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GENE：TSPO

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TSPO
FullNmae translocator protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1158
EnsembleID ENSG00000100300
Uniprot B1AH88|P30536

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TSPO mpt 26688086 The mitochondrial translocator protein (TSPO) is a high affinity cholesterol binding protein which is primarily located in the outer mitochondrial membrane where it has been shown to interact with proteins implicated in mitochondrial permeability transition pore (mPTP) formation. retulator signature
TSPO immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TSPO autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TSPO autophagy 37717810 In contrast, inhibition of TSPO prevented autophagy over-activation both in vivo and in vitro. retulator signature
TSPO autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TSPO GO:0005497,GO:0005515,GO:0005739,GO:0005741,GO:0005783,GO:0005829,GO:0006626,GO:0006700,GO:0006783,GO:0006820,GO:0006821,GO:0008202,GO:0008347,GO:0008503,GO:0009410,GO:0010042,GO:0010266,GO:0014012,GO:0015485,GO:0015485,GO:0015918,GO:0030325,GO:0031397,GO:0032374,GO:0032570,GO:0032720,GO:0033574,GO:0042127,GO:0042632,GO:0043065,GO:0043231,GO:0044325,GO:0045019,GO:0048266,GO:0050810,GO:0051901,GO:0051928,GO:0060242,GO:0060252,GO:0060253,GO:0062100,GO:0070062,GO:0071222,GO:0071294,GO:0071476,GO:0072656,GO:0120009,GO:0120020,GO:1903147,GO:1903579,GO:1905144,GO:2000379,GO:2000853

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TSPO hsa:706 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
TSPO hsa:706 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)
TSPO hsa:706 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPID TSPO 15033708 17568748 18309324 20080742 20823910 21887410 25486353 26192618 interaction type N/A ACSN
TSPO CREB3L1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR TSPO 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
ATP5PO TSPO 25348397 N/A physical interaction ComPPI
PVR TSPO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VDAC1 TSPO 25348397 N/A physical interaction ComPPI
VDAC2 TSPO 25348397 N/A physical interaction ComPPI
ARF4 TSPO 25348397 N/A physical interaction ComPPI
KCNF1 TSPO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RRP1B TSPO 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TSPOAP1 TSPO 14525934 25348397 27898060 9915832 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
AMIGO1 TSPO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATP5F1A TSPO 25348397 N/A physical interaction ComPPI
ICAM3 TSPO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VDAC3 TSPO 25348397 N/A physical interaction ComPPI
CRABP1 TSPO 25348397 N/A physical interaction ComPPI
TMEM9 TSPO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATP5MG TSPO 25348397 N/A physical interaction ComPPI
CREB3L1 TSPO 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATP5PB TSPO 25348397 N/A physical interaction ComPPI
TSPO CISD1 25348397 N/A physical interaction ComPPI
TSPO SLC2A12 25348397 N/A physical interaction ComPPI
TSPO SLC5A8 25348397 N/A physical interaction ComPPI
TSPO LYPD5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSPO NCR3LG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSPO FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSPO CLEC10A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSPO LEUTX 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSPO DBI 14525934 27898060 7626442 N/A experimental interaction detection HPRD,OmniPath

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