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GENE：ERN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERN1
FullNmae endoplasmic reticulum to nucleus signaling 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3449
EnsembleID ENSG00000178607
Uniprot O75460

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERN1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERN1 autophagy 22874569 Silencing of ERN1 (IRE1α) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing. retulator signature
ERN1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ERN1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERN1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ERN1 GO:0000287,GO:0001935,GO:0004521,GO:0004521,GO:0004674,GO:0004674,GO:0005161,GO:0005515,GO:0005524,GO:0005637,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005789,GO:0006402,GO:0006468,GO:0016241,GO:0019899,GO:0030544,GO:0033120,GO:0034620,GO:0034620,GO:0034976,GO:0035924,GO:0036289,GO:0036498,GO:0036498,GO:0036498,GO:0042802,GO:0042803,GO:0042803,GO:0042803,GO:0043507,GO:0043531,GO:0046777,GO:0051082,GO:0051879,GO:0070054,GO:0070054,GO:0070054,GO:0070059,GO:0070059,GO:0070301,GO:0071333,GO:0106310,GO:1900103,GO:1901142,GO:1904707,GO:1990332,GO:1990579,GO:1990597,GO:1990604,GO:1990604,GO:1990630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERN1 hsa:2081 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ERN1 hsa:2081 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
ERN1 hsa:2081 path:hsa04210 Apoptosis - Homo sapiens (human)
ERN1 hsa:2081 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05012 Parkinson disease - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05016 Huntington disease - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ERN1 hsa:2081 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAF2 ERN1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 ERN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ERN1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ERN1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ERN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 ERN1 20513357 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000047E28E ERN1 23598528 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000B59A2 ERN1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF ERN1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 ERN1 22100165 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ERN1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE ERN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA ERN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 ERN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 ERN1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A ERN1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 ERN1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 ERN1 23313552 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C ERN1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB ERN1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000157F5 ERN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D ERN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000334286 ERN1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERN1 ERN1 22135298 phosphorylation N/A PhosphoSite
TAOK3 ERN1 25361965 interaction type N/A PTMCode2
ERN1 TAOK3 25361965 interaction type N/A PTMCode2
BAX ERN1 25361965 interaction type N/A PTMCode2
ERN1 BAX 25361965 interaction type N/A PTMCode2
TNFRSF1A ERN1 25361965 interaction type N/A PTMCode2
ERN1 TNFRSF1A 25361965 interaction type N/A PTMCode2
MAP3K5 ERN1 25361965 interaction type N/A PTMCode2
ERN1 MAP3K5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 ERN1 25348397 N/A physical interaction ComPPI
COPS5 ERN1 14525934 15234121 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
UBB ERN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC ERN1 18369366 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS27A ERN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 ERN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HSP90AA1 ERN1 12446770 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSPA5 ERN1 12637535 14525934 24234451 25348397 27238082 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HSPA1A ERN1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
HSPA1B ERN1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
MAP3K5 ERN1 12050113 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
TNFRSF1A ERN1 14525934 16680093 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
SYVN1 ERN1 14525934 18369366 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRAF2 ERN1 10650002 11278723 12843613 14525934 24234451 25241761 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
RIPK1 ERN1 25348397 N/A physical interaction ComPPI
UCHL1 ERN1 25348397 N/A physical interaction ComPPI
BAK1 ERN1 14525934 16645094 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BAX ERN1 14525934 16645094 24234451 25348397 N/A experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
OS9 ERN1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SRPK2 ERN1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
DERL1 ERN1 25348397 N/A physical interaction ComPPI
STUB1 ERN1 25348397 N/A physical interaction ComPPI
ERN1 TAOK3 11278723 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ERN1 PSEN1 10587643 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ERN1 HSP90AA2P 25348397 N/A physical interaction ComPPI
ERN1 USP14 25348397 N/A physical interaction ComPPI
ERN1 DERL3 25348397 N/A physical interaction ComPPI
ERN1 SEL1L 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
ERN1 RNF13 25348397 N/A physical interaction ComPPI
ERN1 OTUB1 25348397 N/A physical interaction ComPPI
ERN1 FBXO11 25348397 N/A physical interaction ComPPI
ERN1 TP53 25348397 N/A physical interaction ComPPI
ERN1 NTAQ1 25348397 N/A physical interaction ComPPI
ERN1 SCGB2A2 25348397 N/A physical interaction ComPPI
ERN1 LYPD4 25348397 N/A physical interaction ComPPI
ERN1 ZNRF4 25348397 N/A physical interaction ComPPI
ERN1 YIPF5 24234451 25348397 25742138 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct,OmniPath
ERN1 SEC24C 24234451 25348397 25742138 association anti bait coimmunoprecipitation ComPPI,IntAct
ERN1 SEC24A 24234451 25348397 25742138 association anti bait coimmunoprecipitation ComPPI,IntAct
ERN1 SEC24D 24234451 25348397 25742138 association anti bait coimmunoprecipitation ComPPI,IntAct
ERN1 SEC24B 24234451 25348397 25742138 association anti bait coimmunoprecipitation ComPPI,IntAct
ERN1 ERN1 12637535 14525934 21317875 24234451 physical association experimental interaction detection,x-ray crystallography,comigration in non denaturing gel electrophoresis HPRD,IntAct
ERN1 KAT2A 27898060 9113982 N/A N/A OmniPath
ERN1 TNFRSF10D 16990850 27898060 N/A N/A OmniPath
PRC1 ERN1 21775630 21852455 27898060 N/A N/A OmniPath
HSPA5 ERN1 12637535 18624755 21118962 27898060 inhibition N/A OmniPath
ERN1 XBP1 18471544 27898060 stimulant N/A OmniPath
ERN1 MAPK8 18471544 27898060 stimulant N/A OmniPath
DAB2IP ERN1 27858941 27898060 stimulant N/A OmniPath

Visualization










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