GENE：LEP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LEP |
| FullNmae | leptin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6553 |
| EnsembleID | ENSG00000174697 |
| Uniprot | P41159 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LEP | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LEP | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LEP | GO:0000122,GO:0001525,GO:0001542,GO:0001666,GO:0001890,GO:0001934,GO:0001936,GO:0002021,GO:0003300,GO:0003677,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005829,GO:0006006,GO:0006111,GO:0006112,GO:0006114,GO:0006629,GO:0006635,GO:0006909,GO:0007260,GO:0007565,GO:0007623,GO:0008203,GO:0008206,GO:0008217,GO:0008340,GO:0008343,GO:0010507,GO:0010888,GO:0014823,GO:0019953,GO:0021954,GO:0030073,GO:0030217,GO:0030300,GO:0032008,GO:0032008,GO:0032099,GO:0032310,GO:0032355,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0032814,GO:0032817,GO:0032868,GO:0032869,GO:0033197,GO:0033210,GO:0033686,GO:0035360,GO:0035556,GO:0035630,GO:0035904,GO:0038108,GO:0038108,GO:0042102,GO:0042269,GO:0042307,GO:0042445,GO:0042531,GO:0042593,GO:0042755,GO:0043066,GO:0043270,GO:0043410,GO:0043410,GO:0044320,GO:0045471,GO:0045765,GO:0045906,GO:0046325,GO:0046427,GO:0046427,GO:0046628,GO:0046850,GO:0046881,GO:0048639,GO:0050796,GO:0050810,GO:0050892,GO:0050901,GO:0050999,GO:0051428,GO:0051541,GO:0051726,GO:0051897,GO:0051897,GO:0060587,GO:0060612,GO:0061037,GO:0070093,GO:0071298,GO:0071300,GO:0090335,GO:0098868,GO:0120162,GO:1900015,GO:1900745,GO:1900745,GO:1904651,GO:1990051,GO:1990051,GO:1990460,GO:2000379,GO:2000486,GO:2000491 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LEP | hsa:3952 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| LEP | hsa:3952 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| LEP | hsa:3952 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| LEP | hsa:3952 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| LEP | hsa:3952 | path:hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| LEP | hsa:3952 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LEP | SIGLEC6 | 10428856 23180781 | physical association | surface plasmon resonance | InnateDB |
| LEP | SIGLEC5 | 10428856 23180781 | physical association | surface plasmon resonance | InnateDB |
| LEP | CD33 | 10428856 23180781 | physical association | surface plasmon resonance | InnateDB |
| CEBPD | LEP | 23180781 25889814 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HIF1A | LEP | 23180781 25889814 | physical association | anti tag coimmunoprecipitation | InnateDB |
| LEP | LEPR | 23331499 9207021 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | LEP | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | LEP | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | LEP | 18559540 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TBP | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LEP | 18971253 21983012 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | LEP | 18559540 18971253 19080496 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | LEP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KHDRBS1 | LEP | 21672929 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | LEP | 18559540 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | LEP | 18242580 19492417 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNT | LEP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPB | LEP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPD | LEP | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| STAT3 | LEP | 25361965 | interaction type | N/A | PTMCode2 |
| LEP | STAT3 | 25361965 | interaction type | N/A | PTMCode2 |
| LEP | LEPR | 25361965 | interaction type | N/A | PTMCode2 |
| LEPR | LEP | 25361965 | interaction type | N/A | PTMCode2 |
| LEP | GHRL | 25361965 | interaction type | N/A | PTMCode2 |
| GHRL | LEP | 25361965 | interaction type | N/A | PTMCode2 |
| LEP | PRKAA2 | 25361965 | interaction type | N/A | PTMCode2 |
| PRKAA2 | LEP | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAA2 | LEP | 11797013 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CLU | LEP | 25348397 | N/A | in vitro,in vivo | ComPPI |
| LEPR | LEP | 14525934 22405007 24234451 25348397 8608603 | N/A | cross-linking study,experimental interaction detection,molecular sieving,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| GHRL | LEP | 11196643 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| UCN | LEP | 12535698 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| A2M | LEP | 14525934 25348397 27898060 9724081 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| LEP | CRP | 14525934 16582918 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| LEP | HK3 | 11068878 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| LEP | SIGLEC6 | 10428856 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LEP | HSF2BP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SIGLEC5 | LEP | 10428856 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| LEP | LEPR | 22405007 27898060 8608603 9207021 9463481 9786864 | stimulant | N/A | OmniPath |
| SIGLEC6 | LEP | 10428856 27898060 | N/A | N/A | OmniPath |
| SIGLEC5 | LEP | 10428856 27898060 | N/A | N/A | OmniPath |
| CD33 | LEP | 10428856 27898060 | N/A | N/A | OmniPath |