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GENE：EEF1A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EEF1A2
FullNmae eukaryotic translation elongation factor 1 alpha 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3192
EnsembleID ENSG00000101210
Uniprot Q05639

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EEF1A2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EEF1A2 autophagy 32275913 These results suggest that eEF1A2 is essential for dopaminergic neuron survival against MPP+, in part through autophagy regulation. retulator signature
EEF1A2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EEF1A2 GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005853,GO:0006412,GO:0006414,GO:0008135,GO:0019901,GO:0043065,GO:0045202,GO:0090218,GO:0098574,GO:1904714

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EEF1A2 hsa:1917 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
EEF1A2 hsa:1917 path:hsa05134 Legionellosis - Homo sapiens (human)
EEF1A2 hsa:1917 path:hsa05140 Leishmaniasis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YWHAE EEF1A2 20462248 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 EEF1A2 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 EEF1A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EEF1A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EEF1A2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF EEF1A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EEF1A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EEF1A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EEF1A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EEF1A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 EEF1A2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000F31F4 EEF1A2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 EEF1A2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000148B91 EEF1A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004929F1 EEF1A2 23695020 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EC1BE EEF1A2 23695020 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000321A1A EEF1A2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000075C3F6 EEF1A2 25416803 25744894 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
RAF1 EEF1A2 22135298 phosphorylation N/A PhosphoSite
MAPK8 EEF1A2 22135298 phosphorylation N/A PhosphoSite
BRAF EEF1A2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 EEF1A2 25348397 N/A physical interaction ComPPI
CUL5 EEF1A2 25348397 N/A physical interaction ComPPI
CKS1B EEF1A2 25348397 N/A physical interaction ComPPI
ZNF490 EEF1A2 25348397 N/A physical interaction ComPPI
ISG15 EEF1A2 25348397 N/A physical interaction ComPPI
ACTG1 EEF1A2 25348397 N/A physical interaction ComPPI
TRAF6 EEF1A2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VCP EEF1A2 25348397 N/A physical interaction ComPPI
MCM5 EEF1A2 25348397 N/A physical interaction ComPPI
GABARAPL2 EEF1A2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTB EEF1A2 25348397 N/A physical interaction ComPPI
DCUN1D1 EEF1A2 25348397 N/A physical interaction ComPPI
MCM2 EEF1A2 25348397 N/A physical interaction ComPPI
MAP1LC3B EEF1A2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
C4ORF19 EEF1A2 25348397 N/A physical interaction ComPPI
SREK1IP1 EEF1A2 25348397 N/A physical interaction ComPPI
RPA1 EEF1A2 25348397 N/A physical interaction ComPPI
MAPK6 EEF1A2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKM EEF1A2 25348397 N/A physical interaction ComPPI
SEM1 EEF1A2 25348397 N/A physical interaction ComPPI
POLR1A EEF1A2 25348397 N/A physical interaction ComPPI
EEF1D EEF1A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1B2 EEF1A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A2 CHRM4 12048193 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EEF1A2 VARS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A2 MGMT 25348397 N/A physical interaction ComPPI
EEF1A2 SRRM2 25348397 N/A physical interaction ComPPI
EEF1A2 PTEN 25348397 N/A physical interaction ComPPI
EEF1A2 ARRB1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A2 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A2 TCF3 25348397 N/A physical interaction ComPPI
EEF1A2 FBXO25 25348397 N/A physical interaction ComPPI
EEF1A2 NFX1 25348397 N/A physical interaction ComPPI
EEF1A2 CUL3 25348397 N/A physical interaction ComPPI
EEF1A2 CUL4A 25348397 N/A physical interaction ComPPI
EEF1A2 CUL4B 25348397 N/A physical interaction ComPPI
EEF1A2 CUL2 25348397 N/A physical interaction ComPPI
EEF1A2 CUL1 25348397 N/A physical interaction ComPPI
EEF1A2 COPS5 25348397 N/A physical interaction ComPPI
EEF1A2 COPS6 25348397 N/A physical interaction ComPPI
EEF1A2 CAND1 25348397 N/A physical interaction ComPPI
EEF1A2 NEDD8 18274552 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EEF1A2 UBXN6 25348397 N/A physical interaction ComPPI
EEF1A2 TTLL12 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EEF1A2 YWHAE 25348397 N/A physical interaction ComPPI
EEF1A2 BTK 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
EEF1A2 CD81 25348397 N/A physical interaction ComPPI
EEF1A2 IGSF8 25348397 N/A physical interaction ComPPI
EEF1A2 CDK3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EEF1A2 PRKN 25348397 N/A physical interaction ComPPI
EEF1A2 AHCY 25348397 N/A physical interaction ComPPI
EEF1A2 SEM1 25348397 N/A physical interaction ComPPI
EEF1A2 RPA3 25348397 N/A physical interaction ComPPI
EEF1A2 RPA2 25348397 N/A physical interaction ComPPI
EEF1A2 ERG 25348397 N/A physical interaction ComPPI
EEF1A2 TRIM25 25348397 N/A physical interaction ComPPI
EEF1A2 LGR4 25348397 N/A physical interaction ComPPI
EEF1A2 UBC 25348397 N/A physical interaction ComPPI
EEF1A2 AURKA 25348397 N/A physical interaction ComPPI
EEF1A2 CEP57 25348397 N/A physical interaction ComPPI
EEF1A2 HAUS2 25348397 N/A physical interaction ComPPI
EEF1A2 CEP76 25348397 N/A physical interaction ComPPI
EEF1A2 TUBG1 25348397 N/A physical interaction ComPPI
EEF1A2 ABTB1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EEF1A2 PBDC1 25348397 N/A physical interaction ComPPI
EEF1A2 NXPH2 25348397 N/A physical interaction ComPPI
EEF1A2 NUFIP1 25348397 N/A physical interaction ComPPI
EEF1A2 DGUOK 25348397 N/A physical interaction ComPPI
EEF1A2 HEXIM1 25348397 N/A physical interaction ComPPI
EEF1A2 HOMER1 25348397 N/A physical interaction ComPPI
EEF1A2 TMEM25 25348397 N/A physical interaction ComPPI
EEF1A2 WDR53 25348397 N/A physical interaction ComPPI
EEF1A2 DCP2 25348397 N/A physical interaction ComPPI
EEF1A2 DDHD2 25348397 N/A physical interaction ComPPI
EEF1A2 GJA1 25348397 N/A physical interaction ComPPI
EEF1A2 RNF26 25348397 N/A physical interaction ComPPI
EEF1A2 EEF1G 25348397 N/A physical interaction ComPPI
EEF1A2 FAM177A1 25348397 N/A physical interaction ComPPI
EEF1A2 PLK2 25348397 N/A physical interaction ComPPI
EEF1A2 CDK7 25348397 N/A physical interaction ComPPI
EEF1A2 EEF2 25348397 N/A physical interaction ComPPI
EEF1A2 EFTUD2 25348397 N/A physical interaction ComPPI
EEF1A2 GMPPB 25348397 N/A physical interaction ComPPI
EEF1A2 GORASP2 25348397 N/A physical interaction ComPPI
EEF1A2 PABPC1 25348397 N/A physical interaction ComPPI
EEF1A2 PABPC3 25348397 N/A physical interaction ComPPI
EEF1A2 PKLR 25348397 N/A physical interaction ComPPI
EEF1A2 POLR2A 25348397 N/A physical interaction ComPPI
EEF1A2 PSMD1 25348397 N/A physical interaction ComPPI
EEF1A2 RPL12 25348397 N/A physical interaction ComPPI
EEF1A2 RPL30 25348397 N/A physical interaction ComPPI
EEF1A2 RPL4 25348397 N/A physical interaction ComPPI
EEF1A2 RPSA 25348397 N/A physical interaction ComPPI
EEF1A2 STK11 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EEF1A2 ID2 25348397 N/A physical interaction ComPPI
EEF1A2 CRY2 25348397 N/A physical interaction ComPPI
EEF1A2 ESRRB 25348397 N/A physical interaction ComPPI
EEF1A2 CDC37 25348397 N/A physical interaction ComPPI
EEF1A2 DPF3 25348397 N/A physical interaction ComPPI
EEF1A2 WWP2 25348397 N/A physical interaction ComPPI
EEF1A2 EEF1A1 25348397 N/A physical interaction ComPPI
EEF1A2 EEF1A1P5 25348397 N/A physical interaction ComPPI
EEF1A2 EEF1AKMT1 25348397 N/A physical interaction ComPPI
EEF1A2 CARS1 25348397 N/A physical interaction ComPPI
EEF1A2 PSG1 25348397 N/A physical interaction ComPPI
EEF1A2 IL36A 25348397 N/A physical interaction ComPPI
EEF1A2 FGB 25348397 N/A physical interaction ComPPI
EEF1A2 PITHD1 25348397 N/A physical interaction ComPPI
EEF1A2 RAB1A 25348397 N/A physical interaction ComPPI
EEF1A2 GTF2E2 25348397 N/A physical interaction ComPPI
EEF1A2 MIA2 25348397 N/A physical interaction ComPPI
EEF1A2 GYPA 25348397 N/A physical interaction ComPPI
EEF1A2 LRRC56 25348397 N/A physical interaction ComPPI
EEF1A2 MLLT6 25348397 N/A physical interaction ComPPI
EEF1A2 FUOM 25348397 N/A physical interaction ComPPI
EEF1A2 TPT1 25348397 N/A physical interaction ComPPI
EEF1A2 NCSTN 25348397 N/A physical interaction ComPPI
EEF1A2 HSPB8 25348397 N/A physical interaction ComPPI
EEF1A2 GJB7 25348397 N/A physical interaction ComPPI
EEF1A2 SLC38A7 25348397 N/A physical interaction ComPPI
EEF1A2 SLC13A5 25348397 N/A physical interaction ComPPI
EEF1A2 TBXAS1 25348397 N/A physical interaction ComPPI
EEF1A2 BTNL3 25348397 N/A physical interaction ComPPI
EEF1A2 RPS11 25348397 N/A physical interaction ComPPI
EEF1A2 PPIAL4G 25348397 N/A physical interaction ComPPI
EEF1A2 DHX57 25348397 N/A physical interaction ComPPI
EEF1A2 ST6GALNAC1 25348397 N/A physical interaction ComPPI
EEF1A2 USP47 25348397 N/A physical interaction ComPPI
EEF1A2 TLE3 25348397 N/A physical interaction ComPPI
EEF1A2 DBF4 25348397 N/A physical interaction ComPPI
EEF1A2 FLT4 25348397 N/A physical interaction ComPPI
EEF1A2 CYLD 25348397 N/A physical interaction ComPPI
EEF1A2 MTF1 25348397 N/A physical interaction ComPPI
EEF1A2 HNRNPL 25348397 N/A physical interaction ComPPI
EEF1A2 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 CHUK 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 NFKB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 RELA 25348397 N/A tandem affinity purification ComPPI
EEF1A2 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 TAB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 TRADD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 TRAF2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
EEF1A2 PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A2 ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
EEF1A2 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A2 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EEF1A2 LRRK2 19559761 24234451 25348397 27898060 physical association protein kinase assay ComPPI,IntAct,OmniPath
EEF1A2 STK4 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SNRNP27 EEF1A2 25348397 N/A physical interaction ComPPI
TSPY1 EEF1A2 14525934 18649364 N/A experimental interaction detection HPRD
METTL14 EEF1A2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
MAPT EEF1A2 24234451 26402096 association anti bait coimmunoprecipitation IntAct
ISG15 EEF1A2 16009940 27898060 N/A N/A OmniPath
CHRM4 EEF1A2 12048193 27898060 stimulant N/A OmniPath

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