Gene Information gene info

  1. Home

GENE：TRIM21

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRIM21
FullNmae tripartite motif containing 21
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11312
EnsembleID ENSG00000132109
Uniprot P19474

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRIM21 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIM21 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIM21 autophagy 38783335 NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21. retulator signature
TRIM21 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TRIM21 GO:0000209,GO:0000209,GO:0000932,GO:0003677,GO:0003713,GO:0003723,GO:0004842,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005776,GO:0005829,GO:0005829,GO:0006513,GO:0007049,GO:0008270,GO:0010498,GO:0010508,GO:0010508,GO:0016567,GO:0019901,GO:0031410,GO:0031648,GO:0032088,GO:0032092,GO:0032479,GO:0032880,GO:0032897,GO:0034341,GO:0042802,GO:0042803,GO:0043123,GO:0044790,GO:0045087,GO:0045087,GO:0045787,GO:0045824,GO:0045893,GO:0046596,GO:0046598,GO:0051091,GO:0051092,GO:0051865,GO:0061630,GO:0061630,GO:0061630,GO:0062197,GO:0070269,GO:0070534,GO:0090086,GO:1990904

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRIM21 hsa:6737 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRIM21 CUL1 16880511 23180781 physical association anti tag coimmunoprecipitation InnateDB
SKP2 TRIM21 16880511 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM21 IRF3 18641315 19265157 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IRF7 TRIM21 18641315 20668674 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TRIM21 FADD 21183682 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD TRIM21 21183682 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM21 IRF8 22096565 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TRIM21 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ZNF263 TRIM21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TRIM21 23391827 trascriptional regulation,stimulation inferred by curator TFlink
RELA TRIM21 23391827 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000279B6F TRIM21 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB TRIM21 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 TRIM21 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 TRIM21 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF TRIM21 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SKP1 TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 SKP1 25361965 interaction type N/A PTMCode2
TRIM21 CBL 25361965 interaction type N/A PTMCode2
CBL TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 FBXW11 25361965 interaction type N/A PTMCode2
FBXW11 TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 USP4 25361965 interaction type N/A PTMCode2
USP4 TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 IRF8 25361965 interaction type N/A PTMCode2
IRF8 TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 SKP2 25361965 interaction type N/A PTMCode2
SKP2 TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 CALR 25361965 interaction type N/A PTMCode2
CALR TRIM21 25361965 interaction type N/A PTMCode2
TRIM21 CUL1 25361965 interaction type N/A PTMCode2
CUL1 TRIM21 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GMCL1 TRIM21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NMI TRIM21 25348397 N/A physical interaction ComPPI
UBE2I TRIM21 25348397 N/A physical interaction ComPPI
CDC5L TRIM21 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YJU2 TRIM21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DAXX TRIM21 20697732 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM21 IGHG1 17400754 25348397 25416956 27898060 N/A two hybrid ComPPI,OmniPath
TRIM21 GRAP 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM21 TXN2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM21 USP4 11461834 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TRIM21 RO60 11251884 14525934 16219770 21307595 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
TRIM21 NIF3L1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TRIM21 YWHAZ 14525934 15324660 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRIM21 NCOA1 25348397 N/A physical interaction ComPPI
TRIM21 NCOA3 25348397 N/A physical interaction ComPPI
TRIM21 IRF8 25348397 N/A physical interaction ComPPI
TRIM21 USP19 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 SKP2 25348397 N/A physical interaction ComPPI
TRIM21 CUL1 25348397 N/A physical interaction ComPPI
TRIM21 SKP1 25348397 N/A physical interaction ComPPI
TRIM21 FBXW11 25348397 N/A physical interaction ComPPI
TRIM21 CDKN1B 25348397 N/A physical interaction ComPPI
TRIM21 APC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TRIM21 HDAC1 25348397 N/A physical interaction ComPPI
TRIM21 IRF3 25348397 N/A physical interaction ComPPI
TRIM21 FADD 25348397 N/A physical interaction ComPPI
TRIM21 AGO3 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 AGO4 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 IKBKB 25348397 N/A physical interaction ComPPI
TRIM21 HLA-DRB1 25348397 N/A physical interaction ComPPI
TRIM21 SQSTM1 25348397 N/A physical interaction ComPPI
TRIM21 YWHAG 15324660 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 IRF7 25348397 N/A physical interaction ComPPI
TRIM21 ERG 25348397 N/A physical interaction ComPPI
TRIM21 CASP8AP2 25348397 N/A physical interaction ComPPI
TRIM21 CDK2 25348397 N/A physical interaction ComPPI
TRIM21 ZFPM1 25348397 N/A physical interaction ComPPI
TRIM21 CD52 25348397 N/A physical interaction ComPPI
TRIM21 FCGR2A 25348397 N/A physical interaction ComPPI
TRIM21 TRIM5 25348397 N/A physical interaction ComPPI
TRIM21 DCP2 18361920 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM21 CBL 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRIM21 UBE2D1 17579016 21045130 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM21 UBE2H 25348397 N/A physical interaction ComPPI
TRIM21 UBE2D2 16297862 16403452 16472766 19675099 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM21 UBE2L3 25348397 N/A physical interaction ComPPI
TRIM21 UBE2C 25348397 N/A physical interaction ComPPI
TRIM21 CDC34 25348397 N/A physical interaction ComPPI
TRIM21 USP2 25348397 N/A physical interaction ComPPI
TRIM21 USP15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM21 VCP 25348397 N/A physical interaction ComPPI
TRIM21 MYC 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TRIM21 ROR1 23153538 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 UBC 25348397 N/A physical interaction ComPPI
TRIM21 NOS2 25348397 N/A physical interaction ComPPI
TRIM21 PAN2 25348397 N/A physical interaction ComPPI
TRIM21 NPM1 25348397 N/A physical interaction ComPPI
TRIM21 TRIM39 22493164 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TRIM21 RNF111 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 DZIP3 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 TRIM27 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 RBCK1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 MNAT1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 TRIM8 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM21 FBXO6 25348397 N/A physical interaction ComPPI
TRIM21 HAUS2 25348397 N/A physical interaction ComPPI
TRIM21 IRF5 25084355 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM21 H3C1 25348397 N/A physical interaction ComPPI
TRIM21 PFKFB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 ULK1 25348397 N/A physical interaction ComPPI
TRIM21 BECN1 25348397 N/A physical interaction ComPPI
TRIM21 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 MAP1LC3B 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 MAP1LC3C 25348397 N/A physical interaction ComPPI
TRIM21 GABARAP 25348397 N/A physical interaction ComPPI
TRIM21 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 GABARAPL2 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM21 GAN 25348397 N/A physical interaction ComPPI
TRIM21 PRMT5 25348397 N/A physical interaction ComPPI
TRIM21 IFI35 25348397 N/A physical interaction ComPPI
TRIM21 NF2 25348397 N/A physical interaction ComPPI
TRIM21 CALR 25348397 27898060 8666824 N/A physical interaction ComPPI,OmniPath
TRIM21 DPPA4 25348397 N/A physical interaction ComPPI
TRIM21 NANOGP8 25348397 N/A physical interaction ComPPI
TRIM21 NANOG 25348397 N/A physical interaction ComPPI
TRIM21 GMPS 25348397 N/A physical interaction ComPPI
TRIM21 RC3H1 25348397 N/A physical interaction ComPPI
TRIM21 BAG6 25348397 N/A physical interaction ComPPI
TRIM21 CRBN 25348397 N/A physical interaction ComPPI
TRIM21 FAIM2 25348397 N/A physical interaction ComPPI
TRIM21 CYLD 25348397 N/A physical interaction ComPPI
TRIM21 G3BP1 25348397 N/A physical interaction ComPPI
TRIM21 DCAF4L2 25348397 N/A physical interaction ComPPI
TRIM21 HDAC6 25348397 N/A physical interaction ComPPI
TRIM21 CFTR 25348397 N/A physical interaction ComPPI
TRIM21 PAWR 25348397 N/A physical interaction ComPPI
TRIM21 CREBBP 11971985 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
TRIM21 TNNI3 11461834 24234451 25348397 physical association two hybrid ComPPI,IntAct
TRIM21 EEF1D 11461834 24234451 25348397 physical association two hybrid ComPPI,IntAct
TRIM21 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM21 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
TRIM21 UBA1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
TRIM21 UBE2N 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
TRIM21 CBX4 25348397 N/A two hybrid ComPPI
TRIM21 CWC25 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 ZBTB16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 EXOC8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 FHOD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 ALOX15B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 EHHADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 TRIM3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 TNS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 TCP11L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 VPS9D1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 XAF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 DMAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM21 TRIM21 11331580 14525934 22493164 22829933 24234451 25416956 physical association anti tag coimmunoprecipitation,two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid HPRD,IntAct
PABPC1 TRIM21 11279042 27898060 N/A N/A OmniPath
TRIM21 FCGR2B 18420815 27898060 N/A N/A OmniPath
FBP1 TRIM21 20513352 27898060 N/A N/A OmniPath
TRIM21 SGTB 17441508 20850366 21619481 21832041 27898060 N/A N/A OmniPath
FADD TRIM21 21183682 27898060 N/A N/A OmniPath
IRF3 TRIM21 18641315 19265157 22479513 27898060 N/A N/A OmniPath
TRIM21 IRF7 18641315 20668674 27898060 N/A N/A OmniPath
TRIM21 GMPS 24462112 27898060 inhibition N/A OmniPath

Visualization










  Return