GENE：HGF
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HGF |
| FullNmae | hepatocyte growth factor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4893 |
| EnsembleID | ENSG00000019991 |
| Uniprot | P14210 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HGF | pyroptosis | 32795289 | The protective effect of HGF against pyroptosis was dependent on c-Met/mTOR signalling. | retulator signature |
| HGF | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HGF | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HGF | autophagy | 33639217 | Conversely, HGF overexpression efficiently increased the p-met and autophagy levels and strengthened the protective effects of SEV. | retulator signature |
| HGF | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| HGF | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HGF | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HGF | GO:0000278,GO:0000902,GO:0001837,GO:0001889,GO:0001934,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0008083,GO:0010507,GO:0014856,GO:0016020,GO:0030335,GO:0031093,GO:0032715,GO:0032733,GO:0033137,GO:0035729,GO:0042056,GO:0042802,GO:0043066,GO:0043154,GO:0043410,GO:0045669,GO:0045944,GO:0048012,GO:0048012,GO:0050673,GO:0050728,GO:0050731,GO:0050918,GO:0051450,GO:0051897,GO:0060326,GO:0060665,GO:0090201,GO:1900744,GO:1901299,GO:1902042,GO:2000573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HGF | hsa:3082 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05144 | Malaria - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| HGF | hsa:3082 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HGF | ACTA2 | 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26192618 26366398 26819959 27474009 28475121 9242465 | interaction type | N/A | ACSN |
| HGF | FAP | 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26192618 26366398 26819959 27474009 28475121 9242465 | interaction type | N/A | ACSN |
| HGF | CXCL12 | 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26192618 26366398 26819959 27474009 28475121 9242465 | interaction type | N/A | ACSN |
| FGF1 | HGF | 14517404 16272825 16682805 26183471 26192618 9242465 | interaction type | N/A | ACSN |
| FGF4 | HGF | 26192618 9242465 | interaction type | N/A | ACSN |
| FGF2 | HGF | 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 26192618 9242465 | interaction type | N/A | ACSN |
| HGF | MET | 23331499 8380735 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | HGF | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | HGF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | HGF | 10860846 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | HGF | 9223667 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | HGF | 9223667 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | HGF | 9223667 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | HGF | 12168776 23954444 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | HGF | 10860846 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | HGF | 25416803 28393839 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000008DA94 | HGF | 25416803 27374174 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HGF | SDC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SDC1 | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | CLEC3B | 25361965 | interaction type | N/A | PTMCode2 |
| CLEC3B | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | MST1R | 25361965 | interaction type | N/A | PTMCode2 |
| MST1R | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | SDC2 | 25361965 | interaction type | N/A | PTMCode2 |
| SDC2 | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | HRAS | 25361965 | interaction type | N/A | PTMCode2 |
| HRAS | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | MET | 25361965 | interaction type | N/A | PTMCode2 |
| MET | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| HGF | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | HGF | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MEOX2 | HGF | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CD44 | HGF | 22897854 24234451 25348397 | physical association | cross-linking study | ComPPI,IntAct |
| SDC2 | HGF | 14525934 25348397 27898060 8157651 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| CLEC3B | HGF | 12694198 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| VTN | HGF | 14525934 15717924 25348397 | N/A | experimental interaction detection,enzyme linked immunosorbent assay,in vitro | ComPPI,HPRD |
| HGFAC | HGF | 14525934 20004165 24234451 25348397 8631970 | cleavage reaction | experimental interaction detection,cleavage reaction,protease assay,in vitro | ComPPI,HPRD,IntAct |
| F11 | HGF | 10962009 12372819 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MET | HGF | 14525934 15167892 16537482 1655405 17804794 17981115 1846706 18495663 24234451 25348397 | physical association | cross-linking study,experimental interaction detection,fluorescent resonance energy transfer,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,x ray scattering,amplified luminescent proximity homogeneous assay | ComPPI,HPRD,IntAct |
| SDC1 | HGF | 11830493 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| ST14 | HGF | 10962009 12372819 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| VWF | HGF | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| KLKB1 | HGF | 10962009 12372819 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| HSPG2 | HGF | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| BRCA1 | HGF | 25348397 | N/A | physical interaction | ComPPI |
| DSP | HGF | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| HGF | HPN | 14525934 15792801 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| HGF | LCN2 | 14525934 15637066 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| HGF | FN1 | 14525934 15717924 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,proximity ligation assay | ComPPI,HPRD,IntAct |
| HGF | TNC | 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI |
| HGF | ADAMTSL4 | 25348397 | N/A | physical interaction | ComPPI |
| HGF | FKBP7 | 25348397 | N/A | physical interaction | ComPPI |
| HGF | SRPX2 | 22242148 24234451 25348397 27898060 | N/A | biosensor | ComPPI,IntAct,OmniPath |
| HGF | HGF | 11597998 12051906 14525934 17804794 20624990 24234451 9817840 9886295 | N/A | experimental interaction detection,x-ray crystallography | HPRD,IntAct |
| HGF | PLAU | 1334458 14525934 | N/A | experimental interaction detection | HPRD |
| TP53 | HGF | 18431400 27898060 | stimulant | N/A | OmniPath |
| HGF | MET | 14685170 15167892 16537482 1655405 17145710 17804794 17981115 1846706 18495663 19433454 20624990 27898060 8380735 | stimulant | N/A | OmniPath |
| HGF | CD44 | 10037743 27898060 | N/A | N/A | OmniPath |