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GENE：EGF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EGF
FullNmae epidermal growth factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3229
EnsembleID ENSG00000138798
Uniprot P01133

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EGF necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EGF mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EGF GO:0001525,GO:0001938,GO:0002092,GO:0005085,GO:0005154,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005765,GO:0005886,GO:0007173,GO:0007173,GO:0008083,GO:0008284,GO:0010595,GO:0010628,GO:0010800,GO:0021930,GO:0021940,GO:0030297,GO:0030297,GO:0030335,GO:0030669,GO:0031093,GO:0038134,GO:0042327,GO:0043388,GO:0043406,GO:0043410,GO:0045740,GO:0045840,GO:0045893,GO:0046425,GO:0048018,GO:0048754,GO:0050673,GO:0050731,GO:0051048,GO:0051897,GO:0051897,GO:0060749,GO:0070062,GO:0070062,GO:0070371,GO:0090263,GO:0090279,GO:0090370,GO:1900127,GO:1902966,GO:1905278,GO:2000008,GO:2000060

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EGF hsa:1950 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
EGF hsa:1950 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04510 Focal adhesion - Homo sapiens (human)
EGF hsa:1950 path:hsa04540 Gap junction - Homo sapiens (human)
EGF hsa:1950 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
EGF hsa:1950 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
EGF hsa:1950 path:hsa05160 Hepatitis C - Homo sapiens (human)
EGF hsa:1950 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
EGF hsa:1950 path:hsa05200 Pathways in cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
EGF hsa:1950 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
EGF hsa:1950 path:hsa05210 Colorectal cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05213 Endometrial cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05214 Glioma - Homo sapiens (human)
EGF hsa:1950 path:hsa05215 Prostate cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05218 Melanoma - Homo sapiens (human)
EGF hsa:1950 path:hsa05219 Bladder cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05224 Breast cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05226 Gastric cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
EGF hsa:1950 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR EGF 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 EGF 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 EGF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EGF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 EGF 2833511 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 EGF 2833511 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 EGF N/A trascriptional regulation,stimulation inferred by curator TFlink
PGR EGF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000753AD EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000049704B EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 EGF 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C EGF 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 EGF 25416803 26876200 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
EGF ERBB2 25361965 interaction type N/A PTMCode2
ERBB2 EGF 25361965 interaction type N/A PTMCode2
EGF EGFR 25361965 interaction type N/A PTMCode2
EGFR EGF 25361965 interaction type N/A PTMCode2
EGF GRB2 25361965 interaction type N/A PTMCode2
GRB2 EGF 25361965 interaction type N/A PTMCode2
EGF ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 EGF 25361965 interaction type N/A PTMCode2
EGF LMNA 25361965 interaction type N/A PTMCode2
LMNA EGF 25361965 interaction type N/A PTMCode2
PIK3R2 EGF 25361965 interaction type N/A PTMCode2
EGF PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 EGF 1334406 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBE2I EGF 25348397 N/A physical interaction ComPPI
S100A4 EGF 19740107 24234451 25348397 N/A far western blotting ComPPI,IntAct
EMD EGF 25348397 N/A physical interaction ComPPI
LMNA EGF 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PCGF2 EGF 25348397 N/A physical interaction ComPPI
ERBB2 EGF 12093292 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ADAM12 EGF 11786904 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRB2 EGF 10973965 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FGF5 EGF 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PCOLCE EGF 25348397 N/A surface plasmon resonance array ComPPI
VTN EGF 11796824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DUSP3 EGF 1281549 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SREBF1 EGF 25348397 N/A physical interaction ComPPI
GRK2 EGF 14525934 15620700 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGF CPM 14525934 25348397 7615511 8796265 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGF EGFR 10788520 12093292 12297050 12620237 14525934 15620700 16274239 17697999 21439278 21822280 23597562 24234451 25241761 25348397 26280537 2790960 physical association affinity chromatography technology,anti bait coimmunoprecipitation,transmission electron microscopy,experimental interaction detection,fluorescence-activated cell sorting,molecular sieving,scintillation proximity assay,surface plasmon resonance,x-ray crystallography,physical interaction,biochemical,electron tomography,saturation binding,in vitro,in vivo,proximity ligation assay,x ray scattering,surface plasmon resonance array ComPPI,HPRD,IntAct
EGF FNBP1 25348397 N/A physical interaction ComPPI
EGF ERBB3 12093292 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EGF ZFYVE28 25348397 N/A physical interaction ComPPI
EGF LMNB1 25348397 N/A physical interaction ComPPI
EGF RPS6KA5 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
EGF HDAC6 20029029 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
EGF MGST1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EGF EGF 11438527 14525934 9188692 N/A experimental interaction detection,two hybrid HPRD
NRG1 EGF 14525934 7730382 N/A experimental interaction detection HPRD
EGF EGFR 10085134 10788520 10970856 11684674 12093292 12297050 12620237 12648462 15620700 16274239 17697999 18271526 18427122 19531499 20458382 21439278 21822280 2186024 25241761 27898060 2790960 3494473 6289330 8663535 stimulant N/A OmniPath
EGF ERBB2 11279155 12093292 27898060 stimulant N/A OmniPath
EGF ERBB4 27898060 9305636 N/A N/A OmniPath
CPM EGF 27898060 7615511 8796265 N/A N/A OmniPath

Visualization










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