GENE：NPC1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NPC1 |
| FullNmae | NPC intracellular cholesterol transporter 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7897 |
| EnsembleID | ENSG00000141458 |
| Uniprot | O15118 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NPC1 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| NPC1 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| NPC1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NPC1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NPC1 | autophagy | 38042211 | NPC1 is highly expressed in HCC cells and tumor tissues, which promotes the proliferation, migration, and invasion of tumor cells by activating autophagy. | retulator signature |
| NPC1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NPC1 | GO:0001618,GO:0001889,GO:0004888,GO:0005515,GO:0005576,GO:0005635,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0006486,GO:0006897,GO:0006914,GO:0007041,GO:0007628,GO:0008203,GO:0008206,GO:0009410,GO:0010467,GO:0010878,GO:0012501,GO:0015248,GO:0015485,GO:0015485,GO:0016020,GO:0016236,GO:0016242,GO:0022008,GO:0030299,GO:0030301,GO:0031579,GO:0031902,GO:0032367,GO:0033344,GO:0038023,GO:0042632,GO:0042632,GO:0042632,GO:0042632,GO:0045121,GO:0046686,GO:0046718,GO:0048471,GO:0070062,GO:0071383,GO:0071404,GO:0090150,GO:1904036,GO:1904262,GO:2000900 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NPC1 | hsa:4864 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| NPC1 | hsa:4864 | path:hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NPC1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | NPC1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | NPC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | NPC1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000CBE63 | NPC1 | 20466885 23547260 | rna interference,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00000CBE63 | NPC1 | 20466885 23547260 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | NPC1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CAV1 | NPC1 | 24234451 25285302 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,confocal microscopy | ComPPI,IntAct |
| LGALS8 | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| NPC2 | NPC1 | 20674861 24234451 25348397 | physical association | anti tag coimmunoprecipitation,pull down | ComPPI,IntAct |
| VPS4A | NPC1 | 16757520 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| LRP6 | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO6 | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| PTPRK | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| OSBPL5 | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| TMOD3 | NPC1 | 25348397 | N/A | physical interaction | ComPPI |
| NPC1 | STING1 | 21903422 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NPC1 | UNC93B1 | 25348397 | N/A | physical interaction | ComPPI |
| NPC1 | MRPS28 | 25348397 | N/A | physical interaction | ComPPI |
| NPC1 | LGR4 | 25348397 | N/A | physical interaction | ComPPI |
| NPC1 | IL17RC | 25348397 | N/A | physical interaction | ComPPI |
| NPC1 | TPRA1 | 25348397 | N/A | physical interaction | ComPPI |
| HSCB | NPC1 | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| BUD31 | NPC1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| GPR35 | NPC1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| MC4R | NPC1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| STING1 | NPC1 | 21903422 27898060 | N/A | N/A | OmniPath |