Gene Information gene info

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GENE：SIRT2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIRT2
FullNmae sirtuin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10886
EnsembleID ENSG00000068903
Uniprot Q8IXJ6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIRT2 mitotic_cd 30482390 These findings also suggest an undesirable function of the SIRT2 suppression associated with activation of the p53-p21 pathway in the suppression of mitotic cell death caused by spindle assembly checkpoint activation. retulator signature
SIRT2 autophagy 33481678 Sirtuin 2 (SIRT2) is known to modulate autophagy signaling, exerting effects in skeletal muscle atrophy. retulator signature
SIRT2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SIRT2 GO:0000122,GO:0000183,GO:0000781,GO:0000792,GO:0003682,GO:0003950,GO:0004407,GO:0005515,GO:0005634,GO:0005634,GO:0005677,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005829,GO:0005874,GO:0005886,GO:0006476,GO:0006476,GO:0006914,GO:0007084,GO:0007096,GO:0008134,GO:0008270,GO:0010507,GO:0010801,GO:0016575,GO:0017136,GO:0017136,GO:0021762,GO:0022011,GO:0030426,GO:0030496,GO:0031507,GO:0031509,GO:0031641,GO:0032436,GO:0033010,GO:0033270,GO:0033558,GO:0033558,GO:0034599,GO:0034979,GO:0034979,GO:0034979,GO:0034983,GO:0035035,GO:0040029,GO:0042177,GO:0042325,GO:0042826,GO:0042903,GO:0043130,GO:0043161,GO:0043204,GO:0043209,GO:0043219,GO:0043220,GO:0043388,GO:0044224,GO:0044242,GO:0044546,GO:0045087,GO:0045599,GO:0045723,GO:0045836,GO:0045843,GO:0045892,GO:0045944,GO:0046970,GO:0048471,GO:0051301,GO:0051321,GO:0051726,GO:0051775,GO:0051781,GO:0051987,GO:0061428,GO:0061433,GO:0070403,GO:0070403,GO:0070446,GO:0071456,GO:0071872,GO:0072686,GO:0072687,GO:0090042,GO:0090042,GO:0090042,GO:0097386,GO:0140297,GO:0140773,GO:0140774,GO:1900119,GO:1900195,GO:1900226,GO:2000378,GO:2000777

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIRT2 hsa:22933 path:hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human)
SIRT2 hsa:22933 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SIRT2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SIRT2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 SIRT2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SIRT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIRT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIRT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIRT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SIRT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 SIRT2 21801305 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 SIRT2 21801305 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D SIRT2 24161395 25416803 mrna cleavage,inhibition western blot TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 SIRT2 22135298 phosphorylation N/A PhosphoSite
CDK1 SIRT2 22135298 phosphorylation N/A PhosphoSite
CDK2 SIRT2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NUDT21 SIRT2 25348397 N/A physical interaction ComPPI
PPP1CB SIRT2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SNAI1 SIRT2 25348397 N/A physical interaction ComPPI
MOAP1 SIRT2 25348397 N/A physical interaction ComPPI
NUDT12 SIRT2 25348397 N/A physical interaction ComPPI
H4C1 SIRT2 25348397 N/A confocal microscopy ComPPI
CBL SIRT2 25348397 N/A physical interaction ComPPI
CBLB SIRT2 25348397 N/A physical interaction ComPPI
MYOD1 SIRT2 12887892 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
EP300 SIRT2 18722353 18995842 23934153 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KAT2B SIRT2 12887892 14525934 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct
FZR1 SIRT2 22014574 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGDIA SIRT2 25348397 N/A physical interaction ComPPI
BTRC SIRT2 25348397 N/A physical interaction ComPPI
ING1 SIRT2 25348397 N/A physical interaction ComPPI
MYC SIRT2 23217706 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TUBA4A SIRT2 12620231 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RELA SIRT2 21081649 24234451 25348397 deacetylation reaction,physical association anti bait coimmunoprecipitation,deacetylase assay ComPPI,IntAct
RAD51 SIRT2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XPO1 SIRT2 25348397 N/A physical interaction ComPPI
ORC2 SIRT2 25348397 N/A physical interaction ComPPI
MDM2 SIRT2 25348397 N/A physical interaction ComPPI
PAPOLA SIRT2 25348397 N/A physical interaction ComPPI
ODF2 SIRT2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CDK2 SIRT2 25348397 N/A physical interaction ComPPI
VAMP7 SIRT2 25348397 N/A physical interaction ComPPI
CDC20 SIRT2 22014574 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB2 SIRT2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SKP2 SIRT2 25348397 N/A physical interaction ComPPI
HDAC6 SIRT2 12620231 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
KAT2A SIRT2 12887892 14525934 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD
RAB3GAP2 SIRT2 25348397 N/A physical interaction ComPPI
RTN4 SIRT2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT2 CDC14B 12697818 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
SIRT2 HOXA10 14525934 15213244 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SIRT2 SPOP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT2 GYS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT2 KRT78 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT2 ELL 25348397 N/A physical interaction ComPPI
SIRT2 SARS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT2 DNAJB6 25348397 N/A physical interaction ComPPI
SIRT2 DNAJB8 25348397 N/A physical interaction ComPPI
SIRT2 RBP1 25348397 N/A physical interaction ComPPI
SIRT2 SIRT1 25348397 N/A physical interaction ComPPI
SIRT2 FOXO1 25348397 N/A physical interaction ComPPI
SIRT2 PCK1 25348397 N/A physical interaction ComPPI
SIRT2 RUNX3 25348397 N/A physical interaction ComPPI
SIRT2 ACLY 25348397 N/A physical interaction ComPPI
SIRT2 GPAM 25348397 N/A physical interaction ComPPI
SIRT2 RAB3GAP1 25348397 N/A physical interaction ComPPI
SIRT2 SCFD2 25348397 N/A physical interaction ComPPI
SIRT2 FADS1 25348397 N/A physical interaction ComPPI
SIRT2 MTDH 25348397 N/A physical interaction ComPPI
SIRT2 DEGS1 25348397 N/A physical interaction ComPPI
SIRT2 TRAPPC12 25348397 N/A physical interaction ComPPI
SIRT2 AHI1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 CEP89 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SIRT2 TINF2 25348397 N/A physical interaction ComPPI
SIRT2 GCKR 25348397 N/A physical interaction ComPPI
SIRT2 PLA2G4A 25348397 N/A physical interaction ComPPI
SIRT2 DMD 25348397 N/A physical interaction ComPPI
SIRT2 SLC22A23 25348397 N/A physical interaction ComPPI
SIRT2 GSTT1 25348397 N/A physical interaction ComPPI
SIRT2 GSTT2B 25348397 N/A physical interaction ComPPI
SIRT2 MANSC1 25348397 N/A physical interaction ComPPI
SIRT2 KIAA0930 25348397 N/A physical interaction ComPPI
SIRT2 CDC27 22014574 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SIRT2 G6PD 24234451 24769394 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
SIRT2 BUB1B 24234451 24825348 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SIRT2 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3C1 SIRT2 25348397 N/A physical interaction ComPPI
SOTV SIRT2 25348397 N/A two hybrid ComPPI
SIRT2 SP140 12887892 14525934 N/A experimental interaction detection HPRD
OXTR SIRT2 24234451 28298427 physical association ubiquitin reconstruction IntAct
MAPT SIRT2 24234451 26402096 association anti bait coimmunoprecipitation IntAct
SIRT2 MYOD1 12887892 27898060 inhibition N/A OmniPath
CDK2 SIRT2 18332217 26303530 27898060 inhibition N/A OmniPath
SIRT2 FOXO1 15220471 17684529 20543840 24419059 27898060 inhibition,stimulant N/A OmniPath
SIRT2 H3C1 19270680 19801601 27898060 inhibition N/A OmniPath
CDK1 SIRT2 17488717 17516032 18332217 27898060 inhibition N/A OmniPath
CDC14B SIRT2 12697818 17488717 27898060 N/A N/A OmniPath
SIRT2 KAT2B 12887892 27898060 inhibition N/A OmniPath
SIRT2 TUBA4A 12620231 27898060 N/A N/A OmniPath
PRKAA1 SIRT2 24446434 27898060 N/A N/A OmniPath
CDC14A SIRT2 17488717 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B255B SIRT2 27087310 direct interaction,inhibition N/A NPInter

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