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GENE：DAPK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DAPK3
FullNmae death associated protein kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2676
EnsembleID ENSG00000167657
Uniprot O43293

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DAPK3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DAPK3 autophagy 40047320 In the study, it is confirmed that DBP can promote the expression of death-associated protein kinase 3 (DAPK3), thereby inducing autophagy of mouse Leydig cells by using in vivo and in vitro experiments. retulator signature
DAPK3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
DAPK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DAPK3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DAPK3 GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006355,GO:0006468,GO:0006915,GO:0006915,GO:0006940,GO:0007088,GO:0007346,GO:0008140,GO:0008360,GO:0010506,GO:0016605,GO:0017148,GO:0030335,GO:0031267,GO:0032956,GO:0032956,GO:0035556,GO:0035556,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043065,GO:0043519,GO:0043522,GO:0046777,GO:0046777,GO:0051893,GO:0071346,GO:0090263,GO:0097190,GO:0106310,GO:2000145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DAPK3 hsa:1613 path:hsa04140 Autophagy - animal - Homo sapiens (human)
DAPK3 hsa:1613 path:hsa05200 Pathways in cancer - Homo sapiens (human)
DAPK3 hsa:1613 path:hsa05219 Bladder cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DAPK3 STAT3 16219639 23180781 physical association anti tag coimmunoprecipitation InnateDB
DAPK3 RAD21 22145905 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
GRB14 DAPK3 20005715 interaction type N/A PSP
GRB14 DAPK3 12242277 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 DAPK3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DAPK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DAPK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DAPK3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DAPK3 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 DAPK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DAPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 DAPK3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA DAPK3 23622248 25416803 26117336 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clash TarBase
URS0000042E1F DAPK3 25416803 26117336 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
ROCK1 DAPK3 22135298 phosphorylation N/A PhosphoSite
DAPK3 PPP1R14A 22135298 phosphorylation N/A PhosphoSite
DAPK3 DAPK3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
DAPK3 MDM2 22135298 phosphorylation N/A PhosphoSite
DAPK3 RPL13A 22135298 phosphorylation N/A PhosphoSite
DAPK3 MYL12B 22135298 phosphorylation N/A PhosphoSite
DAPK3 TP53 22135298 phosphorylation N/A PhosphoSite
DAPK3 CDKN1A 22135298 phosphorylation N/A PhosphoSite
DAPK3 BECN1 22135298 phosphorylation N/A PhosphoSite
AATF DAPK3 25361965 interaction type N/A PTMCode2
DAPK3 AATF 25361965 interaction type N/A PTMCode2
DAPK3 PAWR 25361965 interaction type N/A PTMCode2
PAWR DAPK3 25361965 interaction type N/A PTMCode2
DAPK3 ATF4 25361965 interaction type N/A PTMCode2
ATF4 DAPK3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DAXX DAPK3 12917339 24234451 25348397 physical association coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
CDKN1A DAPK3 14525934 15001356 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ATF4 DAPK3 14525934 21408167 24234451 25348397 9488481 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
PPP1CB DAPK3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD21 DAPK3 25348397 N/A physical interaction ComPPI
HSP90AB1 DAPK3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NLK DAPK3 21454679 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GRB2 DAPK3 12577067 24234451 25348397 association pull down ComPPI,IntAct
AR DAPK3 25348397 N/A physical interaction ComPPI
FLNA DAPK3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R12A DAPK3 15292222 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
HSP90AA1 DAPK3 25348397 N/A physical interaction ComPPI
GRB14 DAPK3 25348397 N/A physical interaction ComPPI
IQGAP1 DAPK3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCZ DAPK3 12242277 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DAPK3 MET 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DAPK3 PAWR 10602480 12917339 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DAPK3 UBE2D3 18515077 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DAPK3 MDM2 25348397 N/A physical interaction ComPPI
DAPK3 TP53 25348397 N/A physical interaction ComPPI
DAPK3 CHEK2 25348397 N/A physical interaction ComPPI
DAPK3 HSP90AA2P 25348397 N/A physical interaction ComPPI
DAPK3 AK3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DAPK3 TCP10L 15910542 21988832 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
DAPK3 RPL34 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DAPK3 TSG101 25348397 N/A physical interaction ComPPI
DAPK3 ULK1 25348397 N/A physical interaction ComPPI
DAPK3 CEP170 25348397 N/A physical interaction ComPPI
DAPK3 GPS2 25348397 N/A physical interaction ComPPI
DAPK3 PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DAPK3 CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DAPK3 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DAPK3 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DAPK3 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DAPK3 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 CDK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 MYO5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 MYO18A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 CDC14A 25348397 N/A physical interaction ComPPI
DAPK3 KIF2B 25348397 N/A physical interaction ComPPI
DAPK3 MEAF6 25348397 N/A physical interaction ComPPI
DAPK3 TNFRSF8 25348397 N/A physical interaction ComPPI
DAPK3 KLHDC3 25348397 N/A physical interaction ComPPI
DAPK3 CDC37 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DAPK3 STAT3 16219639 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DAPK3 MYL12B 21487036 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
DAPK3 RHOD 23454120 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
AATF DAPK3 10580117 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NEDD4L DAPK3 25348397 N/A physical interaction ComPPI
DAPK3 DAPK3 14525934 18239682 21487036 24234451 9488481 physical association anti tag coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,x-ray crystallography HPRD,IntAct
ENPP3 DAPK3 24234451 30021884 physical association cross-linking study IntAct
CSTF3 DAPK3 24234451 30021884 physical association cross-linking study IntAct
DAPK3 CDKN1A 15001356 27898060 stimulant N/A OmniPath
ROCK1 DAPK3 15611134 16325270 17158456 18239682 27898060 stimulant N/A OmniPath
DAPK3 MYL9 10356987 11384979 15096528 19851336 2526655 27898060 stimulant N/A OmniPath
DAPK3 MDM2 12167711 15001356 23146908 27898060 stimulant N/A OmniPath
ULK1 DAPK3 21169990 27898060 stimulant N/A OmniPath
DAPK3 MYL5 11384979 27898060 stimulant N/A OmniPath
DAPK3 PPP1R12A 11226254 15292222 27898060 inhibition N/A OmniPath
DAPK3 H3C1 11278789 12560483 27898060 N/A N/A OmniPath
DAPK3 TP53 17339337 27898060 stimulant N/A OmniPath
DAPK3 RPL13A 18995835 27898060 inhibition,stimulant N/A OmniPath
DAPK3 CCNH 12140753 27898060 N/A N/A OmniPath
DAPK3 AR 18084323 27898060 stimulant N/A OmniPath
DAPK1 DAPK3 15367680 15611134 27898060 stimulant N/A OmniPath
STAT3 DAPK3 16219639 27898060 N/A N/A OmniPath
DAPK3 NR3C1 18084323 27898060 stimulant N/A OmniPath
DAPK3 MYL12A 10356987 11781833 15096528 27898060 stimulant N/A OmniPath
DAPK3 PPP1R14A 11287002 12144526 12495628 12604330 12804574 15003508 15184667 16472257 23541585 27898060 stimulant N/A OmniPath
DAPK3 MYL12B 1178183 11942626 12429016 15946647 21487036 27898060 stimulant N/A OmniPath

Visualization










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