GENE：WFS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WFS1 |
| FullNmae | wolframin ER transmembrane glycoprotein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12762 |
| EnsembleID | ENSG00000109501 |
| Uniprot | O76024 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WFS1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WFS1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| WFS1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WFS1 | GO:0000122,GO:0001822,GO:0003091,GO:0005515,GO:0005516,GO:0005783,GO:0005783,GO:0005788,GO:0005789,GO:0005789,GO:0005789,GO:0006983,GO:0006983,GO:0007601,GO:0007605,GO:0017148,GO:0022417,GO:0030141,GO:0030425,GO:0030433,GO:0030433,GO:0030672,GO:0030968,GO:0031016,GO:0031398,GO:0031398,GO:0031625,GO:0032469,GO:0034976,GO:0042048,GO:0042593,GO:0043066,GO:0043069,GO:0043433,GO:0043524,GO:0045927,GO:0048306,GO:0050821,GO:0050821,GO:0050821,GO:0050821,GO:0050877,GO:0051117,GO:0051247,GO:0051928,GO:0055074,GO:0055074,GO:0070628,GO:0140297,GO:1902236,GO:1903573,GO:1903892,GO:1904294,GO:2000675 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| WFS1 | hsa:7466 | path:hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | WFS1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | WFS1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | WFS1 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | WFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| XBP1 | WFS1 | 16539657 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YIPF3 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB3BP | WFS1 | 16169070 24234451 25348397 | physical association | two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| PSMA5 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | WFS1 | 17110338 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| MAPK6 | WFS1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| EIF6 | WFS1 | 14525934 16169070 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| SYVN1 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ATF6 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ANTXR1 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| SMURF1 | WFS1 | 21454619 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| CD79A | WFS1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TERF1 | WFS1 | 21044950 24234451 25348397 | physical association | pull down,physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| ADIPOR1 | WFS1 | 25348397 | N/A | physical interaction | ComPPI |
| WFS1 | DRD2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| F2RL1 | WFS1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| LTB4R2 | WFS1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |