Gene Information gene info

  1. Home

GENE：IL6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL6
FullNmae interleukin 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6018
EnsembleID ENSG00000136244
Uniprot P05231

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL6 pyroptosis 38107476 While others may exacerbate the condition, such as IL-6, IL-7, IL-15, IL-33, myostatin, fractalkine, follistatin-like 1 (FSTL1), visfatin, activin A, migration inhibitory factor (MIF), apelin and growth differentiation factor (GDF)-15. They exerts anti-/pro-apoptosis/pyroptosis/inflammation, chondrogenic differentiation and cell senescence effect in chondrocyte, synoviocyte and mesenchymal stem cell. retulator signature
IL6 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
IL6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL6 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature
IL6 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL6 autophagy 39893643 During the autophagic process mediated by CTSL, the IL6-JAK-STAT3 signalling pathway is activated, suggesting that CTSL promotes autophagy through the IL6-JAK-STAT3 pathway. retulator signature

Go Annotation:

GeneSymbol Go id
IL6 GO:0001781,GO:0002314,GO:0002384,GO:0002384,GO:0002446,GO:0002548,GO:0002639,GO:0002639,GO:0002675,GO:0002690,GO:0005125,GO:0005125,GO:0005125,GO:0005125,GO:0005125,GO:0005138,GO:0005138,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005896,GO:0005896,GO:0006953,GO:0006954,GO:0006954,GO:0006959,GO:0008083,GO:0008083,GO:0008284,GO:0008284,GO:0008284,GO:0008284,GO:0008285,GO:0010573,GO:0010574,GO:0010575,GO:0010628,GO:0010628,GO:0010628,GO:0010718,GO:0010888,GO:0014823,GO:0019221,GO:0030168,GO:0031018,GO:0031175,GO:0032494,GO:0032682,GO:0032722,GO:0032722,GO:0032731,GO:0032733,GO:0032740,GO:0032745,GO:0032755,GO:0032757,GO:0032760,GO:0032966,GO:0033138,GO:0035633,GO:0042102,GO:0042531,GO:0042531,GO:0042593,GO:0043065,GO:0043066,GO:0043410,GO:0045599,GO:0045669,GO:0045669,GO:0045727,GO:0045765,GO:0045779,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0046427,GO:0046427,GO:0046427,GO:0048661,GO:0050731,GO:0050768,GO:0050796,GO:0050829,GO:0050830,GO:0050871,GO:0051091,GO:0051384,GO:0051607,GO:0060252,GO:0061470,GO:0061888,GO:0070050,GO:0070091,GO:0070092,GO:0070102,GO:0070102,GO:0070301,GO:0071222,GO:0072540,GO:0072574,GO:0090091,GO:0090594,GO:0097421,GO:0098586,GO:0150077,GO:0150078,GO:1900017,GO:1901731,GO:1902512,GO:1903978,GO:1904894,GO:1904996,GO:2000553,GO:2000635,GO:2000660,GO:2000676

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL6 hsa:3569 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
IL6 hsa:3569 path:hsa01523 Antifolate resistance - Homo sapiens (human)
IL6 hsa:3569 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL6 hsa:3569 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
IL6 hsa:3569 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04218 Cellular senescence - Homo sapiens (human)
IL6 hsa:3569 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL6 hsa:3569 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL6 hsa:3569 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
IL6 hsa:3569 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
IL6 hsa:3569 path:hsa04931 Insulin resistance - Homo sapiens (human)
IL6 hsa:3569 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
IL6 hsa:3569 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05010 Alzheimer disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05020 Prion disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
IL6 hsa:3569 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05132 Salmonella infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05133 Pertussis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05134 Legionellosis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05135 Yersinia infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05142 Chagas disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05144 Malaria - Homo sapiens (human)
IL6 hsa:3569 path:hsa05146 Amoebiasis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05161 Hepatitis B - Homo sapiens (human)
IL6 hsa:3569 path:hsa05162 Measles - Homo sapiens (human)
IL6 hsa:3569 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05164 Influenza A - Homo sapiens (human)
IL6 hsa:3569 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IL6 hsa:3569 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL6 hsa:3569 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL6 hsa:3569 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
IL6 hsa:3569 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
IL6 hsa:3569 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
IL6 hsa:3569 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
IL6 hsa:3569 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL6 IL6R 11238858 11306493 11867689 12643274 12754507 1439146 14557255 14610620 15099563 15356132 15573129 15895091 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21071413 21115385 21840487 23034983 23180781 23331499 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 2788034 7512720 7521688 7543512 7590867 7744875 8706672 8837607 9694899 9845545 interaction type,stimulation,physical association anti tag coimmunoprecipitation,electron microscopy,nuclear magnetic resonance,chromatography technology,solid phase assay ACSN,InnateDB,SignaLink,SignaLink
JAK1 IL6 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK2 IL6 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TYK2 IL6 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
KLRG1 IL6 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 IL6 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTGER2 IL6 21209948 22025564 25916550 26192618 interaction type N/A ACSN
IL6 TGFBR1 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26192618 26201938 26268945 27557510 7590867 8837607 9845545 interaction type N/A ACSN
IL6 TGFBR2 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26192618 26201938 26268945 27557510 7590867 8837607 9845545 interaction type N/A ACSN
IL6 CEBPB 11306493 12706815 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23180781 23567181 24011634 24012417 24346288 25002027 25582338 26192618 26201938 26268945 27557510 7590867 8837607 9845545 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL6 STAT3 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
IKBKG IL6 10542212 10754326 10952726 11875494 12133805 12907458 14660645 15199157 15465827 15485931 15536066 15644117 15749903 16243976 16413922 16818229 16878026 16970925 17237376 17254973 17363905 17404308 17485448 17693255 18716620 20138012 20300203 21217011 21807870 22435554 23086447 23390297 23422957 23430059 26192618 2649237 28462531 7594497 9743347 interaction type N/A ACSN
TNIP3 IL6 10542212 10754326 10952726 11875494 12133805 12907458 14660645 15199157 15465827 15485931 15536066 15644117 15749903 16243976 16413922 16818229 16878026 16970925 17237376 17254973 17363905 17404308 17485448 17693255 18716620 20138012 20300203 21217011 21807870 22435554 23086447 23390297 23422957 23430059 26192618 2649237 28462531 7594497 9743347 interaction type N/A ACSN
IRF4 IL6 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
CD14 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
HIF1A IL6 10804084 15749903 16110315 16127144 16243976 16413922 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 26192618 9743347 interaction type N/A ACSN
IL6 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
FCAR IL6 12731048 15081523 15099567 20814939 23414611 2451784 26192618 7590867 9625766 9952373 interaction type N/A ACSN
FCER1G IL6 12731048 15081523 15099567 20814939 23414611 2451784 26192618 7590867 9625766 9952373 interaction type N/A ACSN
IL15 IL6 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL6 REL 1372388 19122653 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL6 NFKB1 1372388 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL6R IL6 14656210 23180781 physical association solid phase assay InnateDB
IL6 CRP 14656210 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL6 RBPJ 10373597 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL6 IL6ST 15895091 23180781 physical association electron microscopy,chromatography technology InnateDB
IL6 A2M 23180781 9780213 physical association comigration in non denaturing gel electrophoresis InnateDB
IL6 SH3GL2 16169070 23180781 physical association two hybrid InnateDB
IL6 RELA 19122653 20457835 21602809 22096605 23180781 24012417 24129565 physical association anti tag coimmunoprecipitation InnateDB
IL6 IRF1 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL6 STAT1 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL6 EP300 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL6 CREBBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL6 TBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL6 HNRNPA1 23180781 23985572 physical association anti tag coimmunoprecipitation InnateDB
RELA IL6 23180781 24761865 25888873 physical association anti tag coimmunoprecipitation InnateDB
BRD4 IL6 23180781 24761865 physical association anti tag coimmunoprecipitation InnateDB
TET2 IL6 23180781 26287468 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 IL6 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IL6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IL6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IL6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF IL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL6 15517885 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AHR IL6 18483242 20511231 23349129 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 IL6 16931790 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL6 11975924 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL6 10903137 11120852 8725624 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 IL6 8725624 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 IL6 12706815 trascriptional regulation,stimulation inferred by curator TFlink
EGR2 IL6 24007274 trascriptional regulation,stimulation inferred by curator TFlink
EP300 IL6 19966855 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 IL6 21185807 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL6 10542237 11120852 20225236 trascriptional regulation,stimulation inferred by curator TFlink
JUND IL6 11337499 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 IL6 23846700 trascriptional regulation,stimulation inferred by curator TFlink
MYC IL6 19259613 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL6 10329846 10823821 10903137 10963848 11120852 11327783 11504280 11975924 12058956 12887736 14532843 15158360 15517885 15756023 16112536 16984731 17040605 17196927 17490702 17532054 18057724 18061164 18243142 18942706 18996370 19124729 19164127 19469019 19707556 20066113 22547075 2405250 7876168 8679226 8725624 8752656 9516466 trascriptional regulation,stimulation inferred by curator TFlink
OTX2 IL6 21047732 trascriptional regulation,stimulation inferred by curator TFlink
PPARA IL6 15001458 trascriptional regulation,stimulation inferred by curator TFlink
RBPJ IL6 10329846 9516466 trascriptional regulation,stimulation inferred by curator TFlink
REL IL6 1372388 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL6 10329846 10542237 10823821 10903137 10963848 11120852 11327783 11504280 11975924 12058956 12887736 14532843 15158360 15517885 15756023 16112536 16984731 17040605 17196927 17490702 17532054 18057724 18061164 18243142 18942706 18996370 19124729 19164127 19469019 19707556 19966855 20066113 20457835 22547075 7499267 7876168 8679226 8752656 9516466 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IL6 18502099 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 IL6 18502099 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IL6 18616672 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL6 10391682 18616672 18765795 20930550 22105366 22363173 22547075 22927445 trascriptional regulation,stimulation inferred by curator TFlink
TBP IL6 9209275 trascriptional regulation,stimulation inferred by curator TFlink
VDR IL6 11050002 trascriptional regulation,stimulation inferred by curator TFlink
XBP1 IL6 16931790 trascriptional regulation,stimulation inferred by curator TFlink
ZFP36 IL6 21656745 trascriptional regulation,stimulation inferred by curator TFlink
ZNF823 IL6 21656745 trascriptional regulation,stimulation inferred by curator TFlink
ZMYND11 IL6 19379743 trascriptional regulation,stimulation inferred by curator TFlink
ZNF300 IL6 21777376 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPD IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 IL6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031B6ED IL6 21518763 rna interference,inhibition experimental interaction detection miRSponge
URS00004DA9DB IL6 21279994 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase
URS00001E0AEA IL6 21474672 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase
URS0000237AF9 IL6 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000031B6ED IL6 21518763 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000338542 IL6 18668040 20584899 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000122ED0 IL6 19088304 25416803 26367177 26587789 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008F0CF IL6 24429361 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000031E12 IL6 23977098 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000B7E30 IL6 24084739 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001C770D IL6 25416803 25916550 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000050CCE0 IL6 25416803 26338965 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 IL6 25265569 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 IL6 25416803 26563755 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 IL6 25416803 25950430 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000204177 IL6 25416803 26450567 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E857A IL6 25416803 27461244 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
IL6 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST IL6 25361965 interaction type N/A PTMCode2
IL6 IL6R 25361965 interaction type N/A PTMCode2
IL6R IL6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
IL6ST IL6 12829785 14525934 14557255 18775332 24234451 25348397 physical association biophysical,electron microscopy,experimental interaction detection,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
OSM IL6 25348397 N/A physical interaction,biochemical ComPPI
PTHLH IL6 12000745 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ZBTB16 IL6 14525934 16169070 24234451 25241761 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
SH3GL2 IL6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IL6R IL6 11238858 12829785 14525934 14557255 18775332 24234451 25348397 association,physical association affinity chromatography technology,coimmunoprecipitation,electron microscopy,experimental interaction detection,pull down,x-ray crystallography,physical interaction,biochemical,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
IL6 HRH1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
IL6 FAM20C 24234451 25348397 26091039 phosphorylation reaction protein kinase assay ComPPI,IntAct
IL6 NFKBIZ 24234451 26226212 association chromatin immunoprecipitation assay IntAct
SMARCA2 IL6 22334708 24234451 association chromatin immunoprecipitation assay IntAct
IL6 RELA 22334708 24234451 association chromatin immunoprecipitation assay IntAct
IL6 DPF3 22334708 24234451 association chromatin immunoprecipitation assay IntAct
IL6 IL6ST 11251120 14557255 15895091 19715447 27898060 3136546 7744001 9143707 stimulant N/A OmniPath
IL6 IL6R 11238858 12643274 12829785 14557255 14656210 15895091 23663276 2788034 27898060 3136546 7744001 7744875 8676083 8702737 8706672 9028955 9694899 stimulant N/A OmniPath
A2M IL6 27898060 9780213 N/A N/A OmniPath
CRP IL6 14656210 27898060 stimulant N/A OmniPath
IL6 SH3GL2 16169070 27898060 N/A N/A OmniPath

Visualization










  Return