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GENE：BCL2L1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCL2L1
FullNmae BCL2 like 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:992
EnsembleID ENSG00000171552
Uniprot Q07817

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCL2L1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L1 autophagy 26060891 Here, we reveal an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary. retulator signature
BCL2L1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BCL2L1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BCL2L1 anoikis 10769035 In addition, we found that enforced downregulation of Bcl-X(L) in the ras-transformed cells promotes anoikis. retulator signature

Go Annotation:

GeneSymbol Go id
BCL2L1 GO:0001541,GO:0001701,GO:0001836,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005743,GO:0005759,GO:0005783,GO:0005813,GO:0005829,GO:0006897,GO:0007281,GO:0007283,GO:0008584,GO:0008630,GO:0008637,GO:0009566,GO:0019050,GO:0019901,GO:0030672,GO:0031965,GO:0032465,GO:0032946,GO:0034097,GO:0035234,GO:0040008,GO:0042802,GO:0042803,GO:0043066,GO:0043524,GO:0044565,GO:0046898,GO:0046902,GO:0046982,GO:0050673,GO:0051093,GO:0051402,GO:0051434,GO:0051607,GO:0051881,GO:0070584,GO:0071230,GO:0071312,GO:0071480,GO:0071839,GO:0090201,GO:0097048,GO:0097136,GO:0097192,GO:0097284,GO:1900118,GO:1902042,GO:1902230,GO:1902236,GO:1903077,GO:2000242,GO:2000669,GO:2001240,GO:2001243,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCL2L1 hsa:598 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04140 Autophagy - animal - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04210 Apoptosis - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05012 Parkinson disease - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05131 Shigellosis - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05162 Measles - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
BCL2L1 hsa:598 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2L1 MAPK8 15733859 23180781 phosphorylation reaction in-gel kinase assay InnateDB
BAX BCL2L1 14766748 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 BCL2L1 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
BAD BCL2L1 18628207 23109003 23180781 25416956 7834748 9305851 inhibition,physical association anti tag coimmunoprecipitation,two hybrid InnateDB,SignaLink
BECN1 BCL2L1 17659302 18628207 18641390 19049976 19713971 23180781 physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,isothermal titration calorimetry,nuclear magnetic resonance,pull down InnateDB
BCL2L1 ATG5 16998475 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L1 BAD 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L1 BAX 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L1 BAK1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIK BCL2L1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L1 VDAC2 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
VDAC2 BCL2L1 22705850 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L1 BCL2L1 26467481 9539746 bind,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR BCL2L1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPB BCL2L1 19043455 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ESR1 BCL2L1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 BCL2L1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 BCL2L1 17420275 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BCL2L1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 BCL2L1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 BCL2L1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 BCL2L1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 BCL2L1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BCL2L1 16911523 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BCL2L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BCL2L1 18172861 18971253 9000137 trascriptional regulation,stimulation inferred by curator TFlink
BCL6 BCL2L1 11777915 trascriptional regulation,stimulation inferred by curator TFlink
JUN BCL2L1 16911523 trascriptional regulation,stimulation inferred by curator TFlink
MTA1 BCL2L1 11948399 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BCL2L1 10733571 10925251 12176906 12226754 14739605 14978135 15231833 15756023 15856023 15986355 16453001 16904634 17673602 18222423 18223231 20066113 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 BCL2L1 16085054 trascriptional regulation,stimulation inferred by curator TFlink
NUPR1 BCL2L1 18690848 trascriptional regulation,stimulation inferred by curator TFlink
PAX3 BCL2L1 10871843 trascriptional regulation,stimulation inferred by curator TFlink
PPARG BCL2L1 14960510 trascriptional regulation,stimulation inferred by curator TFlink
RELA BCL2L1 10733571 10925251 12226754 14739605 14978135 15231833 15756023 15856023 15986355 16453001 16904634 17673602 18223231 20066113 20585448 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 BCL2L1 16091421 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 BCL2L1 11369651 15184887 15469392 15805299 16384639 16651438 17880940 18222423 18790750 20067773 20069389 20654581 21172343 21344490 21435102 trascriptional regulation,stimulation inferred by curator TFlink
STAT5A BCL2L1 11756417 trascriptional regulation,stimulation inferred by curator TFlink
STAT5B BCL2L1 20585448 trascriptional regulation,stimulation inferred by curator TFlink
MYB BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB2 BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PGR BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink
REL BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT6 BCL2L1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000031E12 BCL2L1 20347499 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029979D BCL2L1 20347499 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003380CC BCL2L1 18692484 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS00001919B0 BCL2L1 20039318 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000031E12 BCL2L1 20347499 22743998 22917031 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000029979D BCL2L1 20347499 22743998 25416803 26701625 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00001919B0 BCL2L1 20039318 22743998 23519249 24747968 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00003380CC BCL2L1 18692484 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000065D58 BCL2L1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00005651EE BCL2L1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED BCL2L1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000011A030 BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C5774 BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023F008 BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000060AABB BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 BCL2L1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077DDE BCL2L1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D BCL2L1 22012620 25416803 27245778 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000CF1D2 BCL2L1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 BCL2L1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 BCL2L1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000032BD73 BCL2L1 25416803 26276722 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 BCL2L1 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00000A939F BCL2L1 25416803 25875481 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000157F5 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032015F BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009A9A2 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002152A8 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000136174 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000519450 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237E04 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A760 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000508C13 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008B558 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000221168 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037E170 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759B6A BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023133F BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000544FF1 BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005D986D BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B BCL2L1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPKAPK2 BCL2L1 22135298 phosphorylation N/A PhosphoSite
GSK3B BCL2L1 22135298 phosphorylation N/A PhosphoSite
MAPK14 BCL2L1 22135298 phosphorylation N/A PhosphoSite
GSK3A BCL2L1 22135298 phosphorylation N/A PhosphoSite
PLK1 BCL2L1 22135298 phosphorylation N/A PhosphoSite
MAPK9 BCL2L1 22135298 phosphorylation N/A PhosphoSite
MAPK8 BCL2L1 22135298 phosphorylation N/A PhosphoSite
PLK3 BCL2L1 22135298 phosphorylation N/A PhosphoSite
FKBP8 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 FKBP8 25361965 interaction type N/A PTMCode2
BCL2L1 AVEN 25361965 interaction type N/A PTMCode2
AVEN BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CYCS 25361965 interaction type N/A PTMCode2
CYCS BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BAD 25361965 interaction type N/A PTMCode2
BAD BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 SPNS1 25361965 interaction type N/A PTMCode2
SPNS1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CFLAR 25361965 interaction type N/A PTMCode2
CFLAR BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CASP2 25361965 interaction type N/A PTMCode2
CASP2 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BID 25361965 interaction type N/A PTMCode2
BID BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 PPP1CA 25361965 interaction type N/A PTMCode2
PPP1CA BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 PMAIP1 25361965 interaction type N/A PTMCode2
PMAIP1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 SIVA1 25361965 interaction type N/A PTMCode2
SIVA1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BCL2 25361965 interaction type N/A PTMCode2
BCL2 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CASP9 25361965 interaction type N/A PTMCode2
CASP9 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L11 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 SMC3 25361965 interaction type N/A PTMCode2
SMC3 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BECN1 25361965 interaction type N/A PTMCode2
BECN1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BNIP3 25361965 interaction type N/A PTMCode2
BNIP3 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 ABL1 25361965 interaction type N/A PTMCode2
ABL1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 CARD16 25361965 interaction type N/A PTMCode2
CARD16 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 IKZF3 25361965 interaction type N/A PTMCode2
IKZF3 BCL2L1 25361965 interaction type N/A PTMCode2
RAF1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 RAF1 25361965 interaction type N/A PTMCode2
BIK BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BIK 25361965 interaction type N/A PTMCode2
TP53 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 TP53 25361965 interaction type N/A PTMCode2
BCL2L10 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BCL2L10 25361965 interaction type N/A PTMCode2
BAX BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BAX 25361965 interaction type N/A PTMCode2
BAG1 BCL2L1 25361965 interaction type N/A PTMCode2
BCL2L1 BAG1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 BCL2L1 25348397 N/A physical interaction ComPPI
MAPK9 BCL2L1 25348397 N/A physical interaction ComPPI
BCL2L11 BCL2L1 10198631 11859372 14525934 14596824 16697956 17525735 24234451 25348397 9430630 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,scintillation proximity assay,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
FBP1 BCL2L1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1CC BCL2L1 25348397 N/A physical interaction,antibody array ComPPI
CRYAA BCL2L1 14525934 14752512 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CRYAB BCL2L1 14525934 14752512 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ACTB BCL2L1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP9 BCL2L1 14525934 24234451 25241761 25348397 9539746 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
BCL2L1 BAD 11483855 11494146 11583631 14525934 15131699 16697956 19427857 21988832 24234451 25241761 25348397 25416956 26871637 29997244 7834748 9305851 9388232 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo,luminescence based mammalian interactome mapping,proximity ligation assay,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
BCL2L1 BCAP31 14525934 24234451 25348397 9334338 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2L1 BAK1 11175750 14525934 14596824 15292519 15901672 16189514 19060904 24234451 25348397 29997244 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,scintillation proximity assay,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,luminescence based mammalian interactome mapping,two hybrid prey pooling approach ComPPI,HPRD,IntAct
BCL2L1 TMBIM6 14525934 25348397 9660918 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2L1 PSEN2 10446169 14525934 24234451 25348397 colocalization,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
BCL2L1 IRS2 10679027 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2L1 RTN1 11126360 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BCL2L1 BAG1 10467399 25348397 27898060 N/A in vivo ComPPI,OmniPath
BCL2L1 CASP8 11733517 14525934 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2L1 APAF1 12963020 14525934 25348397 9488720 9539746 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BCL2L1 BNIP1 10217402 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BCL2L1 BNIP3 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
BCL2L1 BIK 11342619 12853473 14525934 16189514 16697956 24234451 25348397 26871637 27107012 9525867 physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,surface plasmon resonance array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
BCL2L1 HRK 10075695 14525934 14596824 16697956 24234451 25348397 9130713 N/A experimental interaction detection,fluorescence polarization spectroscopy,scintillation proximity assay,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2L1 CFLAR 10197438 14525934 25348397 27898060 9326610 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
BCL2L1 BECN1 14525934 19180116 24234451 25348397 9765397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2L1 VDAC1 10365962 10737788 14525934 25348397 N/A anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L1 FKBP8 12510191 14525934 15733859 24234451 25348397 N/A two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2L1 AVEN 10949025 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BCL2L1 BCL2L14 11054413 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L1 IKZF3 11714801 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
BCL2L1 ANTXR1 11574549 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
BCL2L1 BCL2L10 11278245 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2L1 RTN4 11126360 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BCL2L1 SPNS1 12815463 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
BCL2L1 PMAIP1 10807576 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD
BCL2L1 PPP1CA 12115603 14525934 17274640 24234451 25348397 physical association experimental interaction detection,physical interaction,in vivo,antibody array ComPPI,HPRD,IntAct
BCL2L1 SIVA1 12011449 14525934 14739602 24234451 25348397 physical association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2L1 BCLAF1 10330179 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
BCL2L1 MOAP1 11060313 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BCL2L1 CAPN1 12000759 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCL2L1 RAD9A 10620799 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BCL2L1 BBC3 16697956 24234451 25348397 N/A two hybrid,fluorescence polarization spectroscopy,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
BCL2L1 BMF 14525934 15694340 16697956 24234451 25348397 25416956 26871637 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
BCL2L1 BCL2L12 11283018 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BCL2L1 BAX 11283018 14525934 15131699 17525735 24234451 25241761 25348397 9111042 9153240 9742125 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
BCL2L1 MAPK8 14525934 15733859 24234451 25241761 25348397 phosphorylation reaction,physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
BCL2L1 CYCS 14525934 24234451 25241761 25348397 9192670 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
BCL2L1 NLRP1 14525934 17418785 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2L1 MCL1 14525934 15077116 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L1 IRS1 10679027 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L1 PSEN1 10446169 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2L1 CASP1 14525934 25348397 27898060 9027312 9435230 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
BCL2L1 BCL2 11583631 14525934 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,HPRD
BCL2L1 SNCA 11742726 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BCL2L1 BID 14525934 15574335 15694340 16697956 24234451 25241761 25348397 physical association fluorescence polarization spectroscopy,isothermal titration calorimetry,physical interaction,proximity ligation assay,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
BCL2L1 BBC3 14525934 15574335 15694340 16697956 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BCL2L1 BNIPL 25348397 N/A physical interaction ComPPI
BCL2L1 RAF1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
BCL2L1 PGAM5 25348397 N/A physical interaction ComPPI
BCL2L1 BLID 20400521 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BCL2L1 UHRF2 21952639 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
BCL2L1 PARK7 25348397 N/A physical interaction ComPPI
BCL2L1 ZFYVE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 TP53 12667443 14525934 16151013 21900206 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,isothermal titration calorimetry,nuclear magnetic resonance,physical interaction ComPPI,HPRD,IntAct
BCL2L1 METTL23 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 PPHLN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 ZNF219 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 EDRF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 PDIA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 GLOD4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 RBM5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 PLD3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 DOCK7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 ZHX1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 UBR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 TP53BP2 21900206 24234451 25348397 physical association two hybrid,peptide array,physical interaction,surface plasmon resonance array ComPPI,IntAct
BCL2L1 LARP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 PTN 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 BFAR 25348397 N/A physical interaction ComPPI
BCL2L1 CLU 21527247 21567405 25348397 27898060 N/A anti bait coimmunoprecipitation,physical interaction ComPPI,OmniPath
BCL2L1 CRYAA2 25348397 N/A physical interaction ComPPI
BCL2L1 ATXN3 25348397 N/A physical interaction ComPPI
BCL2L1 AKT1 25348397 N/A physical interaction ComPPI
BCL2L1 PRKN 25348397 N/A physical interaction ComPPI
BCL2L1 PINK1 25348397 N/A physical interaction ComPPI
BCL2L1 TPT1 15870695 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BCL2L1 CDKN2A 25348397 N/A physical interaction ComPPI
BCL2L1 CDKN2A 25348397 N/A physical interaction ComPPI
BCL2L1 CASP8AP2 25348397 N/A physical interaction ComPPI
BCL2L1 MTOR 25348397 N/A anti bait coimmunoprecipitation,anti bait coimmunoprecipitation,phosphorylation reaction,physical interaction,physical interaction,protein kinase assay ComPPI
BCL2L1 GIMAP5 25348397 N/A physical interaction ComPPI
BCL2L1 ABL1 16631755 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2L1 ATG5 25348397 N/A physical interaction ComPPI
BCL2L1 PDS5A 25348397 N/A physical interaction ComPPI
BCL2L1 HNRNPA1 25348397 N/A physical interaction ComPPI
BCL2L1 BNIP3L 10467396 14525934 25348397 9973195 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BCL2L1 CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 USP14 25348397 25429837 26710889 27898060 N/A physical interaction ComPPI,OmniPath
BCL2L1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 PLK1 25348397 N/A physical interaction ComPPI
BCL2L1 GSK3A 25348397 N/A physical interaction ComPPI
BCL2L1 GSK3B 25348397 N/A physical interaction ComPPI
BCL2L1 MAPKAPK2 25348397 N/A physical interaction ComPPI
BCL2L1 MAPK14 25348397 N/A physical interaction ComPPI
BCL2L1 CDK1 25348397 N/A physical interaction ComPPI
BCL2L1 CHEK1 25348397 N/A physical interaction ComPPI
BCL2L1 AURKA 25348397 N/A physical interaction ComPPI
BCL2L1 USP18 25348397 N/A physical interaction ComPPI
BCL2L1 DNM1L 18250306 24234451 25348397 gtpase reaction anti tag coimmunoprecipitation,physical interaction,gtpase assay ComPPI,IntAct
BCL2L1 DYNLRB1 10198631 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BCL2L1 VRK2 25348397 N/A confocal microscopy ComPPI
BCL2L1 RTL10 25348397 N/A anti tag coimmunoprecipitation ComPPI
BCL2L1 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 TMEM50B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 MTIF3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 GORAB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 GNLY 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 BNIP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 GOLM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L1 PDPK1 25348397 N/A coimmunoprecipitation ComPPI
BLK BCL2L1 25348397 N/A physical interaction ComPPI
PLK3 BCL2L1 25348397 N/A physical interaction ComPPI
BCL2L1 BCL2L1 14525934 15131699 21856303 24234451 9130713 physical association cross-linking study,experimental interaction detection,blue native page,two hybrid HPRD,IntAct
BCL2L1 CED-4 24234451 9027313 physical association coimmunoprecipitation IntAct
UBC BCL2L1 12967636 22871113 27898060 N/A N/A OmniPath
BCL2L1 APAF1 10811864 12963020 27898060 9488720 9539746 inhibition,stimulant N/A OmniPath
MAPK9 BCL2L1 12633850 17369848 18794113 18974096 20363734 21840391 22617334 23953109 26188358 27898060 N/A N/A OmniPath
BID BCL2L1 15574335 15694340 15721256 16697956 22464442 24814347 25241761 27898060 9727492 inhibition N/A OmniPath
BCL2L1 BID 15574335 15694340 15721256 16697956 24814347 25241761 27898060 9873064 inhibition N/A OmniPath
BMF BCL2L1 11546872 15694340 15721256 16260615 16697956 25416956 27898060 inhibition N/A OmniPath
BCL2L1 CASP9 25241761 27898060 9539746 inhibition N/A OmniPath
PLK3 BCL2L1 21336504 21840391 27898060 stimulant N/A OmniPath
BNIP3 BCL2L1 10625696 27898060 inhibition N/A OmniPath
CAPN1 BCL2L1 12000759 27898060 inhibition N/A OmniPath
STAT5A BCL2L1 10652277 11085453 27898060 stimulant N/A OmniPath
SIVA1 BCL2L1 12011449 14739602 27898060 inhibition N/A OmniPath
BCL2L1 BAD 10620799 10949026 11077446 11206074 11483855 11494146 11583631 12115603 12137781 15131699 15694340 15705582 15721256 16697956 18628207 19427857 19667065 20603619 21988832 22705850 25241761 25416956 26186194 27898060 7834748 9305851 9388232 9389483 9824152 inhibition,stimulant N/A OmniPath
BAD BCL2L1 10620799 10949026 11077446 11206074 11483855 11494146 11583631 12115603 12137781 15131699 15694340 15705582 15721256 16697956 18628207 19427857 19667065 20603619 21988832 22705850 25241761 25416956 26186194 27898060 7834748 8929531 9305851 9372935 9388232 9389483 9824152 inhibition,stimulant N/A OmniPath
BCL2L1 BAK1 10085290 11175750 12137781 14596824 15292519 15901672 16189514 17289999 18178565 19060904 22705850 27898060 9463381 inhibition N/A OmniPath
BCL2L1 VDAC1 10365962 10737788 12767928 15637055 16189514 17209561 20080789 27898060 inhibition N/A OmniPath
JUNB BCL2L1 11163237 27898060 inhibition N/A OmniPath
CAPN2 BCL2L1 12000759 27898060 inhibition N/A OmniPath
TP53 BCL2L1 12667443 16151013 16455050 21900206 24474649 24814347 26556313 27898060 inhibition N/A OmniPath
BBC3 BCL2L1 15694340 27898060 inhibition N/A OmniPath
PMAIP1 BCL2L1 10807576 15694340 15721256 15725726 27898060 inhibition N/A OmniPath
CDKN2A BCL2L1 19049976 27898060 inhibition N/A OmniPath
BCL2L11 BCL2L1 10198631 11859372 14596824 15136728 15694340 15721256 16260615 16697956 18498746 19427863 26186194 27898060 9430630 9731710 inhibition N/A OmniPath
FUS BCL2L1 18471544 27898060 inhibition N/A OmniPath
CDK1 BCL2L1 19917720 27898060 N/A N/A OmniPath
SPNS1 BCL2L1 12815463 27898060 inhibition N/A OmniPath
BCL2L1 BECN1 17337444 17446862 17659302 18628207 18641390 19049976 19180116 19713971 22219388 24115198 27898060 9765397 inhibition,stimulant N/A OmniPath
BECN1 BCL2L1 17659302 18628207 18641390 19049976 19180116 19713971 22219388 24115198 27898060 9765397 N/A N/A OmniPath
BCL2L1 BIK 11342619 12853473 15694340 15721256 16189514 16697956 22705850 27898060 9305912 9525867 inhibition N/A OmniPath
BIK BCL2L1 11342619 12853473 15694340 15721256 16189514 16697956 22705850 27898060 7478623 9525867 inhibition N/A OmniPath
HRK BCL2L1 10075695 14596824 15721256 16697956 27898060 9130713 inhibition N/A OmniPath
BAX BCL2L1 11283018 12137781 12853473 14766748 15131699 19427863 21199865 21852238 22705850 25241761 26186194 26496610 27898060 7650488 8798452 9027312 9111042 9153240 9742125 9824152 N/A N/A OmniPath
BCL2L1 BAX 11283018 12137781 12853473 14766748 15131699 18178565 19427863 21199865 21852238 22705850 25241761 26186194 26496610 27898060 7650488 8596636 8798452 9027312 9111042 9153240 9670005 9742125 9824152 inhibition N/A OmniPath
ATG5 BCL2L1 16998475 27898060 N/A N/A OmniPath
STAT3 BCL2L1 11994401 27898060 stimulant N/A OmniPath
FKBP8 BCL2L1 12510191 15733859 27898060 stimulant N/A OmniPath
MAPK8 BCL2L1 10617621 12633850 15733859 18471544 25241761 27898060 inhibition N/A OmniPath
BCL2L1 MAPK8 15733859 25241761 27898060 N/A N/A OmniPath
BCL2L1 VDAC2 22705850 27898060 N/A N/A OmniPath
BBC3 BCL2L1 15574335 15694340 15721256 16697956 19074266 27898060 inhibition N/A OmniPath
BCAP31 BCL2L1 12594175 27898060 9334338 stimulant N/A OmniPath

Visualization










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