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GENE：ABL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ABL2
FullNmae ABL proto-oncogene 2, non-receptor tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:77
EnsembleID ENSG00000143322
Uniprot P42684

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ABL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ABL2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ABL2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ABL2 GO:0000287,GO:0001784,GO:0003785,GO:0004672,GO:0004713,GO:0004713,GO:0004713,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007155,GO:0007165,GO:0007204,GO:0010506,GO:0010863,GO:0010976,GO:0015629,GO:0018108,GO:0030100,GO:0030145,GO:0030155,GO:0032956,GO:0035024,GO:0035640,GO:0036211,GO:0042981,GO:0051015,GO:0051353,GO:0071300,GO:1903905,GO:2000145,GO:2000406

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ABL2 hsa:27 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
ABL2 hsa:27 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
ABL2 hsa:27 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
ABL2 hsa:27 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL6 ABL2 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLCG1 ABL2 17474147 23180781 physical association peptide array,pull down InnateDB
ABL2 SORBS2 21071413 23331499 9211900 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
CRK ABL2 20005715 interaction type N/A PSP
GRB2 ABL2 20005715 interaction type N/A PSP,SignaLink
NCK1 ABL2 20005715 interaction type N/A PSP,SignaLink
PIK3R1 ABL2 20005715 interaction type N/A PSP,SignaLink
CRK ABL2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ABL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ABL2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ABL2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ABL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BTF3 ABL2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A2 ABL2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A3 ABL2 17312387 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000821E0 ABL2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000042E1F ABL2 24464651 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003E226A ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 ABL2 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000023BE29 ABL2 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 ABL2 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF ABL2 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA ABL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE ABL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 ABL2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 ABL2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC ABL2 23824327 24906430 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C ABL2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ABL2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 ABL2 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 ABL2 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000EF0B ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D12AC ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF ABL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C ABL2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 ABL2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 ABL2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F ABL2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 ABL2 25416803 26766902 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C0D3F ABL2 25416803 27517917 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000083D87 ABL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075ABF4 ABL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000076B539 ABL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD ABL2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PDGFRB ABL2 22135298 phosphorylation N/A PhosphoSite
ABL1 ABL2 22135298 phosphorylation N/A PhosphoSite
ABL2 CAT 22135298 phosphorylation N/A PhosphoSite
ABL2 ABL2 22135298 phosphorylation N/A PhosphoSite
ABL2 CEBPB 22135298 phosphorylation N/A PhosphoSite
ABL2 HRAS 22135298 phosphorylation N/A PhosphoSite
ABL2 CRK 22135298 phosphorylation N/A PhosphoSite
ABL2 PSMA7 22135298 phosphorylation N/A PhosphoSite
ABL2 LGALS3 22135298 phosphorylation N/A PhosphoSite
ABL2 PDGFRB 22135298 phosphorylation N/A PhosphoSite
ABL2 GPX1 22135298 phosphorylation N/A PhosphoSite
ABL2 ITGB1 22135298 phosphorylation N/A PhosphoSite
ABL2 SIVA1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NCK2 ABL2 25348397 N/A physical interaction ComPPI
OIP5 ABL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA8 ABL2 24234451 25348397 29568061 association pull down,physical interaction ComPPI,IntAct
HSPBP1 ABL2 25348397 N/A physical interaction ComPPI
CRK ABL2 11956190 12198159 14525934 15886098 17474147 19380743 24234451 25348397 8875975 9480911 9642287 phosphorylation reaction,association,physical association experimental interaction detection,peptide array,physical interaction,protein kinase assay,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
RIN1 ABL2 14525934 15886098 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD,IntAct
ERBB2 ABL2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PTPN18 ABL2 23322602 24234451 25348397 association pull down ComPPI,IntAct
HRAS ABL2 15886098 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PECAM1 ABL2 23322602 24234451 25348397 association pull down ComPPI,IntAct
ERBB4 ABL2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
KIT ABL2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R1 ABL2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SRC ABL2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DOK1 ABL2 25348397 N/A physical interaction ComPPI
NCK1 ABL2 17474147 24234451 25241761 25348397 physical association peptide array,physical interaction,proximity ligation assay ComPPI,IntAct
EPHB2 ABL2 11494128 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GRB2 ABL2 17474147 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
AR ABL2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R3 ABL2 25348397 N/A physical interaction ComPPI
NTRK1 ABL2 25348397 N/A physical interaction ComPPI
JAK1 ABL2 25348397 N/A physical interaction ComPPI
CAV1 ABL2 25348397 N/A protein array,physical interaction ComPPI
MAP3K10 ABL2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PKM ABL2 25348397 N/A protein kinase assay ComPPI
SORBS2 ABL2 14525934 25348397 9211900 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TRIP10 ABL2 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD4L ABL2 25348397 N/A physical interaction ComPPI
MET ABL2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MDM2 ABL2 25348397 N/A physical interaction ComPPI
ABI1 ABL2 20598684 24234451 25348397 27898060 7590237 N/A array technology ComPPI,IntAct,OmniPath
AXL ABL2 25348397 N/A physical interaction ComPPI
EGFR ABL2 16273093 24234451 24658140 25348397 physical association protein array,ubiquitin reconstruction,physical interaction ComPPI,IntAct
SIVA1 ABL2 11278261 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCR ABL2 1383690 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TPD52L1 ABL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTTN ABL2 21257711 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ABI2 ABL2 25348397 N/A physical interaction ComPPI
GPX1 ABL2 12893824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SF1 ABL2 24234451 25348397 26420826 physical association two hybrid fragment pooling approach ComPPI,IntAct
MED28 ABL2 16964398 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
FYN ABL2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NEDD4 ABL2 25348397 N/A physical interaction ComPPI
CD84 ABL2 23322602 24234451 25348397 association pull down ComPPI,IntAct
CDC37 ABL2 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 ABL2 25348397 N/A physical interaction ComPPI
STAT3 ABL2 25348397 N/A physical interaction ComPPI
PSMA7 ABL2 25348397 N/A physical interaction ComPPI
FBXO38 ABL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ABL2 CAT 12777400 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ABL2 HCK 12748290 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo ComPPI,HPRD,IntAct
ABL2 ABL1 12569093 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ABL2 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ABL2 NMES1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ABL2 BAG5 25348397 N/A physical interaction ComPPI
ABL2 PLCG1 17474147 24234451 25348397 physical association fluorescence technology,peptide array,pull down ComPPI,IntAct
ABL2 MPIG6B 23322602 24234451 25348397 association pull down ComPPI,IntAct
ABL2 CASS4 23322602 24234451 25348397 association pull down ComPPI,IntAct
ABL2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
ABL2 FLT3 24234451 28086240 physical association anti tag coimmunoprecipitation,protein array IntAct
PRKG1 ABL2 15735735 27898060 N/A N/A OmniPath
SRC ABL2 12522270 12748290 17474147 18083107 19534553 20841568 27898060 stimulant N/A OmniPath
ABL2 DBN1 17892306 20841568 27898060 N/A N/A OmniPath
ABL2 CTTN 17306540 20841568 21257711 27898060 stimulant N/A OmniPath
HCK ABL2 12748290 20841568 21988832 27898060 stimulant N/A OmniPath
ABL2 NOD2 21552281 27898060 N/A N/A OmniPath
ABL2 ITGB1 17473008 20702409 23092334 25694433 27898060 N/A N/A OmniPath
PDGFRB ABL2 19275932 27898060 N/A N/A OmniPath
ABL2 CHUK 21552281 27898060 N/A N/A OmniPath
ABL2 GPX1 12893824 20841568 27898060 stimulant N/A OmniPath
ABL2 SIVA1 11278261 20841568 27898060 stimulant N/A OmniPath
ABL2 LGALS3 20150913 27898060 stimulant N/A OmniPath
ABL2 PSMA7 16678104 25620702 27898060 inhibition N/A OmniPath
ABL2 WASL 16199863 20841568 27898060 stimulant N/A OmniPath
ABL2 SORBS2 20841568 27898060 9211900 stimulant N/A OmniPath
ABL2 CEBPB 19563810 27898060 stimulant N/A OmniPath
ABL1 ABL2 12569093 15735735 20841568 27898060 stimulant N/A OmniPath
ABL2 CASP8 18458084 27898060 N/A N/A OmniPath
CASP8 ABL2 18458084 27898060 N/A N/A OmniPath
ABL2 RIN1 15886098 15951569 18083107 19534553 20841568 27898060 9144171 stimulant N/A OmniPath
RIN1 ABL2 15886098 20841568 27898060 9144171 stimulant N/A OmniPath
ABL2 CAT 12777400 12950161 20841568 27898060 stimulant N/A OmniPath
ABL2 CRK 11956190 12198159 15886098 17016520 17474147 19380743 20068231 21602891 25814554 27898060 8194526 8875975 9480911 9642287 inhibition,stimulant N/A OmniPath
ABL2 CDK7 27898060 9725911 N/A N/A OmniPath
ABL2 RAPH1 20417104 20841568 27898060 stimulant N/A OmniPath
ABL2 ARHGAP35 15592455 17389395 18083107 18829532 19534553 19690332 27898060 N/A N/A OmniPath
ABL2 POLR2B 27898060 7504297 N/A N/A OmniPath
ABL2 IKBKB 21552281 27898060 N/A N/A OmniPath
ABL2 NOD1 21552281 27898060 N/A N/A OmniPath
ABL2 CDCP1 15851033 27898060 N/A N/A OmniPath
ABL2 PECAM1 15201144 15766557 27898060 N/A N/A OmniPath

Visualization










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