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GENE：EPHB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EPHB2
FullNmae EPH receptor B2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3393
EnsembleID ENSG00000133216
Uniprot P29323

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EPHB2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EPHB2 GO:0001525,GO:0001540,GO:0001540,GO:0001655,GO:0001933,GO:0002639,GO:0004713,GO:0005005,GO:0005005,GO:0005005,GO:0005102,GO:0005515,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006468,GO:0006469,GO:0007162,GO:0007399,GO:0007411,GO:0007411,GO:0007413,GO:0007611,GO:0007612,GO:0008046,GO:0009986,GO:0010628,GO:0016310,GO:0018108,GO:0021631,GO:0021934,GO:0021952,GO:0022038,GO:0030193,GO:0030335,GO:0030424,GO:0030425,GO:0030425,GO:0030890,GO:0031290,GO:0031915,GO:0032760,GO:0042113,GO:0042472,GO:0042734,GO:0042802,GO:0043025,GO:0043197,GO:0044877,GO:0045211,GO:0046425,GO:0046580,GO:0048013,GO:0048013,GO:0048168,GO:0048170,GO:0048593,GO:0050771,GO:0050878,GO:0051489,GO:0051965,GO:0060021,GO:0060996,GO:0060997,GO:0061003,GO:0070373,GO:0071222,GO:0071679,GO:0097104,GO:0098686,GO:0098794,GO:0098978,GO:0099557,GO:0106028,GO:0110077,GO:0120192,GO:1900016,GO:1900273,GO:1903078,GO:1904646,GO:1904782,GO:1904783,GO:2000010,GO:2000316,GO:2000785,GO:2000822

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EPHB2 hsa:2048 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EFNB2 EPHB2 11780069 23331499 9267020 stimulation N/A SignaLink
EFNB1 EPHB2 23331499 9576626 stimulation N/A SignaLink
EPHB2 SRC 10644995 18713744 23331499 9632142 stimulation N/A SignaLink
EPHB2 RASA1 10644995 23331499 9233798 stimulation N/A SignaLink
EPHB2 ABL1 11494128 23331499 stimulation N/A SignaLink
ABL1 EPHB2 11494128 23331499 stimulation N/A SignaLink
EPHB2 SYNJ1 15821731 23331499 stimulation N/A SignaLink
EPHB2 ITSN1 12389031 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CRK EPHB2 20005715 interaction type N/A PSP,SignaLink
GRB2 EPHB2 20005715 interaction type N/A PSP,SignaLink
AFDN EPHB2 20005715 interaction type N/A PSP,SignaLink
NCK1 EPHB2 20005715 interaction type N/A PSP,SignaLink
SDCBP EPHB2 20005715 interaction type N/A PSP
SDCBP EPHB2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR EPHB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
REL EPHB2 19621336 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SMARCA4 EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EPHB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BTF3 EPHB2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A2 EPHB2 17312387 trascriptional regulation,stimulation inferred by curator TFlink
BTN3A3 EPHB2 17312387 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA EPHB2 24803159 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000075A760 EPHB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 EPHB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D EPHB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB EPHB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 EPHB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 EPHB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 EPHB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A EPHB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCDA3 EPHB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048F59D EPHB2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EPHB2 RRAS 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
NCK1 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 NCK1 25361965 interaction type N/A PTMCode2
SDC2 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 SDC2 25361965 interaction type N/A PTMCode2
ARHGEF6 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 ARHGEF6 25361965 interaction type N/A PTMCode2
EFNB2 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 EFNB2 25361965 interaction type N/A PTMCode2
EFNA5 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 EFNA5 25361965 interaction type N/A PTMCode2
MMP2 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 MMP2 25361965 interaction type N/A PTMCode2
EFNB1 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 EFNB1 25361965 interaction type N/A PTMCode2
SRC EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 SRC 25361965 interaction type N/A PTMCode2
KALRN EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 KALRN 25361965 interaction type N/A PTMCode2
RRAS EPHB2 25361965 interaction type N/A PTMCode2
ABL1 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 ABL1 25361965 interaction type N/A PTMCode2
FOS EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 FOS 25361965 interaction type N/A PTMCode2
GRB2 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 GRB2 25361965 interaction type N/A PTMCode2
CRK EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 CRK 25361965 interaction type N/A PTMCode2
YES1 EPHB2 25361965 interaction type N/A PTMCode2
EPHB2 YES1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YES1 EPHB2 25348397 N/A physical interaction ComPPI
CRK EPHB2 25348397 N/A physical interaction ComPPI
PICK1 EPHB2 10839360 14525934 25348397 9883737 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
VAV2 EPHB2 14525934 15848800 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC EPHB2 14525934 18713744 25348397 9632142 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
VEGFA EPHB2 14525934 17318185 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RRAS EPHB2 10570155 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NCK1 EPHB2 14525934 25348397 9233798 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHB2 AQP1 25348397 N/A two hybrid,in vivo ComPPI
EPHB2 EFNB1 14525934 25348397 8878483 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHB2 EFNB2 11780069 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EPHB2 ITSN1 12389031 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EPHB2 ERF 10330152 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHB2 GRIN1 11754835 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 EFNA5 14525934 15107857 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 SYNJ1 14525934 15821731 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 SH2D3C 10542222 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 GRIN2B 11799243 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHB2 SDC2 11580899 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHB2 KALRN 12546821 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 ARHGEF6 10523848 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 GRB2 14525934 16298995 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHB2 SDCBP 14525934 25348397 9883737 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
EPHB2 KSR1 11940661 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHB2 MMP2 14525934 18713744 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHB2 MMP9 14525934 18713744 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHB2 RASA1 10644995 14525934 25348397 9233798 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EPHB2 ABL2 11494128 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EPHB2 ACP1 14525934 25348397 9499402 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EPHB2 RYK 11956217 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EPHB2 AFDN 24234451 25348397 9707552 physical association two hybrid,physical interaction ComPPI,IntAct
EPHB2 PLCG1 25348397 N/A physical interaction ComPPI
EPHB2 ABL1 11494128 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
EPHB2 ALK 25348397 N/A physical interaction ComPPI
EPHB2 SPSB2 25348397 N/A physical interaction ComPPI
EPHB2 KDM4A 25348397 N/A physical interaction ComPPI
EPHB2 MTMR14 25348397 N/A physical interaction ComPPI
EPHB2 RBL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EPHB2 PTP4A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EPHB2 MAPK14 25348397 N/A imaging technique ComPPI
EPHB2 NUP153 17255949 24234451 25348397 physical association pull down ComPPI,IntAct
HMMR EPHB2 25348397 N/A physical interaction ComPPI
EPHB2 EPHB2 10572014 14525934 17192257 9233798 9632142 N/A experimental interaction detection HPRD
EPHB2 FOS 12972619 14525934 7816602 N/A experimental interaction detection HPRD
EPHB2 SRC 10644995 18713744 27898060 9632142 stimulant N/A OmniPath
BTF3 EPHB2 17312387 27898060 stimulant N/A OmniPath
ABL1 EPHB2 11494128 27898060 inhibition N/A OmniPath
EPHB2 RRAS 10570155 27898060 inhibition,stimulant N/A OmniPath
EPHB2 RASA1 10644995 27898060 9233798 stimulant N/A OmniPath
EPHB2 EFNB2 11780069 12606549 15096211 26186194 27898060 stimulant N/A OmniPath
EFNB1 EPHB2 27898060 8878483 9330863 N/A N/A OmniPath
EPHB2 SYNJ1 15821731 27898060 inhibition,stimulant N/A OmniPath
PTPRO EPHB2 16680165 27898060 N/A N/A OmniPath

Visualization










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