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GENE：GFAP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GFAP
FullNmae glial fibrillary acidic protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4235
EnsembleID ENSG00000131095
Uniprot P14136

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GFAP autophagy 18414043 The activation of p38 MAPK by GFAP accumulation is responsible for mTOR inactivation and the induction of autophagy. retulator signature
GFAP autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GFAP GO:0005178,GO:0005200,GO:0005515,GO:0005737,GO:0005737,GO:0005764,GO:0005829,GO:0005882,GO:0006886,GO:0010467,GO:0010625,GO:0010977,GO:0014002,GO:0014010,GO:0019900,GO:0030198,GO:0031102,GO:0042802,GO:0042995,GO:0043254,GO:0044297,GO:0045109,GO:0045109,GO:0045111,GO:0051580,GO:0060020,GO:0060291,GO:0070779,GO:0097450,GO:0098574,GO:1904714,GO:1904714,GO:1904714

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GFAP hsa:2670 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP GFAP 16049941 21832049 23180781 physical association anti tag coimmunoprecipitation,protein array InnateDB
TLE5 GFAP 23180781 25416956 physical association two hybrid InnateDB
BIRC2 GFAP 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR GFAP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TBP GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GFAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EP300 GFAP 20414733 trascriptional regulation,stimulation inferred by curator TFlink
NFIC GFAP 19540848 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 GFAP 16516312 20471977 trascriptional regulation,stimulation inferred by curator TFlink
RELA GFAP 16516312 20471977 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 GFAP 11740937 21833841 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A GFAP N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GFAP 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA GFAP 22135298 phosphorylation N/A PhosphoSite
ROCK1 GFAP 22135298 phosphorylation N/A PhosphoSite
AURKB GFAP 22135298 phosphorylation N/A PhosphoSite
GFAP APP 25361965 interaction type N/A PTMCode2
APP GFAP 25361965 interaction type N/A PTMCode2
GFAP S100B 25361965 interaction type N/A PTMCode2
S100B GFAP 25361965 interaction type N/A PTMCode2
GFAP MEN1 25361965 interaction type N/A PTMCode2
MEN1 GFAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D22B GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LENG1 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GOLGA2 GFAP 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MOS GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF774 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FAM50B GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAPK9 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT19 GFAP 24234451 25348397 25910212 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
DES GFAP 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CFAP206 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
YES1 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA8 GFAP 25348397 N/A physical interaction ComPPI
UBASH3A GFAP 25348397 N/A two hybrid ComPPI
UBASH3B GFAP 25348397 N/A physical interaction ComPPI
EPM2AIP1 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CRYAB GFAP 25348397 N/A physical interaction ComPPI
S100B GFAP 10510252 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VIM GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A1 GFAP 10510252 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STAT1 GFAP 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GABARAPL2 GFAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ROCK1 GFAP 14525934 2114109 2155236 25348397 7822264 9099667 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP1LC3B GFAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KRT31 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDIT4L GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ERRFI1 GFAP 25348397 N/A physical interaction ComPPI
PRKCA GFAP 14525934 2114109 2155236 25348397 7822264 9099667 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC GFAP 11379820 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRAP2 GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SHC1 GFAP 25348397 N/A physical interaction ComPPI
GRB2 GFAP 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD2 GFAP 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKACA GFAP 14525934 2114109 2155236 25348397 7822264 9099667 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HGS GFAP 25348397 N/A physical interaction ComPPI
HSPA5 GFAP 25348397 N/A physical interaction ComPPI
NEFM GFAP 25348397 N/A physical interaction ComPPI
PDLIM7 GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HMGB1 GFAP 25348397 N/A physical interaction ComPPI
PRKCG GFAP 25348397 N/A physical interaction ComPPI
UBR2 GFAP 25348397 N/A physical interaction ComPPI
SMARCB1 GFAP 25348397 N/A physical interaction ComPPI
LMO2 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PDZK1 GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSEN2 GFAP 25348397 N/A physical interaction ComPPI
HTT GFAP 17500595 24234451 25348397 association pull down ComPPI,IntAct
SKP2 GFAP 25348397 N/A physical interaction ComPPI
TLE5 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PDLIM1 GFAP 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GABARAP GFAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A GFAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DNM1L GFAP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CDC37 GFAP 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFIP11 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AP2M1 GFAP 25348397 N/A physical interaction ComPPI
BIRC2 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RORA GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PDCD6IP GFAP 25348397 N/A physical interaction ComPPI
ESR2 GFAP 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
SYNC GFAP 25348397 N/A physical interaction ComPPI
TRIM27 GFAP 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
AKT1 GFAP 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
INA GFAP 25348397 N/A physical interaction ComPPI
ESRRB GFAP 25348397 N/A physical interaction ComPPI
AURKB GFAP 25348397 N/A physical interaction ComPPI
NES GFAP 25348397 N/A physical interaction ComPPI
CARD10 GFAP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CEBPA GFAP 25348397 N/A physical interaction ComPPI
TARDBP GFAP 25348397 N/A physical interaction ComPPI
USP10 GFAP 25348397 N/A physical interaction ComPPI
HEATR1 GFAP 25348397 N/A physical interaction ComPPI
TUBGCP4 GFAP 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GFAP POM121 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GFAP RIBC2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
GFAP CEP76 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GFAP KIAA0408 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GFAP MEN1 12169273 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GFAP PSEN1 12058025 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
GFAP SH3YL1 14525934 16189514 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
GFAP PDZK1P1 25348397 N/A physical interaction ComPPI
GFAP MYO15B 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach ComPPI,IntAct
GFAP FBXO25 25348397 N/A physical interaction ComPPI
GFAP APP 16049941 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GFAP ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GFAP IKBKG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GFAP GFAP 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP KRT13 24234451 25348397 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP KRT15 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP NXF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP LGALS14 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP ZC2HC1C 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP PIH1D2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GFAP NT5DC1 25348397 N/A physical interaction ComPPI
GFAP DNASE1L1 25348397 N/A physical interaction ComPPI
GFAP P2RY8 25348397 N/A physical interaction ComPPI
GFAP ALG3 25348397 N/A physical interaction ComPPI
GFAP UBE3A 25348397 N/A physical interaction ComPPI
GFAP ERBB3 25348397 N/A physical interaction ComPPI
GFAP ATOH1 25348397 N/A physical interaction ComPPI
GFAP RSPRY1 25348397 N/A physical interaction ComPPI
GFAP UBR1 25348397 N/A physical interaction ComPPI
GFAP CLEC4M 25348397 N/A physical interaction ComPPI
GFAP DNAH14 25348397 N/A physical interaction ComPPI
GFAP TEKT2 25348397 N/A physical interaction ComPPI
GFAP DIPK2A 25348397 N/A physical interaction ComPPI
GFAP CDK1 12177195 14525934 24234451 25348397 29128334 7822264 association cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
GFAP SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GFAP COL16A1 18804107 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
GFAP GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GFAP PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GFAP TBC1D21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP MYBPHL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP PPP1R16B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP KRT39 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP PPP1R18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP NFKBID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP CWF19L2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP CT55 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP ZNF655 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP KRT27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GFAP COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
NEFL GFAP 24234451 25348397 26871637 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TPT1 GFAP 24234451 27607350 association anti bait coimmunoprecipitation IntAct
PRKACA GFAP 2114109 2155236 27898060 7822264 9099667 N/A N/A OmniPath
PRKCA GFAP 2114109 2155236 27898060 7822264 9099667 N/A N/A OmniPath
AURKB GFAP 11918673 12177195 12686604 19170683 2155236 27898060 7822264 8647894 9099667 N/A N/A OmniPath
ROCK1 GFAP 12686604 2114109 2155236 27898060 7822264 9099667 N/A N/A OmniPath
CDK1 GFAP 12177195 27898060 7822264 stimulant N/A OmniPath
GSK3B GFAP 12177195 12686604 2155236 27898060 7822264 N/A N/A OmniPath

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