GENE：KAT8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KAT8 |
| FullNmae | lysine acetyltransferase 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17933 |
| EnsembleID | ENSG00000103510 |
| Uniprot | Q9H7Z6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KAT8 | autophagy | 38777823 | Altogether, our study provides additional support for KAT8 as a regulator of mitophagy and autophagy processes. | retulator signature |
| KAT8 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| KAT8 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KAT8 | GO:0000123,GO:0000776,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006338,GO:0010506,GO:0016363,GO:0019899,GO:0022008,GO:0030099,GO:0043995,GO:0043996,GO:0044545,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045893,GO:0045944,GO:0046872,GO:0046972,GO:0046972,GO:0051571,GO:0061629,GO:0071339,GO:0072487,GO:0072487,GO:1900095 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KAT8 | CREB1 | 18160048 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| KAT8 | LYL1 | 18160048 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| KAT8 | KAT8 | 21502975 23180781 | acetylation reaction,physical association | pull down,enzymatic study | InnateDB |
| KAT8 | SIRT1 | 21502975 23180781 | physical association | pull down | InnateDB |
| HOXA9 | KAT8 | 21502975 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KAT8 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | KAT8 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | KAT8 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | KAT8 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KAT8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | KAT8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KAT8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | KAT8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | KAT8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HCFC1 | KAT8 | 25361965 | interaction type | N/A | PTMCode2 |
| KAT8 | HCFC1 | 25361965 | interaction type | N/A | PTMCode2 |
| RBBP5 | KAT8 | 25361965 | interaction type | N/A | PTMCode2 |
| KAT8 | RBBP5 | 25361965 | interaction type | N/A | PTMCode2 |
| RNF2 | KAT8 | 25361965 | interaction type | N/A | PTMCode2 |
| KAT8 | RNF2 | 25361965 | interaction type | N/A | PTMCode2 |
| TP53 | KAT8 | 25361965 | interaction type | N/A | PTMCode2 |
| KAT8 | TP53 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KANSL1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CB | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| H2BC4 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| PRKDC | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| HCFC1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| PLK1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| ASH2L | KAT8 | 15960975 24234451 25348397 | colocalization | cosedimentation in solution | ComPPI,IntAct |
| DYRK1B | KAT8 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| TPR | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| ATM | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP5 | KAT8 | 15960975 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MORF4L1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAE | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| MCRS1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | KAT8 | 15960975 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,physical interaction,in vivo | ComPPI,IntAct |
| OGT | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | KAT8 | 21502975 22586264 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TNK2 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| BAZ2A | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| ELOA | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| H2AX | KAT8 | 20224553 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD4 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| HECW2 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| FOXP3 | KAT8 | 25348397 | N/A | physical interaction | ComPPI |
| KMT2A | KAT8 | 15960975 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| KAT8 | TP53 | 15960975 16601686 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| KAT8 | MSL1 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | MSL2 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | MSL3 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | CCAR2 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | PHF20 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | PHF20L1 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | PAF1 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | H2BC11 | 25348397 | N/A | physical interaction | ComPPI |
| KAT8 | PLAU | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | KAT8 | 15960975 24234451 25348397 27705803 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| KAT8 | H4C1 | 15923642 16024812 16227571 19056256 19766566 20479123 23415232 27898060 | stimulant | N/A | OmniPath |
| KMT2A | KAT8 | 15960975 27898060 | stimulant | N/A | OmniPath |
| KAT8 | BAZ2A | 19578370 27898060 | N/A | N/A | OmniPath |