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GENE：MEFV

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MEFV
FullNmae MEFV innate immunity regulator, pyrin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6998
EnsembleID ENSG00000103313
Uniprot O15553

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MEFV autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MEFV autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MEFV GO:0001726,GO:0002221,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005776,GO:0005829,GO:0005829,GO:0005829,GO:0005874,GO:0005875,GO:0006954,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0030027,GO:0031410,GO:0032651,GO:0032691,GO:0032695,GO:0032731,GO:0034341,GO:0042802,GO:0045087,GO:0050728,GO:0050729,GO:0061630,GO:0061702,GO:0070269,GO:0071641,GO:1900016,GO:1900226,GO:1904270,GO:2001056

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MEFV hsa:4210 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
MEFV hsa:4210 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
MEFV hsa:4210 path:hsa05135 Yersinia infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MEFV NLRP3 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
MEFV PYCARD 14595024 16037825 17431422 17964261 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid InnateDB
MEFV CASP1 16037825 16785446 17431422 18577712 23180781 cleavage reaction,physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down,protease assay InnateDB
MEFV CASP5 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
MEFV NLRP1 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
MEFV NLRP2 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
MEFV RELA 14514692 18577712 23180781 physical association anti tag coimmunoprecipitation,pull down,electrophoretic mobility supershift assay InnateDB
NFKBIA MEFV 18577712 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MEFV PSTPIP1 14595024 17964261 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
MEFV MEFV 17964261 23180781 physical association cross-linking study InnateDB
MEFV SIVA1 18330885 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
MEFV CEBPB 14514692 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 MEFV 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MEFV 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA MEFV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MEFV 18971253 20805247 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB MEFV N/A trascriptional regulation,stimulation inferred by curator TFlink
RELA MEFV N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PKN1 MEFV 22135298 phosphorylation N/A PhosphoSite
PKN2 MEFV 22135298 phosphorylation N/A PhosphoSite
MEFV PYCARD 25361965 interaction type N/A PTMCode2
PYCARD MEFV 25361965 interaction type N/A PTMCode2
MEFV COG5 25361965 interaction type N/A PTMCode2
COG5 MEFV 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 MEFV 25348397 N/A physical interaction ComPPI
GABARAPL2 MEFV 25348397 N/A physical interaction ComPPI
CASP1 MEFV 16785446 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
YWHAQ MEFV 15934090 24234451 25348397 27898060 association coimmunoprecipitation ComPPI,IntAct,OmniPath
SIVA1 MEFV 25348397 N/A physical interaction ComPPI
PSTPIP1 MEFV 14525934 14595024 17964261 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
GABARAP MEFV 25348397 N/A physical interaction ComPPI
MAP1LC3A MEFV 25348397 N/A physical interaction ComPPI
LGALS8 MEFV 25348397 N/A physical interaction ComPPI
PYCARD MEFV 11498534 12054656 12646168 14525934 17964261 24234451 25006247 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vivo,two hybrid ComPPI,HPRD,IntAct
MEFV COG5 10782044 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
MEFV ULK1 25348397 N/A physical interaction ComPPI
MEFV BECN1 25348397 N/A physical interaction ComPPI
MEFV ATG16L1 25348397 N/A physical interaction ComPPI
MEFV GABARAPL1 25348397 N/A physical interaction ComPPI
MEFV MAP1LC3C 25348397 N/A physical interaction ComPPI
MEFV NLRP3 25348397 N/A physical interaction ComPPI
MEFV MEFV 17964261 22829933 24234451 25006247 physical association two hybrid,cross-linking study,molecular sieving,pull down IntAct
MEFV H1-2 24234451 30021884 physical association cross-linking study IntAct
MEFV CASP1 16037825 16785446 17431422 18577712 27898060 N/A N/A OmniPath
CASP1 MEFV 16037825 16785446 17431422 18577712 27898060 stimulant N/A OmniPath
MEFV NLRP1 17431422 27898060 N/A N/A OmniPath
MEFV PYCARD 11498534 12054656 12646168 14595024 16037825 17431422 17964261 27898060 inhibition N/A OmniPath
PYCARD MEFV 11498534 12054656 12646168 14595024 16037825 17431422 17964261 27898060 N/A N/A OmniPath
MEFV NLRP3 17431422 27898060 N/A N/A OmniPath
MEFV SIVA1 18330885 27898060 N/A N/A OmniPath
NFKBIA MEFV 18577712 27898060 N/A N/A OmniPath
MEFV CASP5 17431422 27898060 N/A N/A OmniPath
RELA MEFV 14514692 18577712 27898060 N/A N/A OmniPath
MEFV PSTPIP1 14595024 17964261 27898060 N/A N/A OmniPath
MEFV NLRP2 17431422 27898060 N/A N/A OmniPath

Visualization










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