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GENE：RUBCN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RUBCN
FullNmae rubicon autophagy regulator
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28991
EnsembleID ENSG00000145016
Uniprot Q92622

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RUBCN entotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RUBCN entotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
RUBCN autophagy 35282767 In this study, we found that fasting caused a substantial decrease in the adipose levels of RUBCN/rubicon, a negative regulator of macroautophagy/autophagy, along with an increase in autophagy. retulator signature
RUBCN autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RUBCN GO:0002376,GO:0005515,GO:0005654,GO:0005764,GO:0005769,GO:0005769,GO:0005770,GO:0005770,GO:0005829,GO:0006909,GO:0006914,GO:0010507,GO:0043231,GO:0043553,GO:0045806,GO:0045806,GO:0051898,GO:0071985,GO:1901097,GO:1901097,GO:1901097,GO:1901981

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RUBCN hsa:9711 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BECN1 RUBCN 19270696 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
TECPR1 RUBCN 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD9 RUBCN 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN CARD9 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN PIK3C3 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN CYBA 22423966 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN BECN1 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN CYBB 22423966 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN PIK3R4 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN UVRAG 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN YWHAB 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB
CYBA RUBCN 22423966 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
AR RUBCN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RUBCN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RUBCN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RUBCN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RUBCN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RUBCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032FC1A RUBCN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019F055 RUBCN 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006DA05 RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039607D RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F0F49 RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007D64A RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041CB9C RUBCN 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BYSL RUBCN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EXOC8 RUBCN 25348397 N/A physical interaction ComPPI
SMAD9 RUBCN 25348397 N/A two hybrid ComPPI
RUBCN BECN1 20562859 21062745 22493499 23954414 24034250 24234451 25348397 25594178 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
RUBCN PIK3C3 20562859 21062745 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
RUBCN UVRAG 20562859 21062745 22493499 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
RUBCN YWHAE 25348397 N/A physical interaction ComPPI
RUBCN EXOC1 25348397 N/A physical interaction ComPPI
RUBCN EXOC2 25348397 N/A physical interaction ComPPI
RUBCN PIK3R4 21062745 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RUBCN EGFR 24034250 24234451 25348397 25594178 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
RUBCN NME7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN DPF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN VEZF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN BRD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN FAM161A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN ZNF648 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN FAM9B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RUBCN GAS8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDIA4 RUBCN 24234451 30021884 physical association cross-linking study IntAct
H2BS1 RUBCN 24234451 30021884 physical association cross-linking study IntAct
RUBCN PIK3C3 19270693 19270696 20562859 21062745 22423967 24980960 27898060 inhibition N/A OmniPath
RUBCN BECN1 19270693 19270696 20562859 22423967 22493499 24980960 25594178 25891078 26496610 27898060 inhibition N/A OmniPath
CARD9 RUBCN 22423967 27898060 N/A N/A OmniPath

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