbol Go id
CASP6 GO:0002218,GO:0004197,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006508,GO:0006915,GO:0006915,GO:0008234,GO:0016540,GO:0030855,GO:0032991,GO:0042802,GO:0043065,GO:0043067,GO:0060545,GO:0070269,GO:0072332,GO:0072734,GO:0097153,GO:0097153,GO:0097194,GO:0097200,GO:0097200,GO:0097284

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP6 hsa:839 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP6 hsa:839 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CASP6 XIAP 15200957 23180781 9545235 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
CASP6 TRAF1 11098060 23180781 cleavage reaction cleavage reaction InnateDB
COPS6 CASP6 17337451 23180781 cleavage reaction cleavage reaction InnateDB
HDAC7 CASP6 18458084 23180781 cleavage reaction protease assay InnateDB
APP CASP6 10409650 23180781 cleavage reaction protease assay InnateDB
CASP6 CASP3 23180781 8900201 protein cleavage protease assay InnateDB
CASP6 CASP6 23180781 8900201 protein cleavage protease assay InnateDB
CASP6 IRAK3 21098228 23180781 protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CASP6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CASP6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CASP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CASP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CASP6 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
NUAK1 CASP6 22135298 phosphorylation N/A PhosphoSite
CASP6 APP 25361965 interaction type N/A PTMCode2
APP CASP6 25361965 interaction type N/A PTMCode2
CASP6 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP6 25361965 interaction type N/A PTMCode2
CASP6 PPL 25361965 interaction type N/A PTMCode2
PPL CASP6 25361965 interaction type N/A PTMCode2
CASP6 SATB1 25361965 interaction type N/A PTMCode2
SATB1 CASP6 25361965 interaction type N/A PTMCode2
CASP6 XIAP 25361965 interaction type N/A PTMCode2
XIAP CASP6 25361965 interaction type N/A PTMCode2
CASP6 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP6 25361965 interaction type N/A PTMCode2
CASP6 TOP1 25361965 interaction type N/A PTMCode2
TOP1 CASP6 25361965 interaction type N/A PTMCode2
CASP6 LMNA 25361965 interaction type N/A PTMCode2
LMNA CASP6 25361965 interaction type N/A PTMCode2
CASP6 TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A CASP6 25361965 interaction type N/A PTMCode2
CASP6 KRT18 25361965 interaction type N/A PTMCode2
KRT18 CASP6 25361965 interaction type N/A PTMCode2
LMNB1 CASP6 25361965 interaction type N/A PTMCode2
CASP6 LMNB1 25361965 interaction type N/A PTMCode2
VIM CASP6 25361965 interaction type N/A PTMCode2
CASP6 VIM 25361965 interaction type N/A PTMCode2
CASP6 CASP6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 CASP6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPL CASP6 14525934 15654952 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KRT18 CASP6 14525934 25348397 9298992 N/A experimental interaction detection,in vitro ComPPI,HPRD
CRYAB CASP6 25348397 N/A physical interaction ComPPI
VIM CASP6 10469173 11423904 11514563 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LMNA CASP6 25348397 N/A in vitro,in vivo ComPPI
XIAP CASP6 25348397 N/A physical interaction ComPPI
DDIT4L CASP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SP1 CASP6 25348397 N/A physical interaction ComPPI
CASP3 CASP6 14525934 18723680 24234451 25241761 25348397 8900201 cleavage reaction,physical association experimental interaction detection,cleavage reaction,physical interaction,protease assay,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
RB1 CASP6 14525934 15735701 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SRF CASP6 11387340 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TFAP2A CASP6 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 TRAF1 11098060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP6 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP6 CASP8 12232792 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP6 SATB1 11463840 14525934 18408014 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP6 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 EIF2S1 10432301 10734073 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 UBE4B 25348397 N/A in vitro ComPPI
CASP6 NUAK1 14525934 15273717 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 PCYT1A 12052891 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 SRP72 14525934 25348397 9857079 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 PSME3 11859414 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 PRKCZ 11016947 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 DSP 14525934 15500642 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 TOP1 14525934 25348397 9933635 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 HTT 10770929 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP6 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 LMNB1 11331782 11901153 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 MAPT 25348397 N/A in vitro,in vivo ComPPI
CASP6 CHD3 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CASP6 UBE4A 25348397 N/A physical interaction ComPPI
CASP6 TAB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP6 COPS6 25348397 N/A physical interaction ComPPI
CASP6 PRKAB2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP6 IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP6 APP 10438520 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
CASP6 CASP7 18723680 24234451 25348397 cleavage reaction cleavage reaction,protease assay ComPPI,IntAct
CASP6 NUCB2 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP6 PARP10 23305266 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP6 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
CASP6 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP6 PKIA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP6 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK6 CASP6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CFLAR CASP6 14525934 25348397 9228018 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NUCB1 CASP6 18154733 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CASP6 CASP6 20890311 21988832 24234451 25416956 physical association two hybrid,x-ray crystallography,two hybrid array,two hybrid prey pooling approach IntAct
LMNA CASP6 11953316 16518869 27898060 8978814 N/A N/A OmniPath
CASP6 LMNA 11058599 11953316 27898060 8710882 8978814 inhibition,stimulant N/A OmniPath
CASP3 CASP6 17899380 18723680 25241761 27898060 8900201 9922454 stimulant N/A OmniPath
CASP6 CASP3 18723680 25241761 27898060 8900201 stimulant N/A OmniPath
CASP9 CASP6 12097334 14686614 16521476 27898060 9651578 stimulant N/A OmniPath
CASP6 NUMA1 17401638 27898060 9463409 inhibition,stimulant N/A OmniPath
CASP6 NEDD4 27898060 9593687 N/A N/A OmniPath
TP53 CASP6 12089322 18431400 27898060 stimulant N/A OmniPath
CASP6 CASP8 11455969 11832478 12232792 27898060 8962078 9727491 stimulant N/A OmniPath
CASP8 CASP6 11455969 11832478 12232792 18329793 27898060 8962078 9727491 stimulant N/A OmniPath
NUAK1 CASP6 15273717 22433863 22483120 27898060 N/A N/A OmniPath
CASP6 VIM 10469173 11423904 11514563 27898060 inhibition,stimulant N/A OmniPath
CASP6 HIPK2 16601678 19788416 27898060 stimulant N/A OmniPath
CASP6 PSEN1 10069390 27898060 N/A N/A OmniPath
TP73 CASP6 19788416 27898060 stimulant N/A OmniPath
DAPK1 CASP6 15273717 27898060 N/A N/A OmniPath
CASP6 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
CASP6 PCYT1A 12052891 27898060 N/A N/A OmniPath
CASP6 SATB1 11463840 18408014 27898060 stimulant N/A OmniPath

Visualization










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