Gene Information gene info

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GENE：AGER

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AGER
FullNmae advanced glycosylation end-product specific receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:320
EnsembleID ENSG00000204305
Uniprot Q15109

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AGER autophagy 22722139 In pancreatic tumor cell lines, AGER-mediated autophagy promotes interleukin-6 (IL6)-induced phosphorylation of signal transducer and activator of transcription 3 (pSTAT3) and mitochondrial localization of pSTAT3. retulator signature

Go Annotation:

GeneSymbol Go id
AGER GO:0001540,GO:0001540,GO:0001540,GO:0001540,GO:0001650,GO:0001666,GO:0001774,GO:0001774,GO:0001914,GO:0001934,GO:0004888,GO:0005044,GO:0005055,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006897,GO:0006954,GO:0007155,GO:0007166,GO:0007611,GO:0009611,GO:0009986,GO:0010255,GO:0016324,GO:0030054,GO:0031175,GO:0032693,GO:0032722,GO:0032731,GO:0032735,GO:0032755,GO:0032760,GO:0034116,GO:0038023,GO:0038023,GO:0042104,GO:0042802,GO:0044548,GO:0044877,GO:0045056,GO:0046330,GO:0048143,GO:0048167,GO:0050727,GO:0050785,GO:0050930,GO:0051092,GO:0060090,GO:0070374,GO:0071639,GO:0072657,GO:0098794,GO:0150003,GO:0150104,GO:0150104,GO:1900271,GO:1900272,GO:1900272,GO:1900453,GO:1900744,GO:1900744,GO:1900745,GO:1901222,GO:1901224,GO:1902961,GO:1903523,GO:1904472,GO:1904645,GO:1904645,GO:1904646,GO:2000439,GO:2000514,GO:2001200

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AGER hsa:177 path:hsa04148 Efferocytosis - Homo sapiens (human)
AGER hsa:177 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
AGER hsa:177 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
AGER hsa:177 path:hsa05010 Alzheimer disease - Homo sapiens (human)
AGER hsa:177 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
AGER hsa:177 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
AGER hsa:177 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AGER TLR9 17417641 23180781 physical association anti tag coimmunoprecipitation,amplified luminescent proximity homogeneous assay InnateDB
HMGB1 AGER 19727205 23180781 physical association solid phase assay InnateDB
AGER S100A12 19727205 23180781 physical association solid phase assay InnateDB
AGER PRKCZ 21829704 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
AGER MYD88 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
AGER TIRAP 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
AGER IRAK4 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
AGER C1QA 22386596 23180781 physical association unspecified method,surface plasmon resonance array InnateDB
AGER C1QC 22386596 23180781 physical association unspecified method,surface plasmon resonance array InnateDB
S100A4 AGER 23180781 23667563 physical association affinity technology InnateDB
AGER S100A9 23180781 23667563 physical association affinity technology InnateDB
AGER S100A4 23180781 23667563 physical association affinity technology InnateDB
CIRBP AGER 23180781 24097189 physical association surface plasmon resonance array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 AGER 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 AGER 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 AGER 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 AGER 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA AGER 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 AGER 18622638 19616578 trascriptional regulation,stimulation inferred by curator TFlink
PPARG AGER 18855759 trascriptional regulation,stimulation inferred by curator TFlink
RELA AGER 18622638 19616578 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 AGER N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000040EE1D AGER 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 AGER 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TTR AGER 14525934 16716307 24234451 25348397 27898060 N/A experimental interaction detection,competition binding,saturation binding,in vitro ComPPI,HPRD,IntAct,OmniPath
S100B AGER 10399917 14525934 17660747 17726019 24234451 25348397 27898060 N/A experimental interaction detection,filter binding,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vivo ComPPI,HPRD,IntAct,OmniPath
S100P AGER 14525934 14617629 16061848 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
S100A1 AGER 11007787 14525934 17726019 24234451 25348397 27898060 N/A experimental interaction detection,surface plasmon resonance,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
NCK1 AGER 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 AGER 17474147 21706016 24234451 25348397 association,physical association anti tag coimmunoprecipitation,peptide array,physical interaction ComPPI,IntAct
RHOA AGER 19944695 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DIAPH1 AGER 18922799 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
SEC61B AGER 25348397 N/A physical interaction ComPPI
TIRAP AGER 21829704 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
AGER S100A12 10399917 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AGER APP 25348397 N/A physical interaction ComPPI
AGER NRP1 25348397 N/A physical interaction ComPPI
AGER FGF2 25348397 N/A physical interaction ComPPI
AGER FGFR1 25348397 N/A physical interaction ComPPI
AGER EGFR 16954185 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AGER CMTM7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AGER TTMP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AGER CREB3 25348397 N/A two hybrid bait and prey pooling approach ComPPI
AGER PRKCZ 21829704 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
AGER MYD88 21829704 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
AGER IRAK4 21829704 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
AGER TICAM2 21829704 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HMGB1 AGER 14525934 24234451 24474694 25348397 9812979 N/A experimental interaction detection,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
CSTF2 AGER 25348397 N/A physical interaction ComPPI
AGER AGER 24119142 24234451 N/A x-ray crystallography IntAct
ITGB1 AGER 24234451 30021884 physical association cross-linking study IntAct
TLR9 AGER 17417641 27898060 N/A N/A OmniPath
PRKCZ AGER 21829704 27898060 N/A N/A OmniPath
AGER PRKCZ 21829704 27898060 N/A N/A OmniPath

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