GENE:MET
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | MET |
FullNmae | MET proto-oncogene, receptor tyrosine kinase |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:7029 |
EnsembleID | ENSG00000105976 |
Uniprot | P08581 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
MET | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MET | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MET | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MET | autophagy | 35061934 | We further found that FOXP2 inhibited MET Proto-Oncogene (MET), which was the initiating factor that regulated the classic AKT/mTOR pathway of autophagy. | retulator signature |
MET | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
MET | GO:0001886,GO:0001889,GO:0004713,GO:0004713,GO:0005008,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0006909,GO:0007165,GO:0007166,GO:0007169,GO:0007275,GO:0007399,GO:0009925,GO:0009925,GO:0009986,GO:0010507,GO:0016020,GO:0016310,GO:0016477,GO:0017154,GO:0019903,GO:0030182,GO:0031016,GO:0031116,GO:0033674,GO:0035024,GO:0042802,GO:0043235,GO:0045944,GO:0048012,GO:0048754,GO:0050918,GO:0051497,GO:0061436,GO:0070495,GO:0071526,GO:0140677,GO:1901299,GO:1905098,GO:2001028 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
MET | hsa:4233 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
MET | hsa:4233 | path:hsa04520 | Adherens junction - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05144 | Malaria - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05218 | Melanoma - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
MET | hsa:4233 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MET | CDH1 | 16909210 23180781 | phosphorylation reaction,physical association | anti tag coimmunoprecipitation | InnateDB |
CTNNB1 | MET | 16909210 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
MET | FOXC2 | 23180781 25381815 | physical association | anti tag coimmunoprecipitation | InnateDB |
HGF | MET | 23331499 8380735 | stimulation | N/A | SignaLink |
CBL | MET | 11894096 15123609 16397241 18273061 19450681 23331499 | stimulation | N/A | SignaLink |
MET | GLMN | 11571281 23331499 | stimulation | N/A | SignaLink |
MET | GRAP | 23331499 8662889 | stimulation | N/A | SignaLink |
MET | RANBP9 | 12147692 23331499 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GAB1 | MET | 20005715 | interaction type | N/A | PSP |
GRB2 | MET | 20005715 | interaction type | N/A | PSP |
HGS | MET | 20005715 | interaction type | N/A | PSP |
PIK3R1 | MET | 20005715 | interaction type | N/A | PSP |
SHC1 | MET | 20005715 | interaction type | N/A | PSP |
YWHAZ | MET | 20005715 | interaction type | N/A | PSP,SignaLink |
HGS | MET | 18988627 20005715 8380735 | N/A | N/A | SignaLink |
GRB2 | MET | 20005715 21071413 8662889 9660480 | N/A | N/A | SignaLink |
GAB1 | MET | 20005715 20005715 | N/A | N/A | SignaLink |
PIK3R1 | MET | 20005715 20005715 | N/A | N/A | SignaLink |
SHC1 | MET | 18988627 20005715 20005715 21071413 7731718 9660480 | N/A | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | MET | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
GATA2 | MET | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
HIF1A | MET | 16099863 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
MYC | MET | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
YBX1 | MET | 19151767 19648825 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
PRDM14 | MET | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | MET | 17371876 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | MET | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP2 | MET | 21832174 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PAX3 | MET | 8633043 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PAX5 | MET | 19139719 24628993 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PAX6 | MET | 19651775 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SMAD7 | MET | 15339794 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP1 | MET | 11910354 21831840 | trascriptional regulation,stimulation | inferred by curator | TFlink |
DAND5 | MET | 11910354 21831840 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | MET | 21831840 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ETS1 | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
JUN | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
NFKB1 | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP3 | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT1 | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT5A | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT5B | MET | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000032BD73 | MET | 20505319 | rna interference,inhibition | experimental interaction detection | miRSponge |
URS0000338542 | MET | N/A | rna interference,inhibition | experimental interaction detection | miRSponge |
URS000034B6F5 | MET | 19620785 19710019 20388878 \N | rna interference,inhibition | western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS0000183BED | MET | 19490101 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS0000001EB3 | MET | 23552883 23553486 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
URS0000007FBA | MET | 21225860 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miRSponge |
URS00000EED18 | MET | 18834857 19006648 19029026 19461653 19773441 20309880 22159222 22457788 \N | rna interference,inhibition | western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS000027352D | MET | 19461653 20924086 22419847 | rna interference,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS00002C7B2B | MET | 19461653 20198305 20924086 22419847 \N | rna interference,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS00001F5B39 | MET | 21418558 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
URS00003758F0 | MET | 21418558 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
URS0000315338 | MET | 21706050 22743998 23418453 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr | miRDeathDB,TarBase |
URS000000C73C | MET | 21868754 22743998 | mrna cleavage,inhibition | N/A | miRDeathDB |
URS000034B6F5 | MET | 18927107 19620785 19710019 20388878 25416803 26186594 | mrna cleavage,inhibition | experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
URS00002C7B2B | MET | 19461653 20198305 20924086 22419847 23922103 25416803 26795575 | mrna cleavage,inhibition | array technology,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS000027352D | MET | 19461653 20924086 22419847 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00000EED18 | MET | 18834857 19006648 19029026 19461653 19773441 20309880 21240262 22159222 22457788 23970470 24983493 25416803 26238271 26313360 27364974 27513895 28250026 | mrna cleavage,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
URS0000183BED | MET | 19490101 25405368 25416803 28077801 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000065D58 | MET | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
URS0000007FBA | MET | 21692045 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
URS00001F5B39 | MET | 21418558 23734217 25416803 26471185 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00003758F0 | MET | 21418558 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
URS000032BD73 | MET | 20505319 24391788 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot | TarBase |
URS0000001EB3 | MET | 22948084 23552883 23553486 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
URS000032FC1A | MET | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00003CF1AD | MET | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00001B341F | MET | 23650389 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00001E3523 | MET | 23151846 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00002233F4 | MET | 22750473 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00003BBF48 | MET | 24013226 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
URS00002198F3 | MET | 25416803 26141986 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000081E1F | MET | 23820886 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00002E92A8 | MET | 25416803 25927670 25961751 26250785 | mrna cleavage,inhibition | array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS000024DFCE | MET | 25416803 26844702 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
URS000023BE29 | MET | 25416803 26497851 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000330617 | MET | 25405368 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000568FF8 | MET | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
URS000048BA36 | MET | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
URS000075A611 | MET | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
URS00002E1509 | MET | 25416803 28735896 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PRKCD | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
ABL1 | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
BMX | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
MST1R | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
MET | PARP1 | 22135298 | phosphorylation | N/A | PhosphoSite |
MET | SHC1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
MET | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
MET | MST1R | 22135298 | phosphorylation | N/A | PhosphoSite |
MET | PTK2 | 22135298 | phosphorylation | N/A | PhosphoSite |
PRKG2 | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
FER | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
PRKCE | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
PRKCA | MET | 22135298 | phosphorylation | N/A | PhosphoSite |
STAT3 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | STAT3 | 25361965 | interaction type | N/A | PTMCode2 |
CBL | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | CBL | 25361965 | interaction type | N/A | PTMCode2 |
MET | SPSB1 | 25361965 | interaction type | N/A | PTMCode2 |
SPSB1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | HGS | 25361965 | interaction type | N/A | PTMCode2 |
HGS | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
GRB2 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
CTNNB1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | SRC | 25361965 | interaction type | N/A | PTMCode2 |
SRC | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | GLMN | 25361965 | interaction type | N/A | PTMCode2 |
GLMN | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | PTPN1 | 25361965 | interaction type | N/A | PTMCode2 |
PTPN1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | SH3KBP1 | 25361965 | interaction type | N/A | PTMCode2 |
SH3KBP1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | SOS1 | 25361965 | interaction type | N/A | PTMCode2 |
SOS1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | MUC20 | 25361965 | interaction type | N/A | PTMCode2 |
MUC20 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | PTPRJ | 25361965 | interaction type | N/A | PTMCode2 |
PTPRJ | MET | 25361965 | interaction type | N/A | PTMCode2 |
SHC1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
RANBP10 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | RANBP10 | 25361965 | interaction type | N/A | PTMCode2 |
CASP3 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | CASP3 | 25361965 | interaction type | N/A | PTMCode2 |
GAB1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | GAB1 | 25361965 | interaction type | N/A | PTMCode2 |
ITGB4 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | ITGB4 | 25361965 | interaction type | N/A | PTMCode2 |
INPPL1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | INPPL1 | 25361965 | interaction type | N/A | PTMCode2 |
EGFR | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
CDH1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | CDH1 | 25361965 | interaction type | N/A | PTMCode2 |
RANBP9 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | RANBP9 | 25361965 | interaction type | N/A | PTMCode2 |
BAG1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | BAG1 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R1 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | PIK3R1 | 25361965 | interaction type | N/A | PTMCode2 |
HGF | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | HGF | 25361965 | interaction type | N/A | PTMCode2 |
GAB2 | MET | 25361965 | interaction type | N/A | PTMCode2 |
MET | GAB2 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
NCK2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SPSB3 | MET | 25348397 | N/A | physical interaction | ComPPI |
PIK3R2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SOCS3 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
YES1 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PCBD2 | MET | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
SH3KBP1 | MET | 25348397 | N/A | physical interaction | ComPPI |
PCBP1 | MET | 25348397 | N/A | physical interaction | ComPPI |
HSP90AB1 | MET | 25348397 | N/A | physical interaction | ComPPI |
CRK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy,physical interaction | ComPPI,IntAct |
STAP1 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
CD44 | MET | 22897854 24234451 25348397 | physical association | cross-linking study | ComPPI,IntAct |
GRB7 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
CBL | MET | 11894096 14525934 18273061 21163258 24234451 25241761 25348397 | ubiquitination reaction,physical association | anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,mass spectrometry studies of complexes,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid | ComPPI,HPRD,IntAct |
VAV1 | MET | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
BTK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SYK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SHB | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
TEC | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SH3BP2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SOCS1 | MET | 24234451 24728074 25348397 25728680 27898060 | N/A | fluorescence polarization spectroscopy,physical interaction | ComPPI,IntAct,OmniPath |
VAV2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
LYN | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PIK3R1 | MET | 14525934 24234451 24728074 25348397 7513258 | N/A | experimental interaction detection,fluorescence polarization spectroscopy,in vitro | ComPPI,HPRD,IntAct |
PTPN11 | MET | 14525934 18579758 24234451 24728074 25348397 8662733 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,in vivo | ComPPI,HPRD,IntAct |
SRC | MET | 14525934 20624308 24034250 24234451 24728074 25348397 9837958 | association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vivo | ComPPI,HPRD,IntAct |
MATK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PTPRO | MET | 19167335 24234451 25348397 28330616 | dephosphorylation reaction,association | pull down,phosphatase assay | ComPPI,IntAct |
SH2B3 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
LCK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SH2B2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
INPP5D | MET | 14525934 15735664 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
VAV3 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
KDR | MET | 22789536 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
PLCG2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SHC1 | MET | 14525934 24234451 24728074 25348397 7731718 | N/A | experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vivo | ComPPI,HPRD,IntAct |
SOS1 | MET | 25348397 | N/A | physical interaction | ComPPI |
NCK1 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
CASP3 | MET | 14525934 15542841 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
GAB2 | MET | 25348397 | N/A | physical interaction | ComPPI |
CBLC | MET | 25348397 | N/A | physical interaction | ComPPI |
GRB2 | MET | 11439336 14525934 15546961 25348397 7511210 8662889 9660480 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
ZAP70 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
ITK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
BLK | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
INPPL1 | MET | 14525934 15735664 24234451 24728074 25348397 | N/A | two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
SLA2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
YWHAZ | MET | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
FES | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
HGS | MET | 14525934 25348397 8380735 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
GAB1 | MET | 10734310 10913131 10995442 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
PIK3R3 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
HSP90AA1 | MET | 25348397 | N/A | physical interaction | ComPPI |
CDH1 | MET | 25348397 | N/A | physical interaction | ComPPI |
PTPN1 | MET | 16537444 18579758 22789536 24234451 25348397 | dephosphorylation reaction,physical association | anti bait coimmunoprecipitation,cross-linking study,phosphatase assay | ComPPI,IntAct |
BAG1 | MET | 25348397 | N/A | in vivo | ComPPI |
GRB14 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SNX2 | MET | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
TNS2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
SOCS2 | MET | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
PTPRB | MET | 14525934 16101282 24234451 25348397 | dephosphorylation reaction | experimental interaction detection,phosphatase assay,in vitro | ComPPI,HPRD,IntAct |
DNAJA3 | MET | 14525934 15546961 21242965 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,two hybrid,pull down,confocal microscopy,two hybrid | ComPPI,HPRD,IntAct |
PTPRG | MET | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
HGFAC | MET | 25348397 27898060 9537587 | N/A | experimental interaction detection,physical interaction | ComPPI,OmniPath |
PTPN12 | MET | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
DAPK3 | MET | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
PKM | MET | 25348397 | N/A | protein kinase assay | ComPPI |
RANBP9 | MET | 12147692 14525934 24234451 25348397 | physical association | two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
MET | SNAPIN | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
MET | SMC1A | 14525934 15546961 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
MET | STAT3 | 14525934 25348397 9440692 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
MET | CNR1 | 11894096 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
MET | EGFR | 10722725 14525934 20624308 23866081 24189400 24234451 25348397 26551075 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,experimental interaction detection,phosphorylation reaction,physical interaction,protein kinase assay,in vitro,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
MET | CTNNB1 | 11929826 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
MET | FAS | 14525934 15911745 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
MET | ITGB4 | 11733063 14525934 14602071 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
MET | SPSB1 | 14525934 15713673 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
MET | CTTN | 11439336 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
MET | HGF | 14525934 15167892 16537482 1655405 17804794 17981115 1846706 18495663 24234451 25348397 | physical association | cross-linking study,experimental interaction detection,fluorescent resonance energy transfer,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,x ray scattering,amplified luminescent proximity homogeneous assay | ComPPI,HPRD,IntAct |
MET | PLXNB1 | 12198496 14525934 15184888 22404908 24234451 25348397 | phosphorylation reaction,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,IntAct |
MET | GLMN | 11571281 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
MET | RANBP10 | 14525934 14684163 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
MET | MUC20 | 25348397 | N/A | two hybrid,in vitro,in vivo | ComPPI |
MET | LRIG1 | 17178829 24828152 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
MET | DCN | 25348397 | N/A | physical interaction | ComPPI |
MET | SPSB2 | 25348397 | N/A | physical interaction | ComPPI |
MET | SPSB4 | 25348397 | N/A | physical interaction | ComPPI |
MET | STUB1 | 25348397 | N/A | physical interaction | ComPPI |
MET | HSPA4 | 25348397 | N/A | physical interaction | ComPPI |
MET | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
MET | GGA3 | 21664574 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
MET | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
MET | CEACAM21 | 25348397 | N/A | physical interaction | ComPPI |
MET | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
MET | ERBB3 | 24234451 25326665 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MET | SCGB1D1 | 25348397 | N/A | physical interaction | ComPPI |
MET | PTPRC | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
MET | PTPRK | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
MET | PTPRJ | 12370829 12475979 14525934 19167335 24234451 25348397 | dephosphorylation reaction,physical association | affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,pull down,biochemical,phosphatase assay | ComPPI,HPRD,IntAct |
MET | PTPN3 | 19167335 24234451 25348397 | dephosphorylation reaction | phosphatase assay | ComPPI,IntAct |
MET | PLXNB2 | 15184888 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation | ComPPI,IntAct |
MET | PLXNB3 | 15184888 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation | ComPPI,IntAct |
MET | PASK | 21418524 24234451 25348397 | phosphorylation reaction | peptide array | ComPPI,IntAct |
MET | MUC1 | 22962849 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
MET | RASA1 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SOCS6 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SHC4 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SH2D1B | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SHD | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SHC2 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SH2D3C | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | TNS3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SH2D2A | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SH2D1A | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | PLCG1 | 14525934 24234451 24728074 25348397 7513258 8662733 | N/A | experimental interaction detection,fluorescence polarization spectroscopy | ComPPI,HPRD,IntAct |
MET | SOCS5 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | TNS1 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | FGR | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SHC3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | HCK | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | PTK6 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | TXK | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | ABL2 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | HSH2D | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | SH2B1 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | TNS4 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | BCAR3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
MET | LAPTM4B | 24234451 25348397 25594178 | colocalization,physical association | anti tag coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct |
MET | SCRIB | 24234451 24550280 25348397 | physical association | phage display | ComPPI,IntAct |
MET | LAMP1 | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
GNG12 | MET | 25348397 | N/A | physical interaction | ComPPI |
MET | MET | 14525934 16537482 1655405 1655790 17192257 20624990 24234451 | physical association | cross-linking study,experimental interaction detection,amplified luminescent proximity homogeneous assay | HPRD,IntAct |
PRKCA | MET | 15075332 27898060 8294430 | inhibition | N/A | OmniPath |
PTPN1 | MET | 16537444 18579758 18819921 22789536 27898060 | inhibition | N/A | OmniPath |
PRKCE | MET | 15075332 27898060 | inhibition | N/A | OmniPath |
PRKCD | MET | 15075332 27898060 | N/A | N/A | OmniPath |
MET | ITGB4 | 11733063 14602071 27898060 | N/A | N/A | OmniPath |
PTPRF | MET | 16415345 27898060 | N/A | N/A | OmniPath |
PTPN2 | MET | 18819921 27898060 | inhibition | N/A | OmniPath |
MET | PTK2 | 11909938 14739293 15026417 15561106 15707572 16782899 17317726 19815712 20658524 20802513 20802517 27898060 | stimulant | N/A | OmniPath |
MET | GAB1 | 10734310 10753869 10871282 10913131 10978177 10995442 14685170 16497976 17016520 17389395 18669648 19901323 20068231 27898060 9242692 | stimulant | N/A | OmniPath |
TP53 | MET | 18431400 27898060 | stimulant | N/A | OmniPath |
MET | SHC1 | 11687594 11884620 14685170 14990987 15688026 15708852 18687633 19690143 24728074 27898060 7731718 8084588 8939605 8947042 9083103 | stimulant | N/A | OmniPath |
CBL | MET | 11894096 15123609 16397241 18273061 19433454 19450681 21163258 21222362 25241761 27898060 | inhibition,stimulant | N/A | OmniPath |
HGF | MET | 14685170 15167892 16537482 1655405 17145710 17804794 17981115 1846706 18495663 19433454 20624990 27898060 8380735 | stimulant | N/A | OmniPath |
MET | RANBP9 | 12147692 27898060 | stimulant | N/A | OmniPath |
DCN | MET | 10942781 19433454 27898060 | N/A | N/A | OmniPath |
MET | MST1R | 10490849 10506185 10871856 11064459 11741535 12475979 12766170 16782899 18836480 20016000 20726546 21777671 27898060 7513258 7687741 7731718 7838524 7961992 8547236 8906793 9242692 9391119 9444958 9826708 | N/A | N/A | OmniPath |
MST1R | MET | 10490849 10506185 10871856 11064459 11741535 12475979 12766170 16782899 18836480 20016000 20726546 21777671 27898060 7513258 7687741 7731718 7838524 7961992 8547236 8906793 9242692 9391119 9444958 9826708 | stimulant | N/A | OmniPath |
PTPRB | MET | 16101282 21454675 27898060 | inhibition | N/A | OmniPath |
MET | GLMN | 11571281 27898060 | inhibition,stimulant | N/A | OmniPath |
MET | GRAP | 27898060 8662889 | stimulant | N/A | OmniPath |
MET | MAP4K1 | 11487585 15743830 27898060 | N/A | N/A | OmniPath |
MET | PLXNB3 | 15184888 15218527 27898060 | N/A | N/A | OmniPath |
PTPRJ | MET | 12370829 12475979 19167335 27898060 | inhibition | N/A | OmniPath |
MET | SPSB1 | 15713673 27898060 | N/A | N/A | OmniPath |