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GENE：TPCN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPCN2
FullNmae two pore segment channel 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20820
EnsembleID ENSG00000162341
Uniprot Q8NHX9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPCN2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPCN2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TPCN2 GO:0005245,GO:0005262,GO:0005515,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005829,GO:0006874,GO:0006939,GO:0007040,GO:0010008,GO:0010506,GO:0015280,GO:0015280,GO:0017157,GO:0019065,GO:0019722,GO:0019722,GO:0019901,GO:0031902,GO:0033162,GO:0033280,GO:0034220,GO:0034765,GO:0035725,GO:0036020,GO:0042802,GO:0042802,GO:0048086,GO:0051209,GO:0051452,GO:0072345,GO:0072345,GO:0075509,GO:0075509,GO:0080025,GO:0090117,GO:0097682,GO:0097682

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPCN2 hsa:219931 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
TPCN2 hsa:219931 path:hsa04972 Pancreatic secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TPCN2 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TPCN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TPCN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TPCN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TPCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003A5E54 TPCN2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 TPCN2 19536157 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005485E8 TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A TPCN2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC TPCN2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 TPCN2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000759F6E TPCN2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004C689A TPCN2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 TPCN2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 TPCN2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
VAMP2 TPCN2 25348397 N/A physical interaction ComPPI
APPL1 TPCN2 25348397 N/A physical interaction ComPPI
SNX17 TPCN2 25348397 N/A physical interaction ComPPI
HAX1 TPCN2 24188827 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
PTPRA TPCN2 25348397 N/A physical interaction ComPPI
HNRNPL TPCN2 25348397 N/A physical interaction ComPPI
ANKRD27 TPCN2 25348397 N/A physical interaction ComPPI
ARRB2 TPCN2 25348397 N/A physical interaction ComPPI
FGFR1 TPCN2 25348397 N/A physical interaction ComPPI
VAMP3 TPCN2 25348397 N/A physical interaction ComPPI
OCRL TPCN2 25348397 N/A physical interaction ComPPI
AP3D1 TPCN2 25348397 N/A physical interaction ComPPI
EBP TPCN2 25348397 N/A physical interaction ComPPI
AP3B1 TPCN2 25348397 N/A physical interaction ComPPI
MAP2K7 TPCN2 25348397 N/A physical interaction ComPPI
WDR44 TPCN2 25348397 N/A physical interaction ComPPI
TRIM25 TPCN2 25348397 N/A physical interaction ComPPI
CLCN3 TPCN2 25348397 N/A physical interaction ComPPI
BMPR1A TPCN2 25348397 N/A physical interaction ComPPI
MTOR TPCN2 23394946 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
DIP2A TPCN2 25348397 N/A physical interaction ComPPI
AP3S1 TPCN2 25348397 N/A physical interaction ComPPI
NDFIP1 TPCN2 25348397 N/A physical interaction ComPPI
STX6 TPCN2 25348397 N/A physical interaction ComPPI
CSNK1G3 TPCN2 25348397 N/A physical interaction ComPPI
RAB6B TPCN2 25348397 N/A physical interaction ComPPI
RRAGB TPCN2 25348397 N/A physical interaction ComPPI
NOMO1 TPCN2 25348397 N/A physical interaction ComPPI
HK3 TPCN2 25348397 N/A physical interaction ComPPI
RELT TPCN2 25348397 N/A physical interaction ComPPI
DAGLB TPCN2 25348397 N/A physical interaction ComPPI
LRP10 TPCN2 25348397 N/A physical interaction ComPPI
PI4K2A TPCN2 25348397 N/A physical interaction ComPPI
UXS1 TPCN2 25348397 N/A physical interaction ComPPI
EHD4 TPCN2 25348397 N/A physical interaction ComPPI
PTPRD TPCN2 25348397 N/A physical interaction ComPPI
USP32 TPCN2 25348397 N/A physical interaction ComPPI
WDR11 TPCN2 25348397 N/A physical interaction ComPPI
TRAPPC8 TPCN2 25348397 N/A physical interaction ComPPI
ACP2 TPCN2 25348397 N/A physical interaction ComPPI
NOMO3 TPCN2 25348397 N/A physical interaction ComPPI
PCDH9 TPCN2 25348397 N/A physical interaction ComPPI
RNF149 TPCN2 25348397 N/A physical interaction ComPPI
TLCD4 TPCN2 25348397 N/A physical interaction ComPPI
B4GALT5 TPCN2 25348397 N/A physical interaction ComPPI
ZRANB3 TPCN2 25348397 N/A physical interaction ComPPI
FBXO10 TPCN2 25348397 N/A physical interaction ComPPI
TRAPPC5 TPCN2 25348397 N/A physical interaction ComPPI
CERK TPCN2 25348397 N/A physical interaction ComPPI
CD320 TPCN2 25348397 N/A physical interaction ComPPI
DENND6A TPCN2 25348397 N/A physical interaction ComPPI
TPCN1 TPCN2 21903581 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,fluorescence microscopy ComPPI,IntAct,OmniPath
ZDHHC18 TPCN2 25348397 N/A physical interaction ComPPI
TSR3 TPCN2 25348397 N/A physical interaction ComPPI
AGBL5 TPCN2 25348397 N/A physical interaction ComPPI
TPCN2 TPCN2 21903581 24234451 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer IntAct
ADRA1A TPCN2 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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