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GENE：INS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol INS
FullNmae insulin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6081
EnsembleID ENSG00000254647
Uniprot P01308

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
INS mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
INS autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
INS apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
INS apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
INS GO:0000139,GO:0001819,GO:0002020,GO:0002674,GO:0005158,GO:0005158,GO:0005159,GO:0005179,GO:0005179,GO:0005179,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005796,GO:0006006,GO:0006355,GO:0006521,GO:0006953,GO:0007186,GO:0007267,GO:0008284,GO:0008286,GO:0010628,GO:0010629,GO:0010750,GO:0010750,GO:0022898,GO:0030133,GO:0030307,GO:0030335,GO:0031904,GO:0031954,GO:0032148,GO:0032880,GO:0033116,GO:0033861,GO:0034774,GO:0038060,GO:0042060,GO:0042177,GO:0042311,GO:0042311,GO:0042593,GO:0042593,GO:0042802,GO:0043410,GO:0045597,GO:0045721,GO:0045725,GO:0045818,GO:0045821,GO:0045821,GO:0045840,GO:0045861,GO:0045922,GO:0046326,GO:0046326,GO:0046628,GO:0046628,GO:0046631,GO:0046889,GO:0048167,GO:0050708,GO:0050709,GO:0050714,GO:0050890,GO:0050995,GO:0050995,GO:0051000,GO:0051092,GO:0051247,GO:0051897,GO:0055089,GO:0060266,GO:0060267,GO:0090277,GO:0090336,GO:1900182,GO:1900273,GO:1902176,GO:1902952,GO:1903076,GO:1903427,GO:1990535,GO:2000252

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
INS hsa:3630 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
INS hsa:3630 path:hsa04140 Autophagy - animal - Homo sapiens (human)
INS hsa:3630 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
INS hsa:3630 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
INS hsa:3630 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04911 Insulin secretion - Homo sapiens (human)
INS hsa:3630 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
INS hsa:3630 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
INS hsa:3630 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
INS hsa:3630 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
INS hsa:3630 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
INS hsa:3630 path:hsa04931 Insulin resistance - Homo sapiens (human)
INS hsa:3630 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
INS hsa:3630 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
INS hsa:3630 path:hsa04950 Maturity onset diabetes of the young - Homo sapiens (human)
INS hsa:3630 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
INS hsa:3630 path:hsa05010 Alzheimer disease - Homo sapiens (human)
INS hsa:3630 path:hsa05215 Prostate cancer - Homo sapiens (human)
INS hsa:3630 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
INS INS 10358076 17360977 2550426 26467481 8250835 9415393 interaction type,bind,up-regulates activity,down-regulates,down-regulates activity,down-regulates quantity by destabilization N/A Signor
INS IGF1R 1851182 18988627 23331499 stimulation N/A SignaLink,SignaLink
INS INSR 16956584 18988627 23331499 2550426 stimulation N/A SignaLink,SignaLink
INS F1QNX5 16956584 21559328 2550426 stimulation N/A SignaFish
INS Q1LWJ4 16849636 stimulation N/A SignaFish

Source Target Pmid Interactiontype Methods Database
KLF11 INS 15774581 18199129 18593768 21592955 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ATF2 INS 10909971 21278380 trascriptional regulation,stimulation inferred by curator TFlink
GLIS3 INS 23856252 trascriptional regulation,stimulation inferred by curator TFlink
MAFA INS 16461554 21830322 trascriptional regulation,stimulation inferred by curator TFlink
KLRG1 INS 16461554 21830322 trascriptional regulation,stimulation inferred by curator TFlink
NEUROD1 INS 10545951 16461554 trascriptional regulation,stimulation inferred by curator TFlink
NR1H4 INS 20060466 trascriptional regulation,stimulation inferred by curator TFlink
PAX4 INS 10601637 17426099 trascriptional regulation,stimulation inferred by curator TFlink
PDHX INS 10426567 10567373 10585868 20886630 7568086 trascriptional regulation,stimulation inferred by curator TFlink
PDX1 INS 10426567 10567373 10585868 20886630 7568086 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 INS 10567574 9665477 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 INS 10567574 9665477 trascriptional regulation,stimulation inferred by curator TFlink
AR INS N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 INS N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 INS N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA INS N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB INS N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG INS N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 INS N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 INS N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000321A1A INS 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000105D19 INS 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CRYAB INS 25348397 N/A physical interaction ComPPI
TXNDC17 INS 14525934 14607844 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
INS CCN3 10084601 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
INS IGFBP7 14525934 25348397 9388210 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
INS HLA-DQB1 11376336 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
INS SYTL4 10497219 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
INS HLA-DQA2 11376336 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
INS CPE 10966857 14525934 25348397 7477119 N/A experimental interaction detection,in vivo ComPPI,HPRD
INS CTSB 14525934 25348397 27898060 6351842 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
INS CTSD 11779865 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
INS CTSE 14525934 195962 1959628 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
INS GCK 12101177 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
INS RB1 10938588 14525934 25348397 27898060 7818556 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
INS IDE 11145591 14525934 17051221 25348397 27898060 N/A experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,protease assay,in vitro,protein cleavage ComPPI,HPRD,OmniPath
INS INSR 14525934 25348397 2550426 N/A experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vivo ComPPI,HPRD
INS DCN 24234451 24389353 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
INS KMT2A 25348397 N/A physical interaction ComPPI
INS APP 25348397 N/A physical interaction ComPPI
INS HSPB1 25348397 N/A physical interaction ComPPI
INS TCF4 25348397 N/A physical interaction ComPPI
INS RGS20 25348397 N/A physical interaction ComPPI
INS PTEN 25348397 N/A physical interaction ComPPI
INS GCG 24234451 24239544 25348397 colocalization fluorescence microscopy ComPPI,IntAct
INS CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INS NOTCH2NLA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INS KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INS HLA-DRB1 24234451 25348397 26437244 physical association x-ray crystallography ComPPI,IntAct
INS B2M 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
INS HLA-A 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
INS LILRB1 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
INS LILRB2 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
MAPK6 INS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IGF1R INS 14525934 1851182 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INS INS 10508408 12021212 14525934 17472440 20738396 23106816 23416304 23510797 24234451 8844841 N/A circular dichroism,dynamic light scattering,experimental interaction detection,fluorescence technology,molecular sieving,nuclear magnetic resonance,x-ray crystallography,blue native page,x-ray fiber diffraction,x ray scattering,atomic force microscopy HPRD,IntAct
LRP2 INS 14525934 27898060 9773776 N/A experimental interaction detection HPRD,OmniPath
INS SLC2A4 27898060 9415393 stimulant N/A OmniPath
INS IGF1R 1851182 27898060 stimulant N/A OmniPath
INS FOXO1 10358076 27898060 inhibition N/A OmniPath
CTSD INS 11779865 27898060 N/A N/A OmniPath
INS AKT1 12530968 27898060 stimulant N/A OmniPath
INS IRS1 12409308 27898060 inhibition,stimulant N/A OmniPath
INS PPARG 11279134 27898060 stimulant N/A OmniPath
INS INSR 11278498 15870194 23302862 2550426 27898060 stimulant N/A OmniPath
INS GSK3B 27898060 8250835 inhibition N/A OmniPath
CPE INS 10966857 27898060 7477119 N/A N/A OmniPath

Visualization










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