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GENE：SREBF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SREBF2
FullNmae sterol regulatory element binding transcription factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11290
EnsembleID ENSG00000198911
Uniprot Q12772

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SREBF2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SREBF2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SREBF2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SREBF2 GO:0000122,GO:0000139,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001227,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006629,GO:0008203,GO:0008593,GO:0009267,GO:0010886,GO:0010886,GO:0012507,GO:0032933,GO:0032933,GO:0032937,GO:0042632,GO:0043231,GO:0045542,GO:0045944,GO:0045944,GO:0046983,GO:0070888,GO:0071404,GO:0071499,GO:0090370,GO:1902895,GO:1903146,GO:1903955,GO:1990837

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK1 SREBF2 10627507 14988395 23180781 phosphorylation reaction protein kinase assay InnateDB
SREBF2 MAPK3 10627507 14988395 23180781 phosphorylation reaction protein kinase assay InnateDB
SREBF2 NPC1L1 20460578 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G6 SREBF2 15450207 23180781 physical association electrophoretic mobility shift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR SREBF2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 SREBF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SREBF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SREBF2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SREBF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARA SREBF2 16946405 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SREBF2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D SREBF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC SREBF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001799A3 SREBF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 SREBF2 23951060 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002367FA SREBF2 23592263 23951060 25416803 25914460 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00005CCD18 SREBF2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED SREBF2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003E2232 SREBF2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 SREBF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B SREBF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D SREBF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006097A6 SREBF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032D69B SREBF2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 SREBF2 22135298 phosphorylation N/A PhosphoSite
MAPK1 SREBF2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIAS2 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
UBE2I SREBF2 12615929 14525934 20936779 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
FHL3 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ATXN1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MRPS6 SREBF2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
INSIG2 SREBF2 12242332 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK1 SREBF2 10627507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ZYX SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SP1 SREBF2 10976766 14525934 20936779 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid pooling approach,in vitro ComPPI,HPRD,IntAct
ARHGEF1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CASP3 SREBF2 14525934 25348397 27898060 8605870 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
MAPK3 SREBF2 10627507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NFYA SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CREBBP SREBF2 14525934 16799563 24234451 25348397 8918891 association,physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SUMO1 SREBF2 12615929 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EP300 SREBF2 14525934 25348397 8918891 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 SREBF2 14525934 15527767 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COPS5 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HDAC3 SREBF2 25348397 N/A physical interaction ComPPI
PIAS1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FHL2 SREBF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTH1R SREBF2 25348397 N/A physical interaction ComPPI
KPNB1 SREBF2 10397761 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MED1 SREBF2 16799563 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CDH5 SREBF2 25348397 N/A physical interaction ComPPI
HSPA5 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HNRNPL SREBF2 25348397 N/A physical interaction ComPPI
SREBF1 SREBF2 25348397 N/A physical interaction ComPPI
SREBF2 HNF4A 12855700 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct,OmniPath
SREBF2 SCAP 10896675 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SREBF2 INSIG1 12242332 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SREBF2 RAB11B 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SREBF2 ARRB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 EGR1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 GOLGB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 ITGB4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 ABLIM1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 PSMD4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 SPTBN1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 CREB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 ZMYM2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 SLC4A4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 CASP8AP2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 PIAS3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 OS9 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 ZDHHC17 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 ATF7IP 25348397 N/A physical interaction ComPPI
SREBF2 ABLIM2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SREBF2 KLF13 25348397 N/A physical interaction ComPPI
SREBF2 ATF6 25348397 N/A physical interaction ComPPI
SREBF2 RNF139 25348397 N/A physical interaction ComPPI
SREBF2 HINFP 25348397 N/A physical interaction ComPPI
SREBF2 NPAT 25348397 N/A physical interaction ComPPI
SREBF2 TRRAP 25348397 N/A physical interaction ComPPI
SREBF2 PARK7 25348397 N/A physical interaction ComPPI
SREBF2 NAE1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SREBF2 ERLIN2 25348397 N/A physical interaction ComPPI
SREBF2 SPINT2 25348397 N/A physical interaction ComPPI
SREBF2 HLA-DPA1 25348397 N/A physical interaction ComPPI
SREBF2 NRG1 25348397 N/A physical interaction ComPPI
SREBF2 CGRRF1 25348397 N/A physical interaction ComPPI
SREBF2 SLC39A4 25348397 N/A physical interaction ComPPI
SREBF2 AURKA 25348397 N/A physical interaction ComPPI
SREBF2 ZNRF4 25348397 N/A physical interaction ComPPI
SREBF2 TMCO3 25348397 N/A physical interaction ComPPI
SREBF2 DKK3 25348397 N/A physical interaction ComPPI
SREBF2 CHRND 25348397 N/A physical interaction ComPPI
SREBF2 IL17RC 25348397 N/A physical interaction ComPPI
SREBF2 CD79B 25348397 N/A physical interaction ComPPI
SREBF2 SLC4A8 25348397 N/A physical interaction ComPPI
SREBF2 SLC39A12 25348397 N/A physical interaction ComPPI
SREBF2 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
SREBF2 MED6 16799563 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SREBF2 MED15 16799563 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
SREBF2 CDK8 16799563 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SREBF2 TP53 22265415 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,cross-linking study ComPPI,IntAct,OmniPath
SREBF2 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
SREBF2 NR1H4 24234451 24321096 25348397 27898060 physical association pull down ComPPI,IntAct,OmniPath
TTC1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
LZTR1 SREBF2 25348397 N/A physical interaction ComPPI
SREBF2 SREBF2 11283257 14525934 N/A experimental interaction detection HPRD
CASP1 SREBF2 16990137 27898060 stimulant N/A OmniPath
MAPK3 SREBF2 10627507 14988395 27898060 stimulant N/A OmniPath
MAPK1 SREBF2 10627507 14988395 18403372 27898060 stimulant N/A OmniPath

Visualization










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