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GENE：UCHL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UCHL1
FullNmae ubiquitin C-terminal hydrolase L1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12513
EnsembleID ENSG00000154277
Uniprot P09936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UCHL1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UCHL1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
UCHL1 GO:0002176,GO:0002931,GO:0004197,GO:0004843,GO:0004843,GO:0004843,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005737,GO:0005789,GO:0005829,GO:0005829,GO:0005886,GO:0007412,GO:0007628,GO:0008242,GO:0016241,GO:0016579,GO:0016579,GO:0019896,GO:0031625,GO:0031694,GO:0042755,GO:0043025,GO:0043130,GO:0043161,GO:0043407,GO:0044306,GO:0050905,GO:0055001,GO:0071466,GO:1904115

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UCHL1 hsa:7345 path:hsa05012 Parkinson disease - Homo sapiens (human)
UCHL1 hsa:7345 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP UCHL1 16049941 23180781 physical association anti tag coimmunoprecipitation InnateDB
NMRAL1 UCHL1 23180781 24763515 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 UCHL1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 UCHL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
REST UCHL1 17823282 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 UCHL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UCHL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB UCHL1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC UCHL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D UCHL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 UCHL1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TP53 UCHL1 25361965 interaction type N/A PTMCode2
UCHL1 TP53 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I UCHL1 12082530 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EIF1B UCHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSPA8 UCHL1 14525934 18550537 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KRT4 UCHL1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT1 UCHL1 24234451 25348397 26966684 association pull down ComPPI,IntAct
CDK6 UCHL1 25348397 N/A physical interaction ComPPI
CDKN1B UCHL1 12082530 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct
TRAF6 UCHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMN1 UCHL1 20713032 25348397 27898060 N/A physical interaction ComPPI,OmniPath
AIM2 UCHL1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
CBX1 UCHL1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COPS5 UCHL1 12082530 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CDKN2A UCHL1 25348397 N/A physical interaction ComPPI
UBB UCHL1 16169070 24234451 25348397 physical association two hybrid,molecular sieving,x-ray crystallography,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,protease assay,protein cleavage,comigration in sds page ComPPI,IntAct
UBC UCHL1 25348397 N/A two hybrid,molecular sieving,x-ray crystallography,physical interaction,physical interaction,protease assay,protein cleavage,comigration in sds page ComPPI
RPS27A UCHL1 25348397 N/A two hybrid,molecular sieving,x-ray crystallography,physical interaction,protease assay,protein cleavage,comigration in sds page ComPPI
UBA52 UCHL1 25348397 N/A two hybrid,molecular sieving,x-ray crystallography,physical interaction,protease assay,protein cleavage,comigration in sds page ComPPI
HSP90AA1 UCHL1 14525934 18550537 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PLA2G2A UCHL1 25348397 N/A physical interaction ComPPI
NTRK1 UCHL1 25348397 N/A physical interaction ComPPI
TRAF3 UCHL1 25348397 N/A physical interaction ComPPI
TNFRSF1A UCHL1 25348397 N/A physical interaction ComPPI
EIF6 UCHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RANBP9 UCHL1 12082530 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TNIK UCHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPS6 UCHL1 24234451 25348397 29568061 association pull down ComPPI,IntAct
NEDD8 UCHL1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MDM2 UCHL1 25348397 N/A physical interaction ComPPI
CDK2 UCHL1 25348397 N/A physical interaction ComPPI
ADRB2 UCHL1 25348397 N/A physical interaction ComPPI
EGFR UCHL1 20029029 24234451 25348397 physical association anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
TUBA1A UCHL1 18250096 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VHL UCHL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM63 UCHL1 25348397 N/A physical interaction ComPPI
CTNNB1 UCHL1 25348397 N/A physical interaction ComPPI
UCHL1 LAMP2 14525934 18550537 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UCHL1 TP53 18666234 20395212 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UCHL1 KRT17 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 CCDC14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 CDKN2A 25348397 N/A physical interaction ComPPI
UCHL1 TERF2IP 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
UCHL1 TINF2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
UCHL1 HSP90AA2P 25348397 N/A physical interaction ComPPI
UCHL1 ADRA2A 19477270 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UCHL1 ADRA2B 25348397 N/A physical interaction ComPPI
UCHL1 ADRA2C 25348397 N/A physical interaction ComPPI
UCHL1 AKT1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UCHL1 NCAM1 23061666 24234451 25348397 27898060 N/A protein array,physical interaction ComPPI,IntAct,OmniPath
UCHL1 TRIM54 25348397 N/A physical interaction ComPPI
UCHL1 USP15 25348397 N/A physical interaction ComPPI
UCHL1 USP28 25348397 N/A physical interaction ComPPI
UCHL1 WDR82 25348397 N/A physical interaction ComPPI
UCHL1 DDB1 25348397 N/A physical interaction ComPPI
UCHL1 RPTOR 25348397 N/A physical interaction ComPPI
UCHL1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 CDK1 25348397 N/A physical interaction ComPPI
UCHL1 CDK4 25348397 N/A physical interaction ComPPI
UCHL1 CDK5 25348397 N/A physical interaction ComPPI
UCHL1 PMAIP1 25348397 N/A physical interaction ComPPI
UCHL1 NMRAL1 25348397 N/A physical interaction ComPPI
UCHL1 ERN1 25348397 N/A physical interaction ComPPI
UCHL1 PRKN 25348397 N/A physical interaction ComPPI
UCHL1 CUL7 25348397 N/A physical interaction ComPPI
UCHL1 APP 16049941 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UCHL1 DERL1 25348397 N/A physical interaction ComPPI
UCHL1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UCHL1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UCHL1 AKT2 25348397 N/A physical interaction ComPPI
UCHL1 TERF2 25348397 N/A physical interaction ComPPI
UCHL1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UCHL1 ATG5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UCHL1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UCHL1 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
UCHL1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
UCHL1 PPTC7 24234451 25348397 28330616 association pull down ComPPI,IntAct
UCHL1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
UCHL1 UBC 12913066 16169070 16371654 20439756 20622874 22284438 23801757 2532544 27898060 9521656 stimulant N/A OmniPath

Visualization










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